Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
57
1
2014
10
01
Cognitive Competency of Filipino Nurses Working in Some Hospitals of Taif City, Kingdom of Saudi Arabia
384
394
EN
Adnan Amin
Alsulaimani
Department of Pediatrics College of Medicine, Taif University, POBox 888 Taif 21974, Kingdom of Saudi Arabia
Daisy A.
Vicencio
Department of Quality Control, Al-Ameen Hospital, POBox 685 Taif 21944, Kingdom of Saudi Arabia
Fred B.
Ruiz
Graduate School, College of Nursing, Fatima University, Valenzuela, Philippines,
Hatim A.
Elsheikh
Department of Clinical Pharmacology, College of Medicine, Taif University, POBox 888 Taif 21974, Kingdom of Saudi Arabia
elsheikh59@yahoo.com
10.12816/0008472
<strong>Background:</strong>Nurses give care to diverse client population, which necessitates that, they should be culturally competent. Competence in cross cultural practice is a process requiring experience and continued interest in learning and in sharpening cultural assessment and communication skills.
<strong>Objectives:</strong> Toinvestigate the cognitive competency of Filipino nurses working in five hospitals at Taif City, Kingdom of Saudi Arabia. The study evaluates strength of self-efficacy perception ofthenurses, on the cognitive constructs and the difference among the strength of self-efficacy perception of the nurses when grouped according to their demographic profiles.
<strong>Methods:</strong>Transcultural Self-Efficacy Tool (TSET) Kit was used to measure the cognitive competency of three hundred and seven respondent Filipino nurses working in five hospitals of TaifCity.
<strong>Results:</strong>The strength of self -efficacy perceptions of the nurses within the cognitive constructs shows that the five highest means score dealt with “safety”, “hygiene", “Informed consent", “pain relief and comfort” and “life support and resuscitation” while the five lowest scores dealt with “Health History and Interview”, “Sexuality”, “Birth”, “Pregnancy” and "Diagnostic Test". The differences among the strength of self -efficacy perception of the nurses on the cognitive construct when grouped according to seven demographic profiles shows that only three of the demographics were different in some of the cognitive construct variables. These were work setting, department and preferred position
<strong>Implications:</strong>The findings of the present study suggest in-service educational training to all nurses on transcultural nursing to enhance their cultural competencies.In addition, Arabic Language training is recommended as one of the requirements for new nurse applicants.
<strong> </strong>
Cognitive competency,cognitive construct,Filipino,Nurses,transcultural self-efficacy
https://ejhm.journals.ekb.eg/article_15532.html
https://ejhm.journals.ekb.eg/article_15532_b6fbbc600e4f96480dbb8c7419a0fced.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
57
1
2014
10
01
Apoptosis, Cytogenetic and Endothelial Progenitor Cells in the Peripheral Blood of Industrial Radiographers
271
279
EN
Tawfik
M.S
Department of Health Radiation Research, National Center for Radiation Research and Technology – Atomic Energy Authority of Egypt
mstewfik@yahoo.com
Soheir
Korraa
Department of Health Radiation Research, National Center for Radiation Research and Technology – Atomic Energy Authority of Egypt
Mona
Yousri
Department of Clinical Pathology – Faculty of Medicine – Al Azhar University
<strong>Background:</strong> Radioactive sources and fixed or mobile X-ray equipment are used for both process and quality control in the metallurgical and fertilizer industries. Workers in the nuclear industry are a suitable sector of the populace for the direct estimation of radiation effects at low doses as they are typically monitored and restricted to effective doses of 100 mSv every 5 years. A dose-related increased mortality from circulatory diseases has been observed in some studies of nuclear industry workers, but it is unclear whether this reflects a real effect of radiation exposure or a spurious one. The aim of the present study was to detect the circulating endothelial progenitor cells (EPCs) in the peripheral blood and the frequency of micronuclei (FMN) among industrial radiographers occupationally exposed to ionizing radiation at the Steamer’s Welding Company and EL Nasr Company for the manufacture of Fertilizers and Chemicals in Suez and Talkha, Egypt.
<strong>Material and Methods:</strong> Venous blood samples were obtained from 30 industrial radiographers exposed to x-rays during industrial procedures <em>vs.</em> 20 persons not exposed to ionizing radiation as control subjects. Blood samples were assayed for total and differential blood counts and cell phenotype of circulating EPCs, whose surface markers were identified as CD34, CD133 and kinase domain receptor (KDR), frequency of chromosomal aberrations (FCA), apoptosis percentage in circulating lymphocytes together with plasma stromal cell derived factor-1α (SDF-1α) and vascular endothelial growth factor (VEGF).
<strong>Results</strong>: The results of this study revealed a significant increase in FCA with respect to total number of dicentrics (0.09 ± 0.03 <em>vs.</em> 0.0005 ± 0.0001) and rings (0.01 ± 0.0012 <em>vs.</em> 0) together with apoptosis percentage (7.3 ± 2.8 % <em>vs.</em> 2.4 ± 1.5 %) among industrial radiographers compared to control subjects respectively, indicating radiation exposure among such workers. Also a significant increase was observed in plasma SDF-1α (2750 ± 370 <em>vs.</em> 2270 ± 430pg/ml), VEGF (157.9 ± 16.9 <em>vs.</em> 137.5 ± 12.6 pg/ml) among industrial radiographers compared to control subjects. Percentage of circulating mononuclear cells expressing CD34 (53 ± 3.9 <em>vs.</em> 54.2 ± 10.6/ 10<sup>5</sup> mononuclear cells), CD133 (82.4 ± 4.8 <em>vs.</em> 54.2 ± 10.6/ 10<sup>5</sup> mononuclear cells) and KDR (48.7 ± 12.5 <em>vs. </em>43.5 ± 8.2/ 10<sup>5</sup> mononuclear cells) was significantly higher among industrial radiographers compared to control subjects.
<strong>Conclusion</strong>: It is concluded that the industrial radiographers have increased numbers of circulating EPCs and increased levels of SDF-1 and VEGF, which denotes an increased capacity for tissue repair.
<strong> </strong>
<strong> </strong>
Endothelial progenitor cells,apoptosis,stromal derived factor-1α,Industrial Radiographers,Ionizing radiation
https://ejhm.journals.ekb.eg/article_15535.html
https://ejhm.journals.ekb.eg/article_15535_74ce3693f7143bf8be1b811374879ea5.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
57
1
2014
10
01
Occult Hepatitis C Virus Infection in Haemodialysis Unit: A Single-center Experience
280
288
EN
Abdel Hamid A.
Serwah
Internal Medicine Department, College of Medicine, Taif University, KSA
Waleed S.
Mohamed
Internal Medicine Department, College of Medicine, Taif University, KSA
Mohamed
Serwah
Internal Medicine Department, College of Medicine, Taif University, KSA
Awateif
Edreis
Tropical medicine Department, College of Medicine, Taif University, KSA
Ahmad
El Zaydi
Consultant of Nephrology, KAASH, KSA
10.12816/0005575
<strong>Background & Aims: </strong>Detection of hepatitis C virus RNA in peripheral blood mononuclear cells (PBMC) and/or hepatocytes in the absence of HCV RNA in serum, designated as ‘occult HCV infection’, has been a matter of controversy in the recent years. Occult hepatitis C virus (HCV) infection has not been investigated in haemodialysis patients. We investigated for the first time the prevalence of occult HCV infection in large cohorts of chronic hemodialysis (CHD) patients in a single heamodialysis center at Al-Taif, KSA.
<strong>Methods: </strong>We enrolled 84 CHD patients, whose sera are negative for HCV markers. HCV RNA was tested in PBMC using a sensitive commercial real time assay. In this study, real-time PCR was used to test for the presence of genomic HCV-RNA in peripheral blood mononuclear cells of all of these patients. For comparison, 20 patients on HD with evidence of chronic hepatitis C virus infection were included as a control group.
<strong>Results: </strong>In CHD patients, occult HCV infection, determined by the presence of genomic HCV-RNA in peripheral blood mononuclear cells (PBMNCs), was found in 13.4 % of the patients; 83 % of these patients had ongoing HCV replication, indicated by the presence of HCV-RNA. Patients with occult HCV infection had spent a significantly longer time on heamodialysis and had significantly higher mean alanine aminotransferase levels during the 3 months before study entry. Compared to CHCV patients, those with occult HCV have less elevated bilirubin, AST and ALT.
<strong>Conclusions: </strong>The prevalence of occult HCV infection was moderate in our CHD patients, and it did not appear to be clinically relevant. Further studies in other geographic populations with high HCV endemicity are required to clarify the significance of occult HCV infection in these patient groups.
<strong>Abbreviations</strong>
HCV, Hepatitis C Virus ; antibody against HCV; PBMC, peripheral blood mononuclear cells; rRT-PCR, real time reverse transcriptase polymerase chain reaction; CHD, chronic hemodialysis.
Occult hepatitis C,HCV,PBMCs,Peripheral blood mononuclear cells,prevalence,Hemodialysis,HCV RNA,anti-HCV
https://ejhm.journals.ekb.eg/article_15536.html
https://ejhm.journals.ekb.eg/article_15536_34b21473de94f9537d2912fb0d192e1f.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
57
1
2014
10
01
Role of Percutaneous Microwave Ablation in Treatment of Hepatocellular Carcinoma
289
299
EN
Ahmed Tharwat
Sayed
Department of Radiodiagnosis, Faculty of Medicine, Ain Shams University
Sahar M
El Fiky
Department of Radiodiagnosis, Faculty of Medicine, Ain Shams University
Osama M
Hetta
Department of Radiodiagnosis, Faculty of Medicine, Ain Shams University
Osama A
Khallaf
Department of Radiodiagnosis, Faculty of Medicine, Ain Shams University
10.12816/0005576
<strong>Introduction:</strong> Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide with an annual occurrence of one million new cases. An etiologic association between HBV infection and the development of HCC has been established. Hepatitis C virus is also proving an important predisposing factor for this malignancy, the use of minimally invasive Percutaneous ablative technique (e.g. Radiofrequency (RF) and Microwave ablation (MW) has gained great momentum and because of the drawbacks of RF ablation, several groups have successfully proved the efficacious nature of Microwave ablation in the treatment of hepatocellular carcinoma.
<strong>Aim of the Work:</strong> The aim of this work is to highlight the role, the principles and the applications of percutaneous Microwave Ablation in Hepatocellular carcinoma.
<strong>Methods: </strong>The studied group included 30 patients (25 men and 5 women) with hepatocellular carcinoma. All patients underwent microwave ablation for the hepatocellular carcinoma.
<strong>Results: </strong>The results of the procedures will be assessed as regarding sizeand enhancement of the lesion (s) on triphasic CT abdomen before the procedure and at the follow up at one month as well as the Alpha fetoprotein levels.
<strong>Conclusion: </strong>MWA technique represents a safe, fast and efficacious way to perform hepatic ablation in patients with HCC. Initial results are encouraging; however, longer follow-up is needed for further classification of our results.
<strong> </strong>
https://ejhm.journals.ekb.eg/article_15538.html
https://ejhm.journals.ekb.eg/article_15538_fa37be5e79e57aa4d23d8bce6af09b6a.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
57
1
2014
10
01
The Potential Protective and Therapeutic Effects of Aloe Vera Juice Against Malathion Induced Haematological Changes in Rabbits
300
310
EN
Ahmed R.
Hassan
Biological and Geological Sciences Department - Faculty of Education – Ain Shams University
Mohamed S.
Al-Shinnawy
Biological and Geological Sciences Department - Faculty of Education – Ain Shams University
Dalia N.
Ismail
Biological and Geological Sciences Department - Faculty of Education – Ain Shams University
Mohamed A.
Shahin
Biological and Geological Sciences Department - Faculty of Education – Ain Shams University
10.12816/0005577
<strong>Background:</strong> the potential protective and therapeutic effects of Aloe vera juice against malathion induced haematological changes in young rabbits (<em>Oryctolagus cuniculus</em>) were evaluated in this study.
<strong>Material and methods</strong>: Rabbits were allocated into two sets of experiments short (7 days) and long (21 days) periods. Animals of each set were divided into eight groups; four treated groups and each treated group had its own control. The animals of the first group were orally dosed with Aloe vera juice (0.84 ml/kg b. wt.). Rabbits of the second group were orally dosed with malathion (5 mg/kg b. wt.). In the third group (the protective group) animals were dosed orally with malathion concomitant with Aloe vera juice. Animals of the fourth group (the therapeutic group) were dosed orally with malathion; for 7 days followed by Aloe vera juice for the same period. All the animals were sacrificed, blood samples were collected and used to determine the levels of hematological indices: red blood cells (RBCs), white blood cells (WBCs), haemoglobin (Hb), haematocrit (Hct), mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH) and mean corpuscular haemoglobin concentration (MCHC).
<strong>Results:</strong> rabbits treated with <strong>Aloe vera juice</strong> (<strong>group 1</strong>) showed insignificant change in WBCs count, MCH and MCHC after treatment for both periods. On the other hand, other parameters exhibited significant (RBCs count) and highly significant (Hb and Hct values) change in rabbits treated for the short period. The rabbits of the <strong>second group</strong> (treated with <strong>malathion)</strong> exhibited a marked increase in WBCs count, MCV and MCH values, while, the values of RBCs, Haemoglobin and Hct were decreased.
The <strong>protective group (Group3</strong>) showed that the values of all the tested haematological parameters (except MCHC, in both periods of treatment, and WBCs count in the short period of treatment) recorded a significant change in rabbits treated for short (7 days) or long (21 days) periods. A marked recovery in RBCs count and MCH value was observed in rabbits treated for 21 days. Regarding to <strong>group 4 (the therapeutic group</strong>), it was found that in both terms the rabbits exhibited insignificant changes in the values of all the tested haematological parameters compared to their corresponding controls, except three parameters in which they recorded significant (WBCs count, MCHC) and highly significant (Hct) increase compared to their control values after the long period only. These observations indicated the ability of Aloe vera juice to improve the deleterious effects caused by malathion administration.
<strong> </strong>
Haematology,Aloe vera juice,malathion,Rabbits
https://ejhm.journals.ekb.eg/article_15540.html
https://ejhm.journals.ekb.eg/article_15540_7bdf821daf379a54d0a7ebf676eeb7c7.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
57
1
2014
10
01
Diagnostic Accuracy of Multi-detector CT Angiography in Evaluation of Lower Limb Arterial Diseases: Comparative Study with Conventional Angiography
311
320
EN
Kareman M.
Ahmed
Radiology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Sahar N.
Mohamed
Radiology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Sherif H.
Abo Gamra
Radiology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Nivine A.
Chalabi
Radiology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
10.12816/0005578
<strong>Purpose: </strong>To assess the diagnostic accuracy of multi-detector CT angiography in the assessment of lower extremity arterial diseases by comparing the results with thestandard of reference, conventional angiography.
<strong>Patients and Methods</strong>: The studied group included 140 patients with suspected diagnosis of lower limb arterial disease on the basis of clinical examination or Doppler study with no age or sex predilection between March 2011 and November 2013. All patients were evaluated with lower limb angiography by multi-detector computed tomography and conventional angiography. The data obtained was statistically analysed to assess the accuracy of diagnosis of lower limb arterial diseases by MDCT angiography compared to conventional angiography that described in terms of count and percentage.
<strong>Results</strong>: MDCT angiography findings showed 90.3% overall agreement with CA findings regarding the degree of stenosis while regarding the stenosis length MDCT angiography results showed 87.5% overall agreement with CA results. The overall sensitivity of MDCT angiography was 94.5%, specificity was 92.2%, and accuracy was 95.3%.
<strong>Conclusion</strong>: Multi–detector row CT angiography can be used as an alternative to conventional angiography in the evaluation of aortoiliac and lower extremity arteries in patients with peripheral arterial disease.
<strong> </strong>
Computed tomography (CT),Conventional Angiography (CA),multi-detector computed tomography (MDCT)
https://ejhm.journals.ekb.eg/article_15541.html
https://ejhm.journals.ekb.eg/article_15541_23adbd37bc83bfe446e40599713c4d7d.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
57
1
2014
10
01
Study of Serum Monocyte Chemoattractant Protein-1AS A Marker in Rheumatoid Arthritis
321
332
EN
Wafaa Mohie El deen
Abdel Fatah
Department of medical biochemistry, faculty of medicine for girls Al-Azhar University
Laila Atef
Ahmed
Department of medical biochemistry, faculty of medicine for girls Al-Azhar University
Nareman Youniss
Mohamed
Department of medical biochemistry, faculty of medicine for girls Al-Azhar University
Mona Abd El-Raof
Abd El-Kader
Department of internal medicine faculty of medicine for girls Al-Azhar University
Fawkia Eissa
Zahran
Department of internal medicine faculty of medicine for girls Al-Azhar University
10.12816/0007759
<strong>Abstract:</strong> Rheumatoid arthritis (RA) is a chronic, multisystem autoimmune disease which manifests itself in multiple joints of the body. It is characterized by infiltration of inflammatory cells such as monocytes and it is believed to be the result of a faulty immune response.
Chemokines play a major role in selectively recruiting monocytes, neutrophils, and lymphocytes, as well as in inducing chemotaxis through the activation of G-protein-coupled receptors. Monocyte chemoattractant protein-1 (MCP-1/CCL2) is one of the key chemokines that regulates migration and infiltration of monocytes/macrophages.
<strong>Aim of The Work:</strong> was to study the role of serum Monocyte chemotactic protein-1 (MCP-1) in patients with rheumatoid arthritis as a diagnostic and prognostic marker and the possible association with disease activity.
<strong>Subjects and methods</strong>: Forty rheumatoid arthritis diseased patients were selected , they were 3 males and 37 females. The patients were categorized into two groups according to activity of the disease regarding DAS score . Another 20 healthy subjects, 2 males and 18 females, with no history of rheumatoid disease were recruited as controls .Results: this study showeda highly significant increase in MCP-1 and ESR in all rheumatoid arthritis patients groups , active rheumatoid arthritis patients group and inactive rheumatoid arthritis patients group compared to control group.
Correlation study of serum MCP-1 revealed a significant positive correlation between serum MCP-1 and ESR and DAS score in all patients versus the healthy group and a significant positive correlation between serum MCP-1 and ESR in the active group. ROC curve analysis was showing the diagnostic performance of serum MCP-1 in rheumatoid arthritis patients(active and inactive) versus the healthy control group, at a cut-off level of 52.5 ng/ml., the diagnostic sensitivity, specificity, negative predictive value and positive predictive value were 98%, 93%, 93% and 98% respectively
Also, it shows the diagnostic performance of serum MCP-1 in discriminating active rheumatoid arthritis patients from the inactive group, at a cut-off level of 61ng/ml <strong>Conclusion: </strong>- Serum MCP-1 is one of the best indicator of clinical arthritic activity in RA patients. It represents a novel, independent indicator of clinical arthritic activity that also provides a good reflection of effect of treatment in rheumatoid arthritis patients.
<strong> </strong>
<strong> </strong>
Rheumatoid arthritis (RA),serum Monocyte chemotactic protein-1 (MCP-1)
https://ejhm.journals.ekb.eg/article_15543.html
https://ejhm.journals.ekb.eg/article_15543_6c94624443a70b782d4757840c746a5f.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
57
1
2014
10
01
Non leaking Cystoid Macular Edema
444
449
EN
Mona Mohamad A.
Farag
Ophthalmology Department, Faculty of Medicine(For Girls), Al Azhar University, Cairo, Egypt
10.12816/0008479
The current study was conducted to report the discrepancy in findings between Spectral Domain-Optical Coherence Tomography (SD-OCT) & Fundus Fluorescein Angiography (FFA) examinations of the macular area regarding Cystoid Macular Edema (CME) in patients with diabetic retinopathy (DR) or retinal vein occlusion (RVO).
<strong>Patients &Methods;</strong>
This was a retrospective observational case study, involved 205 eyes of 179 patients. Eyes with diabetic retinopathy or retinal vein occlusion those underwent SD-OCT & FFAwere included in the study. All eyes had SD-OCT detected CME.
<strong>Results;</strong>
In the current study, SD-OCT detected CME was associated with diabetic retinopathy in 56.1% of eyes & with retinal vein occlusion in 43.9 % of eyes. CME associated with DR or RVO was undetected on FFA examination in 12.2% and 7.3 % of eyes, respectively.
<strong>Conclusion;</strong>
Both SD-OCT & FFA were complementary to each other in the detection of CME in eyes with DR or RVO. The use of both SD-OCT & FFA aided in the diagnosis, the choice of the treatment option &the final visual outcome.
<strong> </strong>
<strong> </strong>
Cystoid,edema
https://ejhm.journals.ekb.eg/article_15544.html
https://ejhm.journals.ekb.eg/article_15544_ed6899cce6763d2f3b5ba031099a2297.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
57
1
2014
10
01
Pegylated Interferon Alfa 2a and Small Dose Ribavirin in The Treatment of HCV Genotype 4 in End-stage Renal Disease
450
459
EN
Shendy Mohammed
Shendy
Hepatogastroenterology department Theodor Bilharz Research institute, Giza, Egypt.
Mahmoud
AlAnsary
Hepatogastroenterology department Theodor Bilharz Research institute, Giza, Egypt.
Abdel Aziz Ali
Saleem
Hepatogastroenterology department Theodor Bilharz Research institute, Giza, Egypt.
Mohamed Darwish
El-Talkawy
Hepatogastroenterology department Theodor Bilharz Research institute, Giza, Egypt.
Ayman
AbdelAziz
Hepatogastroenterology department Theodor Bilharz Research institute, Giza, Egypt.
Manar
Raafat
Nephrology department,Theodor Bilharz Research institute, Giza, Egypt.
Malak
Nabil
Nephrology department,Theodor Bilharz Research institute, Giza, Egypt.
10.12816/0008480
<strong>Background:</strong>As hepatitis C virus (HCV) infection is a major health problem in patients with end-stage renal disease (ESRD).
<strong>Aim:</strong>explore the response rate and adverse effects of pegylated interferon and ribavirin in treating HCV genotype 4 in patients withend stage renal disease (ESRD) waiting renal transplantation.
<strong>Patients &Methods:</strong>This study included 24 patients with ESRD and active HCV infection as detected by clinical, sonographic, biochemical, serological, virological and histological examination with liver biopsy. All patients were under hemodialysis with HCV antibodies positive > 6 months. Viral genotyping and both qualitative and quantitative PCR were carried out before starting therapy. Treatment was continued for 48 weeks using pegasys 135 µg weekly and ribavirin 200 mg daily. The biochemical and virological responses were evaluated regularly during and after treatment. The sustained virological response (SVR) being evaluated 24 weeks later. The side effects were monitored throughout the treatment period.
<strong>Results:</strong>Rapid virological response (RVR) after week 4 was achieved in 11/24 (46%) patients. The sustained virological response (SVR) was achieved in 16/24 (66.7%) patients. No break through or relapses were detected during and after treatment respectively. Correlation was found between the viral load before treatment and that at week 4 with p < 0.001and at 12 weekand between the reduction of hemoglobin and the reduction of viral load at week 12 with p < 0.045.
<strong>Conclusion:</strong>genotype 4 HCV patients with ESRD can be considered for therapy pre-operatively to overcome all the morbidities associated with persistence of HCV after renal transplantation provided that the general condition, the hematological parameters and all other factors of treatment allowed such therapy.
<strong> </strong>
<strong> </strong>
Pegylated Interferon alfa 2a,Ribavirin,HCV genotype 4,End-stage renal disease
https://ejhm.journals.ekb.eg/article_15548.html
https://ejhm.journals.ekb.eg/article_15548_de317494c3f0820e7f0173a8407e42ee.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
57
1
2014
10
01
Quantification of Non-Calcified and Calcified Coronary Plaques Using 64-Slice MDCT in Patients with Acute Coronary Syndrome
460
469
EN
Wahid Hussein
Tantawy
Radiodiagnosis Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Mounir Sobhy
Gerges
Radiodiagnosis Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Essam Mohamed
Abd El-Hafez
Radiodiagnosis Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
10.12816/0008481
<strong>Purpose:</strong> To investigate the accuracy of 64-row MDCT to analyze and quantify coronary arterial plaques in patients presented with acute coronary syndrome (ACS).
<strong>Patients and methods: </strong>Between April 2010 and December 2013, 50 patients presented with acute cardiac chest pain were categorized into 2 groups according to their diagnosis based on clinical evaluation, ECG findings and cardiac biomarkers; group A including patients with ACS and group B including patients with stable angina (SA). Both groups underwent 64-row multidetector CT (MDCT) coronary arterial imaging. For each plaque, stenosis percentage was evaluated and the plaque was quantified using software (Sureplaque®) based on the density (HU) and percentage of its individual components including lipid, soft tissue, and calcium density.
<strong>Results: </strong>Of the 50 patients; 24 and 26 were grouped into groups A & B respectively. The mean value of stenosis percent of the proximal & middle coronary segments of group A patients = 77.2% ± 10.2% - 90.5% ± 58.4% and 79.5% ± 9.1% - 85.25% ± 11% respectively, while in group B = 54.1% ± 12.1% - 65.2% ± 18.4% & 53.3% ± 1.5% - 68.6% ± 11.7% respectively (p=0.00-0.001). Quantification showed a mean value of lipid content percentage of group A = 15.4% ± 0.8% - 47.7 % ± 19.2 %, while in group B = 7.2% ± 5.5% - 10.3% ± 8.2% (p=0.008–0.001). The mean value of soft tissue content percentage in group A = 15.4% ± 0.8% - 47.7 % ± 19.2 %, while in group B = 7.2% ±5.5% - 10.3% ± 8.2%. The calcification content percentage in group A = 18% ± 8.7% - 35.1 % ± 16 %, while in group B = 66.4% ± 13.8% - 76.7% ± 16.5%.
<strong>Conclusion:</strong> 64-row MDCT angiographic quantification software provides a good basis for the future attempts of proper risk stratification of patients with coronary artery disease especially those liable for developing ACS.
<strong> </strong>
Acute Coronary Syndrome,Stable angina,coronary plaques,coronary MDCT angiography,plaque quantificatio
https://ejhm.journals.ekb.eg/article_15550.html
https://ejhm.journals.ekb.eg/article_15550_91bb9849e95ae535563e8f30a98a2163.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
57
1
2014
10
01
The Possible Rescue Effect of Vitamin E or Silymarin on Lung Tissue of Male Albino Rats Exposed to Electro-Magnetic Field
470
481
EN
Abir Khalil
Mohamed
Department of Zoology, Faculty of Science, Al-Azhar University, Cairo
amohamed_04@yahoo.com
10.12816/0008482
<strong>Aim of the work:</strong> Investigation of the histological and histochemical changes in the lung of male albino rats exposed to mobile phone radiation and the possible protective role of vitamin E or Silymarin.
<strong>Material and Methods: </strong>The present study was carried out on 36 adult male albino rats (<em>Sprague dawly</em>); they were divided equally into 6 groups (C group: control rats; R group: rats exposed to 900 MHz (2h /day) of radiofrequency electromagnetic field (RF-EMF) radiation; S group: positive control rats given Silymarin; E group: positive control rats given Vitamin E; R+S group: rats treated with Silymarin post EMF irradiation and R+E group treated with vitamin E post EMF irradiation).
<strong>Results:</strong> Rats exposed to mobile phone radiation showed numerous histological and histochemical changes; these changes were ameliorated by using vitamin E or Silymarin. Vitamin E showed anti-damaging effect of lung tissue exposed to mobile phone radiation more than Silymarin.
<strong>Conclusion:</strong> The present study showed that the natural anti-oxidant Silymarin and vitamin E could protect the lung tissue from the damage produced after the exposure to mobile phone radiation. Vitamin E showed significant anti-damaging effect more than the anti-damaging effect of Silymarin.
<strong> </strong>
Mobile phone,Radiations,lung,histology,histochemistry,albino rats
https://ejhm.journals.ekb.eg/article_15552.html
https://ejhm.journals.ekb.eg/article_15552_4b060b5cc9431d99a64298cee451d0ef.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
57
1
2014
10
01
Effects of Iron Chelating Therapy And/or HBV- Vaccination On β-Thalassemia Major Patients
482
493
EN
Eman G.
Helal
Zoology Department, Faculty of Science, Al-Azhar University (Girls)
Ali F.M.
El-Sayed
Virology Sector Research Unit, VACSERA. Egypt
Nahla G.
Mohamed
Virology Sector Research Unit, VACSERA. Egypt
Mona A.M.
Ahmed
Virology Sector Research Unit, VACSERA. Egypt
Mohammad Abulhasan
Zoair
Department of physiology, Omar Al-Mokhtar University, Albydaa,Libya
10.12816/0008483
<strong>Introduction</strong>: Thalassemia is a genetic inherited blood disorder in which the body makes abnormal hemoglobin with excessive destruction of red blood cells, which leads to anemia. For many years, hepatitis B virus was a major problem for patients with thalassemia substantially contracted from blood transfusions. The development of effective vaccine has further reduced the magnitude of the problem of hepatitis B. Iron chelators are used to remove excess iron that accumulates due to repeated blood transfusion.
<strong>Aim of the work</strong>: To compare thalassemic patients either have or haven’t HCV with healthy persons as regards biochemical indices taking in consideration effect of vaccination against HBV or not and using iron chelating therapy or not by the studied persons.
<strong>Methodology</strong>: A case control study in which 40 thalassemic, blood transfusion dependent patients were chosen randomly to act as a case group from thalassemic patients attending the VACSERA Company. The cases (40 patients) they were classified to patients having HCV, patients were HBV vaccinated ,other non vaccinated, using iron chelating therapyor don’t use it. Another 10 healthy and non thalassemic persons were chosen randomly among persons attending the same company as a control group to be matched with the case group.
<strong>Results:</strong> 50% of studied thalassemic patients had HCV seropositivity. Biochemical blood indices which were found to be significantly elevated among thalassemic patients than controls were ALT, AST, ALP, GGT and LDH enzymes in addition to serum iron, ferritin and globulin mostly in HBV non-vaccinated and iron chelating therapy non dependent patients while, other biochemical indices which were significantly decreased among thalassemic patients compared to controls included: total cholesterol, total protein, albumin and albumin/globulin ratio mostly in HBV vaccinated and iron chelating non dependent patients.
<strong>Conclusion</strong>: this study illustrated the effectiveness of iron chelators agentsand the importance of vaccination for reduction of morbidity and mortality.
https://ejhm.journals.ekb.eg/article_15556.html
https://ejhm.journals.ekb.eg/article_15556_fcc5fc0b90f7bc6293def81579543c3a.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
57
1
2014
10
01
Anastomotic Leakage After Gastrointestinal Surgery: Risk Factors, Presentation And Outcome
494
512
EN
Hamed Ahmed Abd El Hameed
El-Badawy
Department of General Surgery, Faculty of Medicine for Girls,
Al Azhar University Cairo, Egypt
10.12816/0008484
<strong>Background: </strong>Intestinal anastomosis is one of the most commonly performed surgical procedures, especially in the emergency setting and is also commonly performed in the elective setting when resections are carried out for benign or malignant lesions of the gastrointestinal tract. Anastomotic leak after gastrointestinal anastomosis is one of the important postoperative complication that leads to significant morbidity and adversely affects length of hospital stay.
<strong>Objective:</strong> To define the risk factors, presentation and outcome of anastomotic leakage after gastrointestinal anastomosis.
<strong>Methods: </strong>Prospective data collection from patients who underwent small or large bowel resection and anastomosis without fecal diversion in the surgical department in Al Zahraa University Hospital in the period between November 2010 and April 2014. Demographic details of the patients as well as preoperative, intraoperative and postoperative data were recorded. Leak found or not and on which postoperative day leak found. How it was identified (clinical or radiological) and how it was treated. Outcome of patients was recorded as mortality rate and postoperative hospital stay.
<strong>Results:</strong> There were 70 (63.64%) males and 40 (36.36%) female patients. Mean age was (44.23 ± 15.78) years. Anastomotic leak was occurred in 17 (15.4%) patients group I, while there was no leak in 93 patients (84.6%) group II. The mean postoperative period for diagnosis of anastomotic leakage was 9 days range (5-16) days.
Categorical variable found to be significantly affecting the outcome of anastomosis were age of the patients (<em>P</em>£0.001), smoker versus nonsmoker (<em>P</em>£0.0001), preoperative chemotherapy, radiation and anti T.B. (<em>P</em>£0.001), type of surgery elective versus emergency (<em>P</em>£0.05). Bowel preparation done in 73 versus not done in 37 (<em>P</em>£0.05), level of anastomosis small bowel and choledocojejunostomy versus gastrojejunstomy and large bowel (<em>P</em>£0.001), left versus right side colonic anastomosis (<em>P</em>£0.05). Intraoperative blood loss (<em>P</em>£0.0001). Blood transfusion >2 unit (<em>P</em>£0.0001).
Mortality rate was (29.41%) 5/17 in group I, while it was (3.23%) 3/93 in group II. The postoperative hospital stay was (24.7 ± 5.92) days in group I, while for group II it was (12.83 ± 3.8) days.
<strong>Conclusion: </strong>Postoperative gastrointestinal anastomotic leak is a very serious complication that has great clinical impact on patients, putting surgeons in dilemmas of detection and management.
There is multiple risk and predictive factors associated with occurrence of leak were suspected in this study such as: older patients, preoperative anemia, hypoalbuminemia, immunosuppressive therapy, smoking, surgery performed in an emergency setting, without adequate bowel preparation, long operative time, intraoperative blood loss and blood transfusion and low pelvic anastomosis, but many factors remain unclear. The presentation of anastomotic leakage varying from severe peritonitis and leakage of bowel content through the wound or from the drain to asymptomatic (small pelvic abscess).
Early detection and expediently treatment is very helpful to improve the patients outcome but death after leak is most often a substitute for a critically ill patients and was infrequently the actual cause of death and so every effort needs to be made to bring down the mortality rates and hospital stay associated with anastomotic leak.
<strong> </strong>
Anastomotic leakage,gastrointestinal surgery,risk factors
https://ejhm.journals.ekb.eg/article_15558.html
https://ejhm.journals.ekb.eg/article_15558_42b3b88f886e28aaad73ec384ff4781f.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
57
1
2014
10
01
The Effects of Jasonia montana (Neheda) on Some Biochemical and Histological Parameters of Diabetic Albino Rats
513
530
EN
Eman G. E.
Helal
https://orcid.org/0
Department of Zoology, Faculty of Science (Girls), Al-Azhar University, Cairo, Egypt
emanhelal@hotmail.com
Nouran
Abou-Aouf
Department of Zoology, Faculty of Science (Girls), Al-Azhar University, Cairo, Egypt
Sayda M.
Khattab
Department of Zoology, Faculty of Science (Girls), Al-Azhar University, Cairo, Egypt
Hassan S.
Shaibah
Anatomy Department, Faculty of Medicine, Umm Al-Qura University, KSA
Hoda M.
Abu-Taleb
Department of Enviromental Research, Theodor Bilharz Research Institute, Cairo, Egypt
Tamer M. M.
Abu-Amara
Histology and Cytology Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
10.12816/0008485
Diabetes mellitus is one of the common and widely distributed metabolic diseases all over the world. This disease is characterized by hyperglycemia that results from defects in insulin secretion, insulin action or both. In Asia, different medicinal plant species are used as a traditional treatment for diabetes mellitus e.g. <em>Jasonia montana </em>(Neheda) was one of these plants that was used in a mixture to treat diabetic patients long times ago.
<strong>Aim of the work:</strong> This work was aimed to investigate the antidiabetic, hypolipidemic and antioxidant effects of the aqueous extract of <em>Jasonia montana </em>(Neheda) on the alloxan-induced diabetic male albino rats.
<strong>Material and Methods: </strong>This study was performed on thirty male albino rats with an average 100-110 g body weight. The animals were divided into three groups (10 /cage); <strong>Group I</strong> (Control untreated group), <strong>Group II</strong> (Alloxan-induced diabetic group) and <strong>Group III</strong> (diabetic group treated orally with “28.5 mg/ kg body wt. twice/ day” of the plant extract).
<strong>Results: </strong>The biochemical results showed marked decline (p<0.01) in levels of the serum insulin, body weight, total proteins, albumin, globulin and HDL accompanied with marked elevation (<em>p</em><0.001) in the levels of fasting blood glucose, levels of HOMA_IR, AST, ALT, GGT, urea, creatinine, uric acid, serum TC, TG, LDL, VLDL and ratios of TC/HDL and LDL/HDL (risk factors) in diabetic rats in comparison with the control group. Daily management of diabetic rates with aqueous extract of Neheda showed significant improvement in most of these parameters. Histologically, considerable improvement in the morphological changes that was observed in diabetic groups had been detected after treatment with Neheda in liver, kidney and pancreatic tissues in comparison to the control group.
<strong>Conclusion: </strong>It could be concluded that <em>Jasonia montana </em>(Neheda) can be used as an antidiabetic drug that can lower blood glucose concentration and guard against the negative effects of diabetes<em>.</em>
<strong> </strong>
<strong> </strong>
Diabetes mellitus,alloxan,hyperglycemia,Neheda,Jasonia montana
https://ejhm.journals.ekb.eg/article_15625.html
https://ejhm.journals.ekb.eg/article_15625_35cd4c9030c88a9a2d64df51f1732721.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
57
1
2014
10
01
The Role of Different Photoperiods in the Activation of the Thyroid Gland and Ovaries of Adult and Aged Rats ( Rattus norvegicus )
531
546
EN
Gabry
M.S
Zoology and Entomology Department, Faculty of Science, Helwan University, Egypt.
El-Hennamy
R.E
Zoology and Entomology Department, Faculty of Science, Helwan University, Egypt
Ibrahim
M.A
Zoology and Entomology Department, Faculty of Science, Helwan University, Egypt
and Fathalla
A.S
Zoology and Entomology Department, Faculty of Science, Helwan University, Egypt
10.12816/0008486
<strong>Back ground</strong>: Many animals use the length of the day (photoperiod) to predict and adjust to seasonal changes in the environment through predictive changes in physiology and behaviour. The present work is designed to study the effect of different photoperiod regimes, i.e., short photoperiod 10L:14D, long photoperiod 14L:10D and 12L:12D light-dark cycle (LD) on the structure and hormonal secretion of the thyroid gland and ovaries in adult and aged female rats. <br /> <strong>Material and methods</strong>: The rats were divided into 6 groups, each group contained 6 adults (6 months old) or aged rats (18 months old) and maintained for one month under different photoperiod regimes.<br /> <strong>Results:</strong> Short and long photoperiods increased the activity of the thyroid gland of the adult rats. This gland was full of small follicles lined with simple columnar epithelium. Serum thyroxin levels were extremely higher in long photoperiod group than that observed in 12:12LD and short photoperiod groups. In contrast short photoperiod induced an increase in serum thyroxin level in the aged rats. Short photoperiod and 12:12 LD cycle enhanced gonadal activity of the adult rats. The ovary contained clusters of primordial follicles, different stages of ovarian follicles, and, few numbers of atretic follicles. In the groups of the aged rats all the stages of the ovarian follicles exhibited signs of atresia in such groups. LH, FSH, progesterone and estrogen were increased mainly in the control group in adult and aged rats compared to the photoperiod groups. From the present result we could conclude that: 12:12 light dark cycle enhanced the structural and functional activities of ovaries in adult rats, while aging decreased their activities. In contrast, long photoperiod induced thyroid gland activities in adult rats while short photoperiods activated the gland of aged rats.
Photoperiod,Thyroid gland,thyroxin,Ovary,Female hormones,rat
https://ejhm.journals.ekb.eg/article_15627.html
https://ejhm.journals.ekb.eg/article_15627_d74ce7a17c72e666de8ca20ef48c1a96.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
57
1
2014
10
01
Correlation between the Level of Vitamin D and Bone Mass Index in Primary Osteoporotic Patients in Taif-KSA
547
553
EN
Nagy A.
Seleem
Department of Orthopedic and Traumatology, Faculty of Medicine, Al-Azhar University
Azza A.
Taha
Department of Public Health and Community Medicine, Faculty of Medicine, Menoufyia University
Amal A.
Soliman
Department of Clinical Pathology, Faculty of Medicine, Menoufyia University, Egypt.
Nehal M.
Salama
Department of Internal Medicine, Collage of Medicine, Taif University, Saudi Arabia.
10.12816/0008487
Osteoporosis (OP) is considered as one of the commonest metabolic bone diseases in orthopedics, characterized by a reduction in bone mass density and micro-architectural deterioration of bone tissue leading to diminished material properties with an increase in bone fragility and susceptibility to minor trauma fractures.
<strong>The aim of this cross sectional study was</strong> to detect the level of vitamin D in patients suffering from primary osteoporosis and to correlate their levels with bone mass index. This work was performed - at the Orthopedic Outpatient Clinic of King Abdul Aziz specialist Hospital, Taif, (KSA) - on 115 patients (77 females and 38 males) fulfilling WHO revised criteria of 1994 for osteoporosis. The mean age of patients was 67.5± 8.2. A medical history was taken and bony pains, fragility fractures, and loss of height, were elicited, with Inclusion criteria in the form of a T-score ≤ −2.5 SD at the lumbar spine, with exclusion of any patient with secondary osteoporosis. Full physical examination and investigations were done including estimation of serum total vitamin D and X-ray of lumbar and thoracic spine.
<strong>Results indicate that</strong> the mean total vitamin D and T-score were 19.7±6.6 ng/dl and -2.9± 0.4 respectively. 88.7% of osteoporotic cases were complaining of bone pains, 47% of them complaining of height loss and 47.8% of them had spine fracture in X-ray. Positive strong significant correlation between total vitamin D and T-score (r=0.83, p value <0.0001) was found. <strong>It could be concluded that</strong> there is a significant positive strong correlation between total vitamin D and bone mass index in primary osteoporotic patients in Taif - KSA.It is recommended that adequate intake of calcium and vitamin D during prophylaxis and treatment of osteoporosis is necessary.
<strong> </strong>
Vitamin D,BMI,Osteoporosis
https://ejhm.journals.ekb.eg/article_15629.html
https://ejhm.journals.ekb.eg/article_15629_9fe09a7266b7afa858e5627dca8d7216.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
57
1
2014
10
01
Cytotoxicity of Silver Nanoparticles in Mice Liver Cells: An Ultrastructure Study
554
564
EN
Ola H.
El-Habit
Faculty of Science, Zoology and Entomology Department, Helwan University, Egypt
Eman A.
Mousa
Faculty of Science, Zoology Department, Kafr El-sheikh University, Egypt
Basma N.
Hassan
Faculty of Science, Zoology and Entomology Department, Helwan University, Egypt
<strong> Introduction:</strong> Nanoparticles of silver have many important applications and are among the most commonly used nanomaterials. They are increasingly used in a variety of both medical and consumer products which includes: spectrally selective coating for solar energy absorption and intercalation material for electrical batteries, as optical receptors, polarizing filters, catalysts in chemical reaction and bio-labeling. Nanosilver (Ag-NP) has both antibacterial and antiviral activity. Yet, the knowledge about the systemic toxicity of nanosilver is relatively limited.
The aim of work: To evaluate the potential toxicity of small size 10nm silver nanoparticles using two different doses (0.1 ml and 0.4 ml) focusing on the ultrastructural changes occurring in mice hepatocytes.
<strong> The methods</strong>: This study was performed using three groups of mice. The animals of the first group were given a daily intravenous injection of 0.1 ml of silver nanoparticles for 28 consecutive days. The second group was treated with 0.4 ml of silver nanoparticles for 28 consecutive days. The third group served as a control group in which the animals did not receive any vehicle. The study was focused on the ultrastructure of the liver.
<strong> The results: </strong>Ultrastructure observations of liver cells of miceTreated with any of the two doses (0.1 and 0.4 ml) of 10 nm Ag-NP indicated severe accumulation of dark deposits of Ag-NP in the cytoplasm and the cell organelles.
<strong> Conclusion:</strong> Our study revealed that nanosilver used in doses of 0.1 and 0.4 ml led to deposits in the cells and induced damage of cell components especially the nucleus, mitochondria and chromatin.
<strong> </strong>
<strong> </strong>
nanosilver,Cytotoxicity,Liver,mitochondria
https://ejhm.journals.ekb.eg/article_15632.html
https://ejhm.journals.ekb.eg/article_15632_1a365499c83284a756e2b7119f1f3405.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
57
1
2014
10
01
Histpathological and Immunohistochemical Changes Induced by Contraceptive Pills in the Cervix of Female Rabbits
565
579
EN
Gabri
MS
Department of Zoology and Entomology, Faculty of Science, Helwan University.
Ibrahim
MA
Department of Zoology and Entomology, Faculty of Science, Helwan University
Abd El-kader
DH
Department of Histology, Faculty of Medicine, Cairo University
Hassan
BN
Department of Zoology and Entomology, Faculty of Science, Helwan University
10.12816/0018489
<strong>Introduction:</strong> oral contraceptive pills (OCPs) are the most popular form of hormonal contraception in young women. <br /> <strong>Aim of the work:</strong> the present study focused on evaluating the effects of two different contraceptive pills including combined pills (estrogen and progesterone) and mini pills (progesterone only) on the cervix of female rabbit. <br /> <strong>Material and methods:</strong> after three months of daily oral administration of these contraceptive pills the animals were sacrificed. The excised organs were dissected, processed and stained with H & E, PAS reaction and Masson’s trichrome stain and orcein stain. This was followed by morphometric measurements and statistical study. <strong>Results:</strong> this study revealed that contraceptive pills administration - specially the combined one - caused marked alterations in the form of hyperplastic cervical mucosal cells and hypertrophied muscular layer. Also, there was a significant increase in collagenous and elastic fibres content in the muscular layer of the cervix. There was also a statistically significant increase in PAS positive materials in the lumina of the mucosal glands of the cervix. All these changes were less marked in the case of mini pill treatment <br /> <strong>Conclusion:</strong> pills of progesterone only showed marked histopathological change, in the cervix as a contraceptive mean, but in less manner than the combined pills (estrogen and progesterone). <br /> <strong> </strong>
combined pills – mini pills – cervix – hyperplasia
https://ejhm.journals.ekb.eg/article_15635.html
https://ejhm.journals.ekb.eg/article_15635_89b1f35c8062cb0886e91050127fe261.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
57
1
2014
10
01
Effect of Crowding Stress on Lung and Heart of the Adult Albino Rats and the Possible Protective Role of Sulpiride
580
597
EN
Tamer M. M.
Abu-Amara
Histology&Cytology Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt
tamer4567@yahoo.com
Wagih M.
Abdelhay
Histology&Cytology Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt
Ayman F.
Elsharawy
Histology&Cytology Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt
Lotfy S.
Mohamed
Histology&Cytology Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt
Salah E.
Mourad
Anatomy & Embryology Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt
Abdelghany H.
Abdelghany
Anatomy & Embryology Department, Faculty of Medicine, Alexandra University, Egypt
Neama M.
Taha
Physiology Department, College of Medicine, Umm Al-Qura University, KSA.
10.12816/008490
<strong>Abstract</strong>: Exposure to crowding stress is associated with increased respiratory system morbidity, However, the underlying mechanisms are unclear. Thus, there is a need for more study of this harmful effect. Sulpiride had been shown to have a protective role against crowding stress on other systems but this role was not studied well on the respiratory and cardiovascular systems.<br /> <strong>Objectives: </strong>Investigating the possible harmful effects of crowding on adult albino rats' lung and heart and the possible protective role of combined sulpiride treatment.<br /> <strong>Materials and Methods: </strong>The present study was carried out on 24 adult albino rats of local strain weighing 120±3 g which were randomly divided equally into <strong>Group 1(C, untreated negative control), Group 2 (Cr, crowding exposed or positive control) </strong>where rats were exposed to crowding in a cage (20x20x20 cm- 6 rats /cage) for 1 month<strong>, Group 3(D, sulpiride-treated) </strong>where the rats were exposed to sulpiride “0.028 mg/B.W./day” and <strong>Group 4 (Cr+D, crowding + sulpiride-treated). </strong>Paraffin sections were prepared for histological, histochemical and morphometric studies. The data were statistically analysed.<br /> <strong>Results</strong>: The rats exposed to crowding only or sulpiride only showed highly significant damaging changes on lung such as thickening in the interalveolar septa and obliteration of the alveoli, inflammatory cells infiltration within the pulmonary interstitium, peribronchiolar infiltration and fibrosis, thickening of the pulmonary blood vessels walls, interstitial collagen fibres deposition and apoptotic cellular changes. On the level of heart, significant decrease in the diameters of the myocardial muscle fibres with focal areas of necrosis, apoptotic changes and increased collagen fibres deposition was marked in sulpiride group. When crowding and sulpiride treatments were combined, the damaging effects were maximized on the lung and heart.<br /> <strong>Conclusion</strong>: These results provided evidence that crowding stress causes obvious lung and heart tissue damages. No protective role for sulpiride was proofed. This is because using sulpiride alone or in combination with crowding showed marked damaging effects on the lung and heart tissues.<br /> <strong> </strong>
crowding,Sulpiride,lung,heart,Stress,Histology and Histochemsitry
https://ejhm.journals.ekb.eg/article_15638.html
https://ejhm.journals.ekb.eg/article_15638_8340bd5fef4559f8e841d900b83bc155.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
57
1
2014
10
01
Histological and Biochemical Evaluation of the Effects of Some Antioxidants on Aged Testes
598
611
EN
Maiada
Moustafa
Department of Zoology and Entomology, Faculty of Science, Helwan University
Ahmed Said
Alazzounui
Department of Zoology and Entomology, Faculty of Science, Helwan University.
Mohamed Said
Gabri
Department of Zoology and Entomology, Faculty of Science, Helwan University.
10.12816/0008491
<strong>Background:</strong> Different studies have demonstrated that aging clearly affects male fertility which may be attributed to the androgen deficiency. Reactive oxygen species play a central role in the pathophysiology in the aged-related decrease in male fertility. Some antioxidants have ameliorative effects on different aged organs.<br /> <strong>Material and Methods:</strong> The present study aimed to evaluate the effects of some antioxidants on aged testes. Ten adult and fifty aged male albino rats (<em>Rattus albus</em>) were divided into six groups. Group I (control adult), Group II (control aged), Group III (Vitamin E-treated aged), Group IV (Vitamin C-treated aged), Group V (Zinc sulphate-treated aged), Group VI (Vitamin E-, Vitamin C- and Zinc Sulphate-treated aged). Vitamin E, Vitamin C and Zinc were administrated in doses 2.52 mg, 3.15 mg and 0.693 mg, respectively. Histological and ultrastructural evaluation of the testes were examined as well as Follicle stimulating hormone (FSH), Luteinizing hormone (LH), total and free testosterone levels in the serum were measured. Counting the number of litters per animal and the teratogenic effects was noticed. <strong>Results:</strong> Giving zinc alone or combined with other antioxidants gave better ameliorative effects on the testicular structure and hormonal levels in the serum. No teratogenic effects of the aged animals`offspring were noticed.<br /> <strong> </strong>
aging,testis,zinc,Vitamin E,vitamin c,combined antioxidants
https://ejhm.journals.ekb.eg/article_15641.html
https://ejhm.journals.ekb.eg/article_15641_e99e3c772855d19935581c2f7d00b429.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
57
1
2014
10
01
The Effects of Ambrosia maritime, L. (Damsissa) on Some Biochemical and Histological Parameters of Diabetic Albino Rats
612
629
EN
Eman G. E.
Helal
https://orcid.org/0
Department of Zoology, Faculty of Science (Girls), Al-Azhar University, Cairo, Egypt
emanhelal@hotmail.com
Nouran
Abou-Aouf
Department of Zoology, Faculty of Science (Girls), Al-Azhar University, Cairo, Egypt
Sayda M.
Khattab
Department of Zoology, Faculty of Science (Girls), Al-Azhar University, Cairo, Egypt.
Abd EL Razek A.
Meselhy
Anatomy and Embryology Department, Faculty of Medicine, Al-Azhar University, Assiut, Egypt.
Tamer M. M.
Abu-Amara
Histology and Cytology Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt
tamer4567@yahoo.com
10.12816/0008492
Diabetes mellitus is one of the common and widely distributed metabolic diseases all over the world. This disease is characterized by hyperglycemia that results from defects in insulin secretion, insulin action or both. Different medicinal plant species are used as a traditional treatment for diabetes mellitus e.g. <em>Ambrosia maritima</em>, L. (Damsissa) which is one of these plants that its extract was used to treat diabetic patients long times ago.
<strong>Aim of the work:</strong> This work was aimed to investigate the antidiabetic, hypolipidemic and antioxidant effects of the aqueous extract of <em>Ambrosia maritima</em>, L. (Damsissa) on the alloxan-induced diabetic male albino rats.
<strong>Material and Methods: </strong>This study was performed on thirty male albino rats with an average 100-110 g body weight. The animals were divided into three groups (10 /cage); <strong>Group I</strong> (Control untreated-group), <strong>Group II</strong> (Alloxan-induced diabetic group) and <strong>Group III</strong> (diabetic group treated orally with “28.5 mg/ kg body wt. twice/ day” of the plant extract).
<strong>Results: </strong>The biochemical results showed marked decline (p<0.01) in the levels of the serum insulin, body weight, total proteins, albumin, globulin and HDL accompanied with marked elevation (<em>p</em><0.001) in the levels of fasting blood glucose, levels of HOMA_IR, AST, ALT, GGT, urea, creatinine, uric acid, serum TC, TG, LDL, VLDL and ratios of TC/HDL and LDL/HDL (risk factors) in diabetic rats in comparison with the control group. Daily management of the diabetic rates with aqueous extract of Damsissa showed significant improvement in most of these parameters. Histologically, considerable improvement in the morphological changes that was observed in diabetic groups had been detected after treatment with Damsissa in liver, kidney and pancreatic tissues in comparison to the control group.
<strong>Conclusion: </strong>It could be concluded that <em>Ambrosia maritima</em>, L. (Damsissa) can be used as an antidiabetic drug that can lower blood glucose concentration and guard against the negative effects of diabetes<em>.</em>
<strong> </strong>
Diabetes mellitus,alloxan,hyperglycemia,Damsissa,Ambrosia maritima
https://ejhm.journals.ekb.eg/article_15644.html
https://ejhm.journals.ekb.eg/article_15644_bceb559c16a4f576a775e2702bf0c04f.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
57
1
2014
10
01
Influence of Maternal Anemia on Placental Volume with Study of Uterine Artery Doppler
630
638
EN
Fatma M.
El-Sokkary
Obstetrics & Gynecology Faculty of Medicine for Girls Al-Azhar university
MadihaM.
Hanafy
Obstetrics & Gynecology Faculty of Medicine for Girls Al-Azhar university
Hanan Abd Elmonem
Mohamed
Obstetrics & Gynecology Faculty of Medicine for Girls Al-Azhar university
10.12816/0008493
<strong>Objectives: </strong>To study the influence of maternal hematocrit(Ht) and hemoglobin (Hb) levelon placental volumewithstudy ofuterine artery Doppler.
<strong>Subjects and Methods:</strong> In this prospective study 40 pregnant( singleton pregnancy) cases were selected from the outpatient clinic of Alzahra university Hospital. They were divided into two groups the study group (20 cases)were anemic( iron deficiency) and the control group( 20cases) were healthy. For each case two scans for the placenta and fetal growth were performed, the first at recruitment and the second 5 weeks later. Placenta volume was measured at each visit using three dimensional ultrasound. The maternal Hb and ( Ht) were measured in each visit.
<strong>Results:</strong> It revealed a non statistical significance between maternal hemoglobin, hematocrit and placental volume during the 1st visit and 2<sup>nd</sup> visit in anemic group compared to the control group.As regards Doppler study of the uterine artery in the present study it was noted that the pulsatility index and resistance index showeda non significant increase in the anemic group compared to the control group.
<strong>Conclusion:</strong>Maternal iron deficiency anemia can affect placental growth and development. Placental volume increased with mild anemia during the first trimester but has no significant effect of fetal growth.The use of 3D ultrasound is more accurate and efficient safe technique of great value in evaluating placental growth and volume. Also, the study of uterine artery blood flow during the mid second trimester showed a nonsignificant increase of RI and PI with maternal anemia. Further study are needed for the effect of anemia on fetal growth during preconceptional, first,second,third trimester and the outcome of pregnancy.
<strong> </strong>
Maternal anemia,Placental Volume,uterine artery Doppler
https://ejhm.journals.ekb.eg/article_15648.html
https://ejhm.journals.ekb.eg/article_15648_81c1bd858ac8cacf730fb28b20a493e3.pdf