alakilli, S. (2007). Genotoxicity of paracetamol on the germ cells of Drosophilla melanogaster. The Egyptian Journal of Hospital Medicine, 29(1), 486-491. doi: 10.21608/ejhm.2007.17695
Saleha Y. M. alakilli. "Genotoxicity of paracetamol on the germ cells of Drosophilla melanogaster". The Egyptian Journal of Hospital Medicine, 29, 1, 2007, 486-491. doi: 10.21608/ejhm.2007.17695
alakilli, S. (2007). 'Genotoxicity of paracetamol on the germ cells of Drosophilla melanogaster', The Egyptian Journal of Hospital Medicine, 29(1), pp. 486-491. doi: 10.21608/ejhm.2007.17695
alakilli, S. Genotoxicity of paracetamol on the germ cells of Drosophilla melanogaster. The Egyptian Journal of Hospital Medicine, 2007; 29(1): 486-491. doi: 10.21608/ejhm.2007.17695
Genotoxicity of paracetamol on the germ cells of Drosophilla melanogaster
Department of Biology, Faculty of science, King Abdelaziz University, Saudi Arabia
Abstract
Paracetamol is a common analgesic and antipyretic drug. The aim of the present study is to determine the potential genetic effects of Paracetamol in Drosophilla melanogaster using two methods: Sex Linked Recessive Lethals (SLRL) test and effect of Paracetamol on enzyme activity using spectrophotometric analysis. Three concentrations of drug were used (5, 10, and 20 mM). The results reveal significant differences in S.L.R.L, except spermatozoa stages showed insignificant increases when the data of the four broods were considered all together in three treatments. Meanwhile, Paracetamol showed a genotoxic effects in the three categories of the two generations of S.L.R.L, F1 heterozygous females, F2 bar eye females and F2 wild type males on the genetic back ground of Cholinesterase in all treatments.