2024-03-29T14:10:00Z
https://ejhm.journals.ekb.eg/?_action=export&rf=summon&issue=3685
The Egyptian Journal of Hospital Medicine
1687-2002
1687-2002
2009
37
1
Physiological and Histopathological Effects of Tributyletin (TBT) on Lymnaea natalensis and Physa acuta.
El-feky
F
Raafat H
A
Kamal
H
Background: Two hermaphrodite snails Lymnaea natalensis and Physa acuta , the most abaundant gastropods in Nile River was investigated to determine the effect of Tributyletin oxide (TBT) on some physiological parameters and histopathological changes in the ovotestis of both snails. Methods: Nine plastic gars (six treated and three control sets) were used for each species of snails. Every aquaria contained 2 l. of dechlorenated water with concentration of 2 ppm of TBT. Samples of heamolymph and ovotestis tissues were taken after 2 and 4 weeks. Results: The physiological data revealed that the concentration of glucose, cholesterol, calcium, total proteins, albumin, and globulin changed from one species to the other in different responses and according to time of exposure. The histological data of the hermaphrodite gland or the ovotestis of both snails showed disturbances in differentiation and maturation process, cellular degeneration was also observed. Conclusion: Due to the hazardous effects of TBT on the physiology and the histology of the ovotestis of both snail species, more research on the impact of TBT or related compounds has to be conducted. The use of TBT as antifouling agent has to be restricted in the developing countries and replace it by related compounds with less or no side effects.
2009
10
01
610
620
https://ejhm.journals.ekb.eg/article_17472_5062a8142dcb9bb83243c82b92ab85de.pdf
The Egyptian Journal of Hospital Medicine
1687-2002
1687-2002
2009
37
1
Comparative Study of Three Sedative Techniques During Shock Wave Lithotripsy.
Wafaa G.
Ahmed
Background: Many authors found that dexmedetomidine is an effective, safe drug for sedation during extracorporeal shock wave lithotripsy (ESWL). Dexmedetomidine is a lipophilic α2- agonist ,which sedates patients by reducing sympathetic activity and the level of arousal ,thus patients lie calmly in beds but are easily roused to full consciousness. In the present study, the sedative, haemodynamics, and respiratory effects, and recovery time of dexmedetomidine and dexmedetomidine/fentanyl combination were compared to one of the commonly used sedative analgesic regimen (midazolam/fentanyl) in patients undergoing lithotripsy.
Methods: Sixty ASA I - II patients undergoing (ESWL) were divided into three equal groups and were randomized to receive either dexmedetomidine (dex group), dexmedetomidine fentanyl combination (dex/fentanyl group) or midazolam fentanyl (midazolam/fentanyl group) . In dex group: Initial loading dose of dex 1 μg/kg was infused for 10 min followed by continuous infusion 0.1-0.7 μg/kg/h. In dex/fentanyl group, initial dose of 1 μg/kg dex was infused over 10 min followed by continuous infusion 0.1-0.7 μg/kg/h. At the same time, fentanyl infusion started 1 μg/kg over 10 min. In midazolam/fenatnyl group, midazolam 0.05 mg/kg and fentanyl 1 μg/kg were infused over 10 min followed by continuous infusion of normal saline. Heart rate (HR), mean arterial pressure (MAP), oxygen saturation (SpO2), and respiratory rate were recorded. Pain intensity was evaluated with a visual analog scale. Depth of sedation was monitored using Ramsay sedation score (RSS). Recovery time, rescue analgesic and sedative were recorded.
Results: In all groups, no significant changes in oxygen saturation and respiratory rate were observed. In dex and dex/fentanyl groups there was a significant decrease in heart rate and mean arterial pressure during and post procedure. Supplemental fentanyl was required in 80% of patients in dex group to achieve a satisfactory level of analgesia (vs. 25% of patients in dex/fentanyl group and 40% of patients in midazolam/fentanyl group). Also 70% of patients in dex group received rescue midazolam vs. 15% in dex/fentanyl group and 20% in midazolam/fentanyl group. Time to home readiness was longer in dex,and dex/fentanyl groups than in midazolam/fentanyl group(80, 75, and 44 min), respectively.
Conclusion: Dexmedetomidine alone does not appear to be suitable for sedation in patients undergoing ESWL. Combination of dexmedetomidine with fentanyl can be used safely and effectively for sedation and analgesia during ESWL, so it could be an alternative to conventional midazolam/fentanyl regimen but it is associated with longer recovery time.
Sedation
Lithotripsy – Dexmedetomidine – Fentanyl – Midazolam
2009
10
01
621
629
https://ejhm.journals.ekb.eg/article_17473_120e4adc65c964c59e2d26f432d961d3.pdf
The Egyptian Journal of Hospital Medicine
1687-2002
1687-2002
2009
37
1
Effect of Coconut Oil Administration on Some Hemostatic Changes Associated with Obesity in Rats
Fatma Ahmed
Mohamed
Nehal Mohammad
Bahgat
Gehane M.
Hamed
Rania S.A.
Eisa
In the last few decades, coconut oil was claimed to have some beneficial health effects, attributed mainly to its medium chain triglycerides. It was, thus, intriguing to investigate the potential benefit of coconut oil in alleviating the prothrombotic tendency often encountered in obese individuals. The present study was carried out on 44 rats, of both sexes, aged 10 days at the start of the study. 31 out of 44 rats were offered high caloric diet (the cafeteria diet) for induction of obesity. Rats were allocated into the following groups: Group1: Control rats (C) (n=13 rats), comprising rats fed on the standard chow diet all-over the study period (24 weeks). Group2: Cafeteria diet-fed rats (Caf) (n=16 rats), comprising rats fed on cafeteria diet until the end of the study period and Group3: Cafeteria diet/coconut oil-fed rats (Caf/Coco) (n=15 rats), comprising rats fed on cafeteria diet with coconut oil starting from the 16th week till the end of the study period. At the end of the study, the BMI was assessed in the 3 studied groups and blood samples were collected for determination of platelet count and aggregation, prothrombin time (PT), activated partial thromboplastin time (APTT), fibrin degradation products (FDPs), and plasma lipid profile. The encountered results revealed that the mean BMI of the cafeteria diet-fed rats was significantly higher than the BMI of control rats, and that the mean BMI of rats receiving cafeteria/coconut oil diet for 9 weeks was significantly decreased compared to their matched caf group. The PT, APTT and platelet count were all non significantly different in the three studied groups. Platelet aggregation, on the other hand, was significantly increased in the caf group compared to the control group, and significantly decreased in the caf/coco group compared to both the caf group and the control group. The plasma FDPs levels were not significantly different in the 3 studied groups. The lipid profile was insignificantly different in the 3 studied groups except in the caf/coco group which revealed a significant elevation of total cholesterol and HDL- c compared to caf group. The present findings, thus, point to the possible beneficial effect of coconut oil feeding on obesity - induced enhanced platelet aggregation.
2009
10
01
630
643
https://ejhm.journals.ekb.eg/article_17474_cbee587f51ee6533eb5cd717d7b2581b.pdf
The Egyptian Journal of Hospital Medicine
1687-2002
1687-2002
2009
37
1
valuation of Diet Quality of Egyptian Children and Adolescents using Healthy Eating Index
Mervat A.
Esmail
Wafaa M.A.
Saleh
Nebal A.R.
Aboul Ella
Asmaa M.
Abd Allah
Background: Healthful eating is essential for development and well-being. Some dietary patterns are associated with 4 of the 10 leading causes of death (coronary heart disease, certain types of cancer, stroke, and type 2 diabetes). Major improvements in the health of the public can, therefore, be made by improving people’s dietary patterns. The U.S. department of Agriculture has developed an index, called the Healthy Eating Index (HEI) that was updated in the year 2002. It is based on different aspects of a healthful diet; the Index is designed to provide a measure of overall dietary quality, and the compliance with specific Dietary Guidelines recommendations. The aim of our study is to use the healthy eating index to assess the diet quality of a representative sample of the Egyptian children and adolescents and to examine the association between body mass index and caloric intake of the studied sample.
Materials & Methods: This study is a part of National Egyptian survey, Diet, Nutrition and Prevention of Chronic Non-communicable Diseases. The Healthy Eating Index was applied with slight modifications to measure how well the studied Egyptian students' diet conforms to recommended healthy eating pattern. The data were based on representative sample (2145) of children and adolescents (10 -18) years in 7 governorates from. One day of dietary intake data (24 hours recall) was collected, during an in-person interview. The Healthy Eating Index measures how well the studied children and adolescents' diets conform to the American Dietary Guidelines recommendations and the Food Guide Pyramid applied in our country. Ten dietary components have been identified and the overall Index has a total possible score ranging from zero to 100.
Results: Our results showed that the average Healthy Eating Index score was 59.1 out of a possible 100 and it ranged from 20 to 86, Only 0.5 percent of the students had Healthy Eating scores above 80; while 16.9 percent of them received scores below 50 and the majority (82.5 percent) had scores on the Healthy Eating Index between 51 and 80. In an effort to provide a "rating" of the overall student's diet, a grading scale was developed, the majority of students had diets rated as "Needs Improvement", only 0.5 % received diets rated as "Good" and 16.9 % had diets rated as "Poor". Males achieved a slightly higher average Index than females (59.7 Vs 58.2). The average score for food groups is much lower than that for dietary guidelines (23.5 Vs 35.6) out of total score of 50 for each. There was a significant positive correlation of BMI with caloric intake for male adolescents while, for females the correlation was insignificant and negative. More than 80 percent of the sample achieved the recommendations of the American Dietary Guidelines for total fat and cholesterol. Less than two-thirds of the students met the recommendations for saturated fat, Almost 30 percent of the students had the maximum score for sodium. Only 1.0 percent of them received a score of 10 for fibers.
Conclusion: the majority of Egyptian children and adolescent’ eating patterns, as measured by the HEI, need improvement. The results of the Index are useful in targeting nutrition education and health promotion activities, as it is a single summary measure of diet quality that can be used to monitor changes in food consumption patterns over time. A Food Quality System based on nutrient density can be one tool that can facilitate more healthful food purchases and dietary patterns.
Evaluation – Diet – Healthy – Index – Adolescents
2009
10
01
644
655
https://ejhm.journals.ekb.eg/article_17475_accf24b61f3921672503c68bb5f04afd.pdf
The Egyptian Journal of Hospital Medicine
1687-2002
1687-2002
2009
37
1
Histological Effects of Cystic Echinococcosis on the Liver of Sheep
Nabeel Zaki
Zahed
Aim of the work: The author investigated the histological effects of hydatid cyst (echinococcosis) on the liver of sheep. Material and methods: This study was based on liver specimens of slaughtered sheep (twelve of infected and four of uninfected). Specimens were collected from abattoirs at Central Slaughterhouse area KSA. These specimens were investigated for the presence of hydatid cyst and then examined histologically for identification of the histopathological changes.
Results: The infection with cystic echinococcosis induced significant elevation (P<0.05) in the hepatosomatic index of infected sheep. Hydatid cysts in the liver of sheep resulted in different histological lesions represented in inflammatory reaction, fibrosis and necrosis in the area near to the cysts. Meanwhile the hepatocytes exhibited vacuolated cytoplasm and dilated blood
vessels and disintegration in the epithelia of the bile Key words: Sheep, Liver, Hydatid cyst, Histology.
sheep
Liver
Hydatid cyst
histology
2009
10
01
656
663
https://ejhm.journals.ekb.eg/article_17476_8e05a94c5b019c4f820c167e38f87659.pdf
The Egyptian Journal of Hospital Medicine
1687-2002
1687-2002
2009
37
1
Localization and Sorting of Mast Cells in Human Ovary; A Histological and Immunohistochemical Study
Sahar M
Gamal
Nadia M
Al- Rouby
Mohammad A
Ali
Background: In human, mast cells (MCs) are classified according to their proteases’ content into tryptase-containing mast cells (MCT) and tryptase and chymase-containing mast cells (MCTC). In addition to phenotypic differences in MC subtypes, there is also functional distributional heterogeneity. The present study was carried out to determine the physiological distribution of mast cells in the different components of human ovary of different age groups. Mast cell sorting according to their proteases content was also attempted with special emphasis on the possible mechanism of their effects on ovarian functions. Material and methods: Archival blocks of human ovarian tissue from females with age ranging from 16 to 75 years were used. The specimens were divided into reproductive- and postmenopausal-age groups. Histological study using haematoxylin and eosin as well as Masson trichrome staining was performed. Immunostaining using monoclonal antibodies against tryptase and chymase was also carried out. Morphometric measurements in the form of mast cell count per high power field as well as optical density of positively immuno-stained mast cells in addition to measurement of area and area per cent were done. Obtained data were statistically analyzed for significance using student's T- test. Results: MCs were mainly found in the deep cortical stroma and in the vicinity of blood vessels. Occasionally, few cells were found in the corpora lutea. There were no immunostained MCs in the walls of the different ovarian follicles, corpora albicans or in the periphery of the ovarian cortical stroma. Statistical analysis revealed that the number of MCT was significantly higher than MCTC in the reproductive-age group in comparison to the postmenopausal-age group. The postmenopausal-age group demonstrated the presence of statistically significant more degranulated MCTC and high collagen content in comparison to the reproductive-age group. Conclusion: MC subtypes follow specific distribution pattern within the ovarian tissue in the different age groups which has an impact on different ovarian functions in many physiological and pathological situations.
mast cells
Age
tryptase
chymase
immunohistochemistry and ovary
2009
10
01
664
684
https://ejhm.journals.ekb.eg/article_17477_aa39bebf59fd9fc0e8b3522ca2d577a4.pdf
The Egyptian Journal of Hospital Medicine
1687-2002
1687-2002
2009
37
1
Do Microwaves of Mobile Phone Affect the Testicular Tissue Structure? (A histopathological and ultrastructural study)
Samir A.
Nassar
Background: Some studies have reported that microwave radiation have adverse effects on reproduction. Therefore, the purpose of this study was to investigate the possible effects of mobile phone microwaves on the histological structure and ultrastructure of mice testis. Material: five adult male mice were subjected to the mobile phone microwaves (900- 1800 MHz) for 30 days, one hour / day. Their exposure resulted in many histopathological and ultrastructural changes. Results: The light microscopic examination of testis of irradiated animals revealed: disorganization of the germinal epithelia, the seminiferous tubules taking elliptical aspects with intratubular vacuolization, abnormal morphology of early and late spermatids, rupture of the boundary membrane of the seminiferous tubules, pyknotic germ cells, damaged and ill- defined interstitial cells. The semithin sections demonstrated an increased incidence of Sertoli cells but they are detached from the basal membrane, the pachytene spermatocytes appeared with abnormal faint heterochromatin and abnormal shapes of rounded and elongated spermatids and spermatozoa. The ultrastructural examination illustrated Sertoli cells with lobulated nuclei, ill-defined nucleoli and ruptured cell boundary. Pachytene spermatocytes appeared with low integrity and faint and dispersed chromatin material. Some of them were necrotic and others were apoptotic. Early (rounded) and late (elongated) spermatids appeared with vacuolated cytoplasm and deformed morphology. The interstitial cells of Leydig appeared smaller in size with more electron dense components, vacuolated cytoplasm, ruptured mitochondria and fragmented nuclei. Their neighbouring blood capillaries appeared congested with damaged lateral pericytes . Conclusion: The results of this study showed that 1h / day (30 consecutive days) exposure of 900-1800 MHz microwaves affected the histological structure of mice testis particularly the Leydig cells and recorded an apoptosis-inducing effect on the spermatogenic cells. Further investigations are required to confirm these findings and to clarify the mechanism of action of the applied microwave exposure on male reproductive organs, as well as to establish the biological significance of these observations.
2009
10
01
685
699
https://ejhm.journals.ekb.eg/article_17479_f915b30eabb4331d7d4edd275afb3375.pdf
The Egyptian Journal of Hospital Medicine
1687-2002
1687-2002
2009
37
1
Allelic Polymorphism in the Endothelial Nitric Oxide Synthase Gene in Coronary Artery Diseases
Omnia H.
Seoudi
Effat M.
Abo El-kheir
Nareman M.
Younees
Olfat G
Shaker
Hala M.
El-mogy
Nitric oxide (NO) has an important role in the relaxation of the vascular smooth muscles, inhibits adhesion of platelets and leucocytes to the endothelium, reduces vascular smooth muscle cells
migration and proliferation and limits the oxidation of atherogenic LDL. Nitric oxide is constitutively produced in the endothelium of blood vessels from L- arginine by
the enzyme endothelial nitric oxide synthase (eNOS). Polymorphism in the (eNOS) gene is an important risk factor in the pathophysiology of coronary
artery disease( CAD) . In this study the polymorphism in (eNOS) gene was investigated in 30 patients with CAD and 20
control subjects using polymerase chain reaction (PCR) analysis. Patients were classified into 10 patients with unstable angina and 20 patients with myocardial infarction
Results : The distribution of (eNOS) genotypes in patients affected by unstable angina was 50% for GG genotype , 40% for GT genotype and 10% for TT genotype and in patients affected by myocardial infarction was (45%) for GG genotype, (35%) for GT genotype and (20%) for TT genotype.
In control subjects it was (50%) for GG genotype, (45%) for GT genotype and (5%) for TT genotype. Conclusion: there is a great controversy about the role of (eNOS) gene polymorphism in the pathophysiology of CAD.
2009
10
01
700
708
https://ejhm.journals.ekb.eg/article_17481_1a5cc453860aab746fb5bbff726d4e2d.pdf
The Egyptian Journal of Hospital Medicine
1687-2002
1687-2002
2009
37
1
Studies on the effect of antioxidant Selenium-ACE after treatment with Praziquantel and Mirazid in Schistosoma mansoni infected mice
Muhammad Hamdy
Emam
Mona
Abd El-Rahman
Irene Sameh
Gamil
Marwa Ahmed
Muselhy
Background: This study deals with the evaluation of parasitological, histopathological and biochemical effect of Praziquantel (PZQ) and Mirazid (MZ) with or without Selenium-ACE (Se-ACE) on male albino mice infected with S.mansoni and trying to evaluate the antioxidant effect of Se-ACE and its role in reducing the severity of the infection.
Results: The obtained results indicated that treatment with PZQ produced more reduction in worm burden and ova count/gm liver than MZ compared to the infected control group. PZQ showed the highest reduction in liver granuloma number and diameter when compared to MZ group while both drugs showed a significant effect in restoration of the liver transaminases and protein fractions towards their normal levels indicating the safety of both drugs as anti S. mansoni chemotherapeutics, Se-ACE showed a high efficacy as a co-treatment, potentiating the effect of PZQ and MZ in reducing the worm burden, ova count/gm liver, number and diameter of liver granuloma and restoration of liver transaminases and protein fractions to their normal levels during treatment of S. mansoni infection.
Conclusion: the rank order of potency in protection against liver cell damage was PZQ 500 mg/kg > MZ 600 mg/kg where Se-ACE showed a couraging criterion as a co- treatment potentiating the effect of the antischistosomal medications through its anti- oxidant activity.
praziquantel
Mirazid
Selenium –ACE
S. mansoni and co-treatment
2009
10
01
709
725
https://ejhm.journals.ekb.eg/article_17482_7046727e002f7d3fba757af49ba0ccd7.pdf
The Egyptian Journal of Hospital Medicine
1687-2002
1687-2002
2009
37
1
A Study to Assess The Efficacy of Balloon Angioplasty of The femoropopliteal Arteries in The Relief of Critical Limb Ischemia (CLI)
Ehab M.
Abdo
Hatem A.
Mgahid
Abdel Aziz
Abo Elella
Purpose: The aim of the study was to evaluate the results of percutaneous transluminal angioplasty
(PTA) of femoropopliteal arteries in patients with critical lower limb ischemia;
Materials and methods: From June 2006 till May 2008, 40 patients underwent 40 PTA procedures, 18 were of the superficial femoral artery (SFA), 7 of the popliteal artery, 9 of both arteries and 6 of the common femoral artery (CFA). Twenty-nine procedures were performed for treatment of stenoses and 11 for occlusion. The patients were monitored clinically with non-invasive hemodynamic studies.
Results: The technical success rate was 97.5%. Overall primary patency rates at 24 months were 67.5%. Primary patency rates in limbs with occlusion were 45.5% compared with 75.9 in limbs with stenoses. Two major amputations were performed. The overall survival rate was 95%.
Conclusion: The 2 years results of femoropopliteal PTA performed for treatment of CLI seemed to be near the results of infrainguinal bypass grafting reported in literature. Because PTA does not preclude the performance of future surgery and associated with low morbidity and mortality rates, it should be a first choice treatment for patients with CLI for selected lesions.
2009
10
01
726
732
https://ejhm.journals.ekb.eg/article_17483_0ca855a0e8bafe07dd75f9c009010d2d.pdf
The Egyptian Journal of Hospital Medicine
1687-2002
1687-2002
2009
37
1
EFFECT OF CYNARA SCOLYMUS L. (ARTICHOKE) EXTRACT ON LIPID PROFILE OF HYPERLIPIDEMIC MALE RATS
Ghada, Z A
Soliman
Tamer M M
Saad
Introduction: Cynara scolymus L. (Artichoke) grows in Egypt and other countries. It is used as foods and has medicinal properties. Artichoke extracts have been shown to produce various pharmacological effects, such as the inhibition of cholesterol biosynthesis and low density lipoprotein (LDL) oxidation.
Purpose: To study the effect of Cynara scolymus L. and its extract on lipid profile of hyperlipidemic male rats.
Study Design: Eighty male albino rats, Sprague-Dawley strain, weighing (204.0±10) were housed individually in wire-mesh cages. Induction of hyperlipidemia was carried out on all rats except negative control group by addition of cholesterol to the basal diet (2%) +0.25 bile salts (taurocholic) for 4 weeks. After that the rats were divided into 8 groups (10 rats each), the first (1st) and 2nd groups was negative (normal) and positive control groups (hyperlipidemic), groups from G 3: G8, they were fed on basal diet supplemented with 2 level of extract (4 & 8 %) of either heads, heads, or leaves extract. At the end of the experimental period (6 weeks treatment) rats were fasted over night before sacrificing, blood was collected, centrifuged; serum or plasma was stored at - 20 0C until analysis. Lipid profile and triacylglycerol were measured.
Results and Discussion: Artichoke extracts (plant, head, and leaves) significantly reduced cholesterol, low density lipoprotein cholesterol (LDL-C), very low density lipoprotein cholesterol (VLDL-C) and triacylglycerol. No change was observed with high density lipoprotein cholesterol (HDL-C). Heads extract being more powerful. This effect may be due to its content of mono- and di-caffeoylquinic acids, flavonoids and other contents or through inhibition of LDL oxidation.
Conclusion: artichoke extract seems to be positively modulate hypercholesterolemia and can provide a protection from cardiovascular diseases.
Cynara scolymus L. (artichoke)
2009
10
01
733
741
https://ejhm.journals.ekb.eg/article_17485_6e363e1991ddedbb6a64a69ef4e0ab9b.pdf
The Egyptian Journal of Hospital Medicine
1687-2002
1687-2002
2009
37
1
Anatomical and Histochemical Studies of the thyroid gland of two Egyptian reptiles
Boshra A.
El-Salkh
Zaki T.
Zaki
Ibrahem G.
Ibrahem
Samia
Saad
Two species of lizards are used in the present work Eumeces schneiderii as a hibernating reptile and Laudakia stellio brachydactyla as a non-hibernating one.
Macroscopically, the thyroid of Eumeces schneiderii is formed of separate paired structures lying on both sides of the bifurcation of left and right carotid arteries. The thyroid of Laudakia, is formed of two well defined lobes each lying on either side of the trachea with a narrow connecting isthmus.
Microscopically, the thyroid gland in both animals is composed of a big number of follicles which are held together by a loose connective tissue. The Interfollicular spaces are filled with blood sinusoids. Each follicle is composed of one layer of epithelial cells, which vary in their heights from winter to summer.
In Laudakia, the gland never become completely inactive during winter. In Eumeces schneiderii , it is completely inactive during hibernation.
Intracellular colloid droplets are rarely found in the thyroid of Laudakia, while they are very frequent In Eumeces schneiderii. This colloid shows regular seasonal changes in both animals depending on the degree of activity of acini.
2009
10
01
742
758
https://ejhm.journals.ekb.eg/article_17487_c397c039f2195d40dcdf40edfd7a2c98.pdf
The Egyptian Journal of Hospital Medicine
1687-2002
1687-2002
2009
37
1
Effects of the methanolic extracts of Zizyphus spina christi, Olea europaea and Morus alba leaves in Streptozotocin- induced diabetic rats.
A. I.
Othman
M. A.
Amer
R. F.
Samaha
M.
Abdel-Mogib
Background:The present study aims to investigate the hypoglycemic, hypolipidimic and antioxidant effect of the methanolic crude extracts of Zizyphus spina christi, Morus alba and Olea europaea leaves, individually or in combination against diabetes induced rats by Streptozotocin (STZ).
Results:Hyperglycemia and hyperlipidaemia except in high density lipoproteins (HDL) were observed in serum after 5 weeks of STZ administration. This was associated with a depression in hepatic glutathione (GSH) concentration as well as hepatic catalase (CAT), glutathione-s- transferase (GST) and superoxide dismutase (SOD) activates. In addition hepatic thiobarbituric acid-reactive substance (TBARS) and protein carbonyl (PC) were significantly elevated, indicating increased lipid and protein oxidation and oxidative stress. Depression in blood hemoglobin (Hb) content, serum insulin levels, total antioxidant capacity (TAOC) and nitric oxide (NO) levels as well as body weight gain were also observed in diabetic rats. Administration of 100mg/kg alcoholic extracts of Zizyphus spina christi, Morus alba and Olea europaea leaves 3 days before and after STZ injection daily for 5 weeks significantly ameliorated the oxidative stress evidenced by lowering TBARS & PC as well as increasing hepatic GSH concentration and CAT, GST and SOD activates as compared with STZ treated rats. These effects were paralleled with marked protection against STZ induced hyperglycemia and disturbance of lipid profile. They also caused a great improvement in insulin levels, TAOC, NO, Hb content and body weight gain. Conclussion:Thus, these results showed that the administration of the crude extracts of either Zizyphus spina christi, Morus alba or Olea europaea leaves individually or in combination might improve the clinical manifestation of diabetes and decrease the oxidative stress, this study supports the beneficial effects of these extracts especially Zizyphus spina christi, which showed marked amelioration and this may be attributed to the presence of saponin glycosides which have an inhibitory effect of serum glucose level in addition to enhance the cellular antioxidant defense. This activity contributes to the protection against oxidative damage in STZ induced diabetes.
diabetes
Zizyphus spina-christi
Olea europaea
Morus alba, antioxidants
lipids
Oxidative stress markers
Nitric oxide
2009
10
01
759
771
https://ejhm.journals.ekb.eg/article_17488_e0ecbec53bbf5c2beab21fa7edb6b1b7.pdf
The Egyptian Journal of Hospital Medicine
1687-2002
1687-2002
2009
37
1
Quality of life in psoriasis patients
Fatma M
Abd Al Salam
Seham F
Mohamed
Taghreed M
El-Shafie.
Hesham M
Abuhegazy
Skin and psyche share embryonic origins, various psychological factors, including emotional trauma and stressful life events, may affect both onset and progression of some skin conditions, Psoriasis is a chronic skin disease with substantial impact on patient's social and relational ways of living and subsequently on their quality of life. This chronic condition has a significant negative impact on patients' quality of life. Psoriasis has been linked to patients depression and suicidal tendencies Patients and Methods The study group consisted of 50 consenting consecutive cases of psoriasis vulgaris, of both sexes, aged 18-62 years (41.44 ± 0.101), and with duration of the disease 6-10 years, attending the dermatology outpatient clinic of Al Zahraa university hospital. The extent of clinical severity of the disease was assessed by the psoriatic area and severity index (PASI Score), Assessment of quality of life of patients by Lehman Quality of Life Interview (LQLI) .According toPASI score they were devided into 3groups :mild cases were treated by topical steroid and salyslic acid while moderate cases were treated by NB-UVB and severe cases were treated by systemic methotrexate. Results showed that 57.4% of patients were unsatisfied with their family relations and 43.5% are satisfied. However, about their social relations they were 55.3% satisfied while 44.6% were unsatisfied. In the other hand, they were 52.3% satisfied with their finance while the other 48.2% were unsatisfied with it. As regard, work or school they were 66.4% satisfied and 33.5% unsatisfied. While they were 85.1% satisfied with low, safety, and 14.8% unsatisfied. The same for health 94.4% satisfied and 6.5% unsatisfied .The third group treated by systemic methotrexate show marked increase in LQLI. Conclusions: Psoriasis is a disease with profound impact on the psychological and social aspect of the patient, particularly because of its visibility. Systemic therapy of psoriasis could improve their quality of life. Thus assessment by a health professional of the extent of apparent disease in terms of the clinical severity alone may not suffice, and a more holistic approach to the quality of life is mandatory.
Psoriasis
quality of life
2009
10
01
772
779
https://ejhm.journals.ekb.eg/article_17489_adcddca8cd42a900bd1473651b4a7fc1.pdf