El-Komey, F., EL-Gaafarawi, I., Moustafa, H. (2005). Toxic Effects Of Some Antispastic Drugs on the EEG: Some Biochemical And Immunological Studies on Rats.. The Egyptian Journal of Hospital Medicine, 20(1), 196-215. doi: 10.21608/ejhm.2005.18104
Fathy El-Komey; Inass EL-Gaafarawi; Hanan Moustafa. "Toxic Effects Of Some Antispastic Drugs on the EEG: Some Biochemical And Immunological Studies on Rats.". The Egyptian Journal of Hospital Medicine, 20, 1, 2005, 196-215. doi: 10.21608/ejhm.2005.18104
El-Komey, F., EL-Gaafarawi, I., Moustafa, H. (2005). 'Toxic Effects Of Some Antispastic Drugs on the EEG: Some Biochemical And Immunological Studies on Rats.', The Egyptian Journal of Hospital Medicine, 20(1), pp. 196-215. doi: 10.21608/ejhm.2005.18104
El-Komey, F., EL-Gaafarawi, I., Moustafa, H. Toxic Effects Of Some Antispastic Drugs on the EEG: Some Biochemical And Immunological Studies on Rats.. The Egyptian Journal of Hospital Medicine, 2005; 20(1): 196-215. doi: 10.21608/ejhm.2005.18104
Toxic Effects Of Some Antispastic Drugs on the EEG: Some Biochemical And Immunological Studies on Rats.
The National Center for Social and Criminological Research, Zamalek, P.O., P.C.11561, Cairo, Egypt.
Abstract
The toxicity of tizanidine and baclofen was studied on male rats. The oral clinical dose of tizanidine and baclofen( 0.216 and o.54 mg/ 100g body weight / day, respectively)was given for one, two, three and four weeks. Chronic administration of the two drugs causes damage to the lung and a significant reduction in serum and lung levels of GSH , Vit E , Vit C and SOD activity . Four weeks treatment induced significant elevation of GPX activity and MDA levels. The two drugs, also, caused inhibitory activity on proliferation of splenocyte triggered by Con A, LPS and IL-2 production cell activities. They also produced several abnormal patterns in the EEG including increased epileptiform discharges and synchronous rhythmic activity . Diffuse slowing , with increased beta and delta activity and decreased alpha activity , with
superimposed beta activity were recorded. than baclofen .