Younis, A., Amer, M., Faisal, M. (2018). Vaginal Misoprostol for Cervical Priming Before Outpatient Hysteroscopy: A Randomized Controlled Trial. The Egyptian Journal of Hospital Medicine, 72(6), 4586-4592. doi: 10.21608/ejhm.2018.9785
Anis Mansour Nagib Younis; Mohamed Ibrahim Amer; Malames Faisal. "Vaginal Misoprostol for Cervical Priming Before Outpatient Hysteroscopy: A Randomized Controlled Trial". The Egyptian Journal of Hospital Medicine, 72, 6, 2018, 4586-4592. doi: 10.21608/ejhm.2018.9785
Younis, A., Amer, M., Faisal, M. (2018). 'Vaginal Misoprostol for Cervical Priming Before Outpatient Hysteroscopy: A Randomized Controlled Trial', The Egyptian Journal of Hospital Medicine, 72(6), pp. 4586-4592. doi: 10.21608/ejhm.2018.9785
Younis, A., Amer, M., Faisal, M. Vaginal Misoprostol for Cervical Priming Before Outpatient Hysteroscopy: A Randomized Controlled Trial. The Egyptian Journal of Hospital Medicine, 2018; 72(6): 4586-4592. doi: 10.21608/ejhm.2018.9785
Vaginal Misoprostol for Cervical Priming Before Outpatient Hysteroscopy: A Randomized Controlled Trial
Department of Obstetrics and Gynecology, Faculty of Medicine, Ain shams University, Cairo, Egypt
Abstract
Background: Misoprostol has generally shown good efficacy in promoting cervical softness and facilitating hysteroscopic procedures. Objective: To evaluate the efficacy and safety of vaginal misoprostol for cervical priming before diagnostic outpatient hysteroscopy (OH) without anesthesia. Patients and Methods: Design: Double-blind randomized controlled trial. Setting: University teaching hospital. Patient(s): Ninety patients requiring diagnostic OH for investigation of infertility or abnormal uterine bleeding in the reproductive age. Intervention(s): Patients were randomly allocated into two equal groups (n= 45). In group I, 200 mcg misoprostol was inserted into the posterior vaginal fornix 3 hours before OH; in group II (control), 250 mg metronidazole as placebo was inserted into the posterior vaginal fornix by investigator. A rigid 30 4-mm hysteroscope was used in the vaginoscopic technique. Main Outcome Measure(s): Ease of cervical entry (Likert scale), procedural time, patient acceptability (Likert scale), and pain scoring (visual analog scale). Result(s): Vaginal misoprostol significantly facilitated the procedure; cervical entry was easier, procedural time was shorter, patient acceptability was higher, and pain scoring was lower in group I compared with group II. Side effects of misoprostol were infrequent, minor, and transient. No complications were reported. Conclusion(s): The regimen of 200 mcg vaginal misoprostol administered 3 hours before diagnostic OH is a simple, effective, and safe method of cervical priming to facilitate the procedure without anesthesia.