Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
65
1
2016
10
01
Role of Vitamin D in the Induction of Regulatory T Cells Producing Interleukin 10 in Children with Cow Milk Allergy
454
467
EN
Randa Reda
Mabrouk
Chemical Pathology Ain Shams University
Hana Ahmed
Amer
Chemical Pathology Ain Shams University
Dina Ahmed
Soliman
Clinical and Chemical Pathology Ain Shams University
Nesrine Aly
Mohamed
Dalia Helmy
El-Ghoneimy
Pediatric, Faculty of Medicine – Ain Shams University
Sara Mohammad
Atef
10.12816/0033753
<strong>Background:</strong> Various populations of regulatory T cells play a central role in the development of peripheral tolerance to allergens. Culturing of CD4+ T cells isolated from peripheral blood of allergic patients with vitamin D induces the generation of stable IL-10 producing CD4+CD25+ Treg cells suppressing the proliferation of T helper cells obtained from the same patients. The immune regulatory role of vitamin D in allergic patients has been controversial and obviously needs a more clarifying research work. <strong>Aim of the work:</strong> to determine the percentage of induced T regulatory cells producing interleukin 10 after stimulation of T regulatory cells with cow milk allergen in the presence of vitamin D in culture. This aims to further in-vitro study the immune regulatory role of vitamin D in cow milk allergic patients. <strong>Results:</strong> there is association between decreased level of vitamin D and milk-allergy, as serum level of 25(OH) D3 was insufficient in 16 (80 %) patients (10- 29.9 ng/ml) while 4 (20%) patients were sufficient (30-100 ng/ml). Addition of vitamin D, in culture, induces the production of CD4+ CD25hi Foxp3+ IL10+ .
Treg cells within peripheral blood mononuclear cells (<span style="text-decoration: underline;">PMNCs)</span> isolated from allergic children who had insufficient vitamin D, but not in allergic children who had normal level of vitamin D.
<strong>Conclusion:</strong> this work provides further evidence for an important role of 1,25(OH)2D3 as an immune-modulatory molecule and suggests that supplementation of vitamin-D-deficient individuals, who are reported to have reduced numbers of circulating and Foxp3<sup>+ </sup>IL10<sup>+</sup> Treg cells, may represent an attractive therapy for enhancing endogenous populations of Treg cells in allergy.
<strong> </strong>
Regulatory T cells,calcitriol,Food allergy
https://ejhm.journals.ekb.eg/article_15084.html
https://ejhm.journals.ekb.eg/article_15084_be336fe298ab03d4f575902f6b495368.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
65
1
2016
10
01
Use of Onion and Curcumin as Radioprotectors against Ionizing Radiation Induced Hepato-Testicular Alterations in Rats
468
473
EN
Amal A. A.
Ammar
Medical and Radiation Research Department,Nuclear Materials Authority, Cairo, Egypt
10.12816/0033754
<strong>Background:</strong> radiation protection concepts and philosophy have been evolving over the past several decades. The inadvertent exposure of human from various source of radiation causes ionization of molecules, setting off potentially damaging reactions via free radicals production. Onion, Allium cepa linn, is a major source of dietary flavonoids and has used since ancient times as a food plants. Curcumin is a yellow pigment from curcuma longa, is a major component of turmeric and has commonly used as a spice and food coloring materials<strong>.</strong><strong> Aim: </strong>the aim of the present study is to evaluate the radioprotective role of both onion and curcumin extracted as antioxidant against gamma irradiation that induced some biochemical alterations in rats.
<strong>Materials and Methods: </strong>animals were pretreated with onion or curcumin by orally administration using suitable stomach tube for two weeks prior to radiation exposure. The levels of malondialdhyde (MDA), glutathione content (GSH), superoxide dismutase (SOD), glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT) and testosterone were estimated in both serum and tissues.<strong> Results: </strong>the results revealed that exposure to ionizing radiation resulted in significant elevation in the levels of MDA, GOT and GPT activities, meanwhile, showed significant depletion in GSH content and SOD activity and testosterone concentration. <strong>Conclusion: </strong>administration of onion or curcumin by using suitable stomach tube pre-irradiation has significantly ameliorated the radiation induced disturbances in all of the investigated parameters.
<strong> </strong>
Ionizing radiation,Onion,Curcumin and Antioxidants
https://ejhm.journals.ekb.eg/article_15085.html
https://ejhm.journals.ekb.eg/article_15085_61ef103046d96dd495614a2dd288e8d9.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
65
1
2016
10
01
Ameliorative Effect of Vitamin E on Oxidative Stress Induced by Bisphenol A in Female Albino Rats
474
478
EN
Eman
Helal
https://orcid.org/0
AlAzhar univ.
emanhelal@hotmail.com
Neama M.
Taha
Physiology Department, College of Medicine
Ahmed M.
mohamed
Clinical Pharmacology Department, Faculty Of Medicine, Zagazig University
Hoda M.
Abu-Taleb
Department of Environmental Research, Theodor Bilharz Research Institute, Cairo, Egypt.
10.12816/0033755
<strong>Objective: O</strong>xidative stress is induced by bisphenol A (BPA) and affects many organs. Vitamin E is an effective antioxidant which prevents the activity of free radicals. This study was <strong>aimed</strong> to clarify the effect of vitamin E on the oxidative stress induced by chronic administration of BPA.
<strong>Materials and methods: </strong>30 female albino rats were divided into 3 groups (10/each); group1: control rats, group 2: rats treated with bisphenol A (20 mg/ kg.B.wt) for three months, and group 3: rats treated with bisphenol A (20 mg/kg.B.wt) for three months, then treated with BPA and vitamin E (0.57/100 g B.wt) for other 15 days. <strong>Results</strong>: BPA induced hormonal disrupt in liver and kidney dysfunctions and hyperlipidemia. Vitamin E ameliorated all these parameters. <strong>Conclusion:</strong> since we exposed to many harmful disruptions and oxidative stress compounds, we must take vitamin E as a protective agent.
<strong> </strong>
BPA,Vitamin E,sexual hormone,Liver,kidney,lipids
https://ejhm.journals.ekb.eg/article_15086.html
https://ejhm.journals.ekb.eg/article_15086_6069cd2cbe707046a6fc57b4710d2328.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
65
1
2016
10
01
Clinical Utility of Procalcitonin in The Prediction of Cardiovascular Complications in Patients with Type 2 Diabetes Mellitus
479
490
EN
Hanaa
Hamdy
Hormones Department,National Research Center
Wafaa
Ghoneim
Biochemistry Departments, Faculty of Science
Hatem
Abdelmonem
Biochemistry Departments, Faculty of Science
Ibrahim
Ali
Biochemistry Department, National Institute of Diabetes and Endocrinology
Marwa
Emam
Biochemistry Department, National Institute of Diabetes and Endocrinology
10.12816/0033756
Objective:this study was initiated to assess procalcitoninas prognostic marker forcardiovascular complication in type2 diabetic patients.
Subjects and methods:forty type 2 diabetic patients without cardiovascular disease, forty type 2 diabetic patients with cardiovascular disease and twenty healthy control counterparts were included in the present study. Serum procalcitoninlevels were assayed and correlated with metabolic parameters.ROC curve analysis was also done for this biochemical marker.
Results:the mean level of procalcitonin was 707.17± 99.19ng/l in diabetic subjects versus 881.30± 123.56ng/l for the cardio-diabetic subjects (<em>P </em>< 0.0001).Procalcitonin levels were significantly amplified in the cardio-diabetic patients with increasing C-reactive protein (CRP), triglycerides (TG), fasting blood glucose (FBG),and cholesterol (P = 0.004, 0.0005, 0.002 and 0.01 respectively). From ROC curve analysis, it was observed that the area under curve for procalcitoninwas 0.878. This finding indicates the good validity of the above biomarker as aprognostic factor for cardiovascular complication in type 2 diabetic patients.
Conclusion:this study evidences the usefulness of measuring serum levels of procalcitoninin diagnosis of cardiovascular complication in type 2 diabetic patients.
<strong> </strong>
Procalcitonin,Diabetes mellitus,Cardiovascular complications,prognosis
https://ejhm.journals.ekb.eg/article_15087.html
https://ejhm.journals.ekb.eg/article_15087_1bd80809f41bc1a6cc00c9ed30cd8c54.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
65
1
2016
10
01
Chemerin Novel Biomarker As a Prognostic Factor for Cardiovascular Complications in Type 2 Diabetic Patients
491
497
EN
Hanaa
Hamdy
Hormones Department, National Research Center, Giza (Egypt)
Wafaa
Ghoneim
Biochemistry Departments, Faculty of Science, Helwan University, Cairo (Egypt)
Hatem
Abdelmonem
Biochemistry Departments, Faculty of Science, Helwan University, Cairo (Egypt)
Ibrahim
Ali
Biochemistry Department, National Institute of Diabetes andEndocrinology, Cairo (Egypt).
Marwa
Emam
Biochemistry Department, National Institute of Diabetes andEndocrinology, Cairo (Egypt).
10.12816/0033757
Objective:the present study was aimed to assess chemerin as prognostic factor forcardiovascular complications in type2 diabetic patients.
Patients and methods:forty type 2 diabetic patients without cardiovascular disease, forty type 2 diabetic patients with cardiovascular disease and twenty healthy control counterparts were included in thepresent study.Chemerinlevels were assayed and correlated with clinical pathological parameters.ROC curve analysis was also done for this biochemical marker.
Results:the mean level of chemerinwas 57.65± 15.69 ng/l in diabetic subjects versus 93.97 ± 26.62 ng/l for the cardio-diabetic subjects (<em>P </em>< 0.0001)<em>.</em>The chemerin levels were significantly elevated in the cardio-diabetic patients with increasing-reactive protein(CRP), triglycerides(TG), fasting blood glucose (FBG), glycated hemoglbin(HbA1C), micro-albumin and cholesterol (P < 0.0001, P < 0.0001, P = 0.005, P=0.04, P=0.011andP=0.0001 respectively). From the ROC curve analysis, it was observed that the area under curve for chemerin was 0.877. This finding indicates the good validity of the above biomarker as aprognostic factor for cardiovascular complication in type 2 diabetic patients.
Conclusion:it could be concluded that chemerin can be used as prognostic biomarker for cardiovascular complications in type 2 diabetic patients.
<strong> </strong>
Chemerin,Diabetes mellitus,cardiovascular complication,prognosis
https://ejhm.journals.ekb.eg/article_15090.html
https://ejhm.journals.ekb.eg/article_15090_5d87badab233a46982065f7788acdbb5.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
65
1
2016
10
01
Facial Dimploplasty: Open Surgical Access Case series
498
503
EN
Muhammad
Helal
Plastic Surgery Department, King Faisal Medical Complex, Taif, KSA
Khalid
Al-Shareef
Plastic Surgery Department, King Faisal Medical Complex, Taif, KSA
Mohamed
Abdelaaty
Plastic Surgery Department, King Faisal Medical Complex, Taif, KSA
Shatha
ALqahtani
Plastic Surgery Department, King Faisal Medical Complex, Taif, KSA
10.12816/0033758
<strong>Background:</strong> Facial dimples are common findings in the human face and always have been considered a sign of facial beauty.<br /> With the increased awareness of plastic surgery ,there are also an increased in the willingness to have surgically created dimples. Multiple surgical techniques have been described for creating facial dimples.<br /> The open surgical technique for facial diploplasty gives proper visual access for mimicking the natural dimples rather than the blind coring of the tissues or the transcutaneous sutures as both are associated with more risk of unwanted complications or side effects.<br /> <strong> </strong>
Dimple,dimple surgery,Sutures
https://ejhm.journals.ekb.eg/article_15092.html
https://ejhm.journals.ekb.eg/article_15092_04c732344a64201027bad6e72807ee0d.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
65
1
2016
10
01
An Analysis of Micronuclei and DNA Damage Induced by Methotrexate Treatment of Male Albino Mice
504
514
EN
Nagla Zaky Ibrahim
El-Alfy
Biological and Geological Sciences Department,Faculty of Education, Ain Shams University, Cairo,
naglaelalfy@hotmail.com
Amany Ibrahim
Alqosaibi
Biology Department, Science College, University of Dammam, Dammam, Saudi Arabia
Mahmoud Fathy
Mahmoud
Biological and Geological Sciences Department,Faculty of Education, Ain Shams University, Cairo
Sally Ramadan Gabr
El-Ashry
Biological and Geological Sciences Department,Faculty of Education, Ain Shams University, Cairo
10.12816/0033759
<strong>Background:</strong> Methotrexate is an antineoplastic, antipsoriatic and antirheumatic agent belongs to the group of antimetabolites and inhibits folic acid metabolism. <strong>Materials and methods:</strong> To investigate its possible effect, sixty male mice were randomly assigned to one of four groups (one control and three treated groups with different doses of methotrexate). Mice of groups 1, 2 and 3 were intraperitoneally injected with 2.5, 5 and 10 mg /kg b.wt. methotrexate respectively. All the control and treated animals were sacrificed at 24, 48 and 72 hour by cervical dislocation post treatment. <strong>Results</strong><strong>:</strong>Micronucleus assay results showed that methotrexate treatment induced genotoxicity in bone marrow cells, the number of micronucleated polychromatic erythrocytes (MNPCEs) and the ratio of polychromatic erythrocytes / normochromatic erythrocytes was gradually increased significantly (P < 0.001) by increasing dose and time of treatment in methotrexate treated groups in comparison with the control group. An analysis of randomly amplified polymorphism DNA-polymerase chain reaction<strong> (</strong>RAPD-PCR) showed different ranges of DNA modifications in the treated groups after 24, 48 and 72 hour of treatment in comparison with the control group. Results of this study indicate that methotrexate treatment induced cytotoxic and genotoxic effect on bone marrow cells and DNA content of male albino mice even after a low dose and single treatment. <strong>Conclusion:</strong> Therefore, the therapeutic uses of methotrexate should be restricted to a very narrow range border.
<strong> </strong>
DNA,Mice,Methotrexate,Micronuclei,RAPD-PCR
https://ejhm.journals.ekb.eg/article_15094.html
https://ejhm.journals.ekb.eg/article_15094_ee59662245cbc49930193ef66da5d6d7.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
65
1
2016
10
01
Interactions between Gabapentin and Cisatracurium in Experimental Animals and in Patients Undergoing Spinal Surgeries
515
525
EN
Zeinab
Bayomy
department of Anesthesiology & Intensive Care Faculty of Medicine, Alazhar University.
Enas
Abdel Aty
department of Pharmacology Faculty of Medicine, Alazhar University.
Mahmoud
Farid
department of Neuro surgery Faculty of Medicine, Alazhar University.
10.12816/0033760
<strong>Background:</strong> gabapentin was originally discovered over 40 years ago by the Japanese, who initially were looking for an antispasmodic or muscle relaxant, but, later it was used as an antiepileptic and multimodal perioperative drug. <strong>Objective </strong>of this randomized study is to assess the some cardiovascular effects of gabapentin as well as its effect on the neuromuscular blockade induced by Cisatracurium. The interactions between both of them was also done in cats and rats & in patients undergoing elective spinal surgeries. <strong>Materials & Methods: </strong>The pharmacological study was carried out at the pharmacological lab of Al-Azhar University. The effect of different doses of cisatracurium (0.25 -4 µg/ml) and Gabapentin (6-96 µg/ml) & interactions between gabapentin (24µg/mL) and cisatracurium (0.25-4 µg/mL) were also done to test the effect on the amplitude of contraction of isolated Rat phrenic nerve -diaphragm preparation. Effect of intravenous (IV) injection of cisatracurium (1-16 mg/kg) and Gabapentin (15-240 mg/kg) and interactions between gabapentin (60mg/kg) and cisatracurium (1-16 mg/kg) on mean arterial blood pressure (MAP) and electrocardiogram (ECG) were also studied on anesthetized cats. Each experiment was done on six preparations. The <em>clinical Study</em> was carried out at Al-Zahraa University Hospital on 90 patients (ASA I or II) of both sexes undergoing spinal operations were randomized into three equal groups (30 patients) for each; one hour preoperatively they received oral capsules, group I; gabapentin (1200mg), group II gabapentin (800mg) and group III; placebo capsules. After induction of anesthesia with (IV) fentanyl, thiopental and cisatracurium & tracheal intubation, anesthesia was maintained by isoflurane (0.5-2%), Patients were assessed for heart rate (HR), MAP, neuromuscular blockade. Isoflurane concentration, fentanyl needed and cisatracurium consumption were recorded. <strong>Results:</strong> Experimentally: <strong>In-vitro study:</strong> Cisatracurium besylate (0.25-4µg/ml) produced dose-dependent significant reductions on the amplitude of muscle contractions. Gabapentin (6-96µg/ml) produced dose-dependent significant reductions on the amplitude of muscle contractions at 24-96 µg/mL while the first two doses 6-12 µg/mL have no effect. On interactions Gabapentin (24 µg/ml) produced synergistic effect on neuromuscular blocker effect of cisatracurium (0.25-4 µg/mL). <strong><em>In-vivo</em> study</strong> cisatracurium, IV, (1-16 mg/kg) produced no effect on both mean arterial blood pressure (MAP) and heart rate (HR) of anesthetized cats. Gabapentin (15- 240 mg/kg) caused dose-dependent significant reductions on the MAP and the HR of the anesthetized cats except the first two doses (15-30 mg/kg). On interactions Gabapentin (60 mg/kg) potantiated the effect of cisatracurium (1-16mg/kg) and caused significant reduction on mean arterial blood pressure and heart rate. <strong>Clinically:</strong> Gabapentin 1200mg produced highly significant reduction in MAP&HR at pre-induction and immediately after intubation which extended for 120min. It also prolonged the duration of neuromuscular blockade of cisatracurium 0.15 mg/kg for 100min. While Gabapentin 800mg produced significant reduction in MAP &HR at pre-induction, immediately after intubation which extended for 45min. It also prolonged the duration of neuromuscular blockade of cisatracurium 0.15mg/kg up to for70min.
<strong>Conclusion: </strong>Gabapentin has a neuromuscular blocking effect on interactions Gabapentin produced synergeistic effect on the neuromuscular blocker effect of cisatracurium. It also has considerable hypotensive as well as negative chronotropic effect. On interactions, gabapentin potantiated the effect cisatracurium on MAP&HR and caused significant decrease in MAP & HR on experimental animals and on patients undergoing elective spinal surgeries.
<strong> </strong>
Cisatracurium,Gabapantin,Isolated rat phernic-nerve,Anaesthetized cats
https://ejhm.journals.ekb.eg/article_15095.html
https://ejhm.journals.ekb.eg/article_15095_ebd8f893519d38951de83e57d8ce32b6.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
65
1
2016
10
01
Comparison of Arteriovenous Fistulae Having Blood Flow Equalto and Higher Than 800 Ml / Min as Regards Clinical and Laboratory Parameters
526
535
EN
Mona Hosny
Abdel-Salam
Internal Medicine Department , Faculty of Medicine , Ain Shams University , Cairo , Egypt
salamhosnymona2015@gmail.com
Tamer
El-Said
Internal Medicine Department , Faculty of Medicine , Ain Shams University , Cairo , Egypt
Ahmed
Abdallah
Ministry of Health , Cairo , Egypt
10.12816/0033761
<strong> </strong>
<strong>Background</strong>: According to KDOQI guidelines, the lower limit of arteriovenous fistula blood flow accounting for 600 ml / min. We have observed that this limit was not enough, at least for our patients. The aim of this work was to prove the hypothesis that this limit must be higher for performing adequate<em> dialysis</em>.
<strong>Patiemts and methods </strong>: Fifty patients on prevalent hemodialysis were included in this study. They were divided into 3 groups; group I: 12 patients formed low flow group, group II: 18 patients formed moderate flow group , and group III: 20 patients formed high flow group . Complete physical examination including clinical fistula examination for patency , were performed for all patients . Laboratory tests performed for all patients included :urea reduction ratio (URR %) , serum calcium ,serum phosphorus , calcium – phosphorus product , serum albumin , hemoglobin , serum Iron , serum ferritin ,TIBC , Transferrin saturation (TSAT %) , Kt / V (number used to quantify hemodialysis treatment adequacy), serum creatinine , together with blood urea before and after session . Fistula blood flow and static venous pressure were determined by Doppler ultrasound <strong>. </strong>Fistulogram was performed to confirm the fistula stenosis site , whenever detected by Doppler .
<strong>Results</strong>: Mineral bone profile markers , Iron profile markers , together with malnutrition – inflammation complex indicators , were all in favour of moderate and high flow groups , mainly the moderate flow group II due to the presence of much less complications than the other groups . <strong>Conclusion</strong>: We have to try to perform arteriovenous fistulae for ESRD patients needing regular dialysis , in such a way that fistula blood flow is above 800 ml / min , and it is better to be within the range of 801 – 1600 ml / min .
<strong> </strong>
<strong> </strong>
Hemodialysis – Arteriovenous Fistula,Stenosis,Doppler- Fistulogram
https://ejhm.journals.ekb.eg/article_15096.html
https://ejhm.journals.ekb.eg/article_15096_e896ed3524cbf1843e5a69e0d44c7ee0.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
65
1
2016
10
01
Efficiency of Hyaluronic Acid Binding Ability to Improve Sperm Selection in Intracytoplasmic Sperm Injection (ICSI)
536
546
EN
Amira
B.M.
Assisted Reproduction Unit, International Islamic Center for Population Studies and Research Al-Azhar University
Aziza
M.A
Assisted Reproduction Unit, International Islamic Center for Population Studies and Research Al-Azhar University
Ahmed
K.G
Assisted Reproduction Unit, International Islamic Center for Population Studies and Research Al-Azhar University
Osama
A.S.
Zoology Department, Faculty of Science, Al-Azhar University
Bakery
S.A
Zoology Department, Faculty of Science, Al-Azhar University
10.12816/0033762
Background: intra Cytoplasmic Sperm Injection (ICSI) is a reliable method for single sperm selection and injection to a large number of infertile patients. Human oocytes are naturally surrounded by cumulus cells embedded in the intracellular matrix made primarily of hyaluronic acid (HA), which plays a role as physiological selector for Intra-Cytoplasmic Sperm Injection (PICSI). Mature spermatozoa are able to bind to and digest HA for the best chance of reaching the oocyte and to maintain fertilization. The intact human spermatozoa are bound to immobilize HA surrounding oocyte <em>in vitro</em> and this leads to reduced risk of chromosomal imbalance or chromatin diseases.
Selection of spermatozoa by HA before ICSI may help to optimize the outcomes of the treatment; thus, our study aimed to compare ICSI results, based on the hyaluronic acid or traditional method for sperm selection. <strong>Setting: </strong>this study conducted at International Islamic Center for Population Studies and Research, Assisted Reproduction Unit, Al-Azhar University from January to October 2015.
<strong>Patients and Methods:</strong>120 couples with male factor infertility and normal wives conducted at the Assisted Reproduction Unit in the International Islamic Center for Population Studies and Research (IICPSR), Al-Azhar University, Egypt, during the period from January to October 2015. All cases were clinically evaluated and eligible for analysis by using inclusion and exclusion criteria. All studied men subjected to ejaculated sperm prepared by traditional method and another prepared by PICSI method. ICSI performed simultaneously for different oocytes from the same woman using an ejaculated sperm by two methods from the same husband. ICSI outcomes compared to the two sequential attempts performed, respectively. Number and quality of oocytes, fertilization rates, rate of embryo cleavage and pregnancy outcomes were recorded. The collected data were tabulated and statistically analyzed.
<strong>Results:</strong> the present study showed a significant increase in the incidence of fertilization rate, the percentage of embryos with top grade in teratozoospermia and thawed semen groups with PICSI technique compared to the traditional method of ICSI groups. Finally, the percentage of pregnancy rate an increase in all groups manipulated with PICSI technique and this increase was statistically significant.
<strong>Conclusion:</strong> this study shed more light on the physiological sperm selection method (PICSI) which may improve fertilization and pregnancy rates compared to the traditional selected sperm in ICSI. It is concluded that PICSI technique in Assisted Reproductive Technology <strong>(</strong><strong>ART) </strong>is one of the very important technique that improve fertilization in case of low fertilization rate after ICSI.
<strong> </strong>
ICSI,PICSI,Infertility,Physiological Selector,Fertilization rate,pregnancy rate
https://ejhm.journals.ekb.eg/article_15097.html
https://ejhm.journals.ekb.eg/article_15097_35c46454e80855f8eda55687f8a08640.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
65
1
2016
10
01
Amelioration of Insulin Resistance in Rats Treated with Rice Bran Oil
547
552
EN
Sohaier, A.
Abd Elbast
Zoology Department, Faculty of Science, Al-Azhar University (Girls), Cairo, Egypt
Mervat, A.
Ahmed
Zoology Department, Faculty of Science, Al-Azhar University (Girls), Cairo, Egypt
Elham, A.
Ahmed
Zoology Department, Faculty of Science, Al-Azhar University (Girls), Cairo, Egypt
Laila, A.
Rashed
Biochemistry Department, Faculty of Medicine, Cairo University, Cairo, Egypt
Mona, A.
Mohamed
Biochemistry Unit, Chemistry Department, Faculty of Science, Al-Azhar University (Girls), Cairo, Egypt
10.12816/0033763
<strong>Background: </strong>insulin resistance (IR) is a pathological condition characterized by inadequate peripheral tissue metabolic response to circulating insulin. It plays pathophysiological role in type 2 diabetes mellitus (T2DM). High dosage of fructose in the diet (60 g/100 g diet) may induce insulin resistance accompanied by deleterious metabolic consequences including hyperglycemia and hyperinsulinemia. Rice bran oil (RBO), is a rich source of antioxidants especially γ-oryzanol, α-tocopherols and tocotrienols which contribute to high oxidative stability, longer shelf life than other edible oils and high antioxidant property against free radicals. The present work was undertaken to study if the addition of rice bran oil in rat’s diets ameliorate the insulin resistance.
<strong>Materials and methods: </strong>to achieve this target, plasma fasting glucose, serum insulin and calculated HOMA-IR, which assesse the presence of insulin resistance, was evaluated. Serum lipid profile (cholesterol, triglycerides, high-density lipoprotein- cholesterol (HDL) and low-density lipoprotein- cholesterol (LDL) was also evaluated. In addition, the oxidative stress was assessed through hepatic malondialdehyd (MDA) as an oxidative biomarker and the antioxidant enzyme superoxide dismutase (SOD) was also estimated.
<strong>Results</strong>: RBO ameliorated HOMA-IR, oxidative biomarker (MDA) and increased SOD activity.
<strong>Conclusion</strong>: high fructose diet induced oxidative stress which lead to insulin resistance, this was ameliorated by addition of RBO.
<strong> </strong>
Insulin Resistance,Oxidative Stress,rice bran oil
https://ejhm.journals.ekb.eg/article_15098.html
https://ejhm.journals.ekb.eg/article_15098_5d6d9841d1be6f768ffc3ec32d1c5f2d.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
65
1
2016
10
01
Comparison of Immediate and Intermediate-Term Outcomes of Intravascular Ultrasound-Guided Versus Angiography-Guided Intervention for Type C Coronary Lesions
553
567
EN
Ahmed Essam EL-Din Mohamed
Ammar
Department of Cardiology, Faculty of Medicine, Ain Shams University
ahmed_ammar@med.asu.edu.eg
Mohamed Khairy
Abdel Dayem
Department of Cardiology, Faculty of Medicine, Ain Shams University
Nabil Mahmoud
Farag
Department of Cardiology, Faculty of Medicine, Ain Shams University
Khaled Elsayed Elarabi
Darahim
Department of Cardiology, Faculty of Medicine, Ain Shams University
Ahmed Shawky
Elserafy
Department of Cardiology, Faculty of Medicine, Ain Shams University
Haitham Galal
Mohammed
Department of Cardiology, Faculty of Medicine, Ain Shams University
10.12816/0033764
<strong>Background:</strong> the intravascular ultrasound (IVUS) is an invasive access technique that allows analysis of characteristics (qualitative and quantitative) of coronary atherosclerosis. Percutaneous coronary intervention (PCI) of complex lesions (i.e., American College of Cardiology/ American Heart Association class type C) remains challenging and the outcome may be compromised. The use of intravascular ultrasound (IVUS) to guide PCI was suggested to improve outcome.
<strong>The </strong><strong>Objectives: </strong>aim of this study wasto compare intravascular ultrasound-guided and angiography-guided Intervention for Type C coronary lesions regarding major adverse cardiac events (MACE).
<strong>Patients and Methods</strong><strong>: </strong>Our study was conducted on patients undergoing elective PCI for type C coronary lesions in Cardiology Department in Ain Shams University hospitals. The study included 50 patients who underwent IVUS guidance PCI for Type C lesions and 50 patients who underwent only angiographic guidance PCI for Type C lesions. We evaluated the impact of IVUS guidance on clinical outcomes of patients undergoing PCI for complex lesions defined as ACC/AHA type C. Major adverse cardiovascular events (MACE), a composite end-point of all-cause mortality, Q-wave myocardial infarction and target lesion revascularization, were compared between the 2 groups. Mean follow-up duration was 12 months. <strong>Results:</strong> baseline clinical characteristics were similar in both patient groups. Adding IVUS to the procedure lengthened the procedure time. On the other hand, lower amount of radiographic contrast was required in the IVUS guided group during the procedure. Regarding the target coronary vessel in our study was similar in both groups with no significant difference. In addition, the number of ostial, proximal, mid and distal lesions was similar between the two studied groups. Patients with IVUS-guided PCI underwent more direct stenting, more postdilatation, larger maximal stent diameter and greater number of implanted stents. Consequently, the final diameter stenosis was significantly better in IVUS guided group. A strategy of routine IVUS for drug-eluting stent implantation in complex coronary lesions did not improve the 1-year MACE rates.
<strong>Conclusion: </strong>use of intravascular ultrasound (IVUS) is associated with lower amount of radiographic contrast used during the procedure, more procedural time, more post dilatation and less postintervention final diameter stenosis. In addition, use of intravascular ultrasound (IVUS) in complex lesions allows proper assessment of minimal lumen area, optimizing PCI procedures and confirming stent well apposition.
<strong> </strong>
intravascular ultrasound,Major adverse cardiac events
https://ejhm.journals.ekb.eg/article_15099.html
https://ejhm.journals.ekb.eg/article_15099_cc8b663527eb15fbdd578635212d9817.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
65
1
2016
10
01
Hematological and Biochemical Changes Associated with Ectopic Pregnancy in Jazan Area Saudi Arabia
568
572
EN
Saleh M.
Abdullah
Department of Medical Laboratory Technology, Fac. Applied Medical Sciences, Jazan University
Ahmed A.
Jerrah
Department of Medical Laboratory Technology, Fac. Applied Medical Sciences, Jazan University
Ahmed F.
Elshaieb
Department of Medical Laboratory Technology, Fac. Applied Medical Sciences, Jazan University
Hala
Mowafy
Department of Obstetric and Gynecology, Fac. Medicine, Zagazig University.
10.12816/0033765
<strong>Objective:</strong> Ectopic pregnancy (EP) is an implantation of fertilized ovum outside the intrauterine cavity. Many cases of EP are not associated with a clinical signs at early stages that makes its diagnosis is difficult. The confirmation of EP needs several investigations as ultrasonography and repeated measurements of serum β-hCG levels every 48 hours that make it very expensive and take a long time so, rupture may be occurred that leads to increased maternal morbidity and mortality rates. Thus, the aim of this study was to investigate the alterations of some hematological and biochemical parameters associated with normal and ectopic pregnancy in addition to evaluate their efficacy in early diagnosis of tubal ectopic pregnancy (TEP) among women living in Jazan area, Kingdom of Saudi Arabia.
<strong>Subjects and methods: </strong>this retrospective study was carried out on 200 women with their ages ranged from 25–37 years old at the Obstetric and Gynecology Department of King Fahd Central Hospital and Sabiya General Hospital during the period between March 2010 and March 2014. The subjects were divided into three groups. Group (1) consists of 69 cases ruptured EP; Group (2) consists of 61 cases non-ruptured by visual examination during surgery and subsequently histopathological examination, where as group (3) consists of 70 women representing the control group having a normal intrauterine pregnancy<strong>. </strong>Hematological and biochemical measurements were done on all groups.
<strong>Results</strong>: the hematological findings revealed a significant increase in mean platelet volume (MPV), total leukocytic count (WBC) and erythrocyte sedimentation rate (ESR) among TEP patients especially in ruptured cases in comparison with those of normal pregnancy control<strong>. A</strong> significant decrease in hemoglobin (Hb) and packed cell volume (PCV) in TEP cases either ruptured or non-ruptured and a non-significant changes in total erythrocytic count (RBC)<strong>. </strong>The biochemical findings revealed a significant increase in serum creatine kinase ( CK) but a significant decrease in serum β-hCG in both ruptured and non-ruptured TEP.
<strong>Conclusion: </strong>it could be concluded that theWBCs,MPV count and ESR were significantly increased in TEP especially in ruptured cases. The MPV can differentiate between TEP and normal pregnancy but has less clinical significance to differentiate between ruptured and non-ruptured cases. On the other hand, the level of β-hCG is an important indicator of TEP. Moreover, serum CK cannot be used as a tool for diagnosis of TEP but may differentiate between ruptured and non-ruptured cases.
ectopic pregnancy,hematology,biochemistry
https://ejhm.journals.ekb.eg/article_15100.html
https://ejhm.journals.ekb.eg/article_15100_cba44e08643cb95de7c9941c5598f119.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
65
1
2016
10
01
Antiapototic Effect of Captopril in Cisplatin-Induced Kidney Injury in Rats
573
582
EN
Amany M.
Gad
Department of Pharmacology, National Organization for Drug Control and Research (NODCAR), Giza,
Ola M.
Abd El-Raouf
Department of Pharmacology, National Organization for Drug Control and Research (NODCAR), Giza,
Hala M.
Fawzy
Department of Pharmacology, National Organization for Drug Control and Research (NODCAR), Giza
Bahia M.
El-Sayeh
Department of Pharmacology and Toxicology,
Faculty of Pharmacy, Cairo University, Cairo, Egypt
Dalaal M.
Abdallah
Department of Pharmacology and Toxicology,
Faculty of Pharmacy, Cairo University, Cairo, Egypt
10.12816/0033767
<strong> Aim of the work: </strong>captopril protects against cisplatin induced nephrotoxicitity; however its potential modulatory effect on hemeoxygenase (HO)-1, antioxidants, as well as inflammatory and apoptotic markers has not yet been verified.
<strong>Materials and methods</strong>: male Sprague-Dawley rats were divided into control (saline), cisplatin (5 mg/kg; i.p), and captopril (60 and 100 mg/kg) given 5 days before and after cisplatin (5 mg/kg; i.p) treatment. <strong>Results:</strong>five-day pre- and post-treatment with captopril (60 and 100 mg/kg; i.p), for a total of 10 days, dose dependently, reduced blood urea nitrogen, as well as serum creatinine and gamma glutamyl transferase, but serum albumin and total protein levels were increased. Captopril restored renal pro-oxidant/antioxidant balance by activating glutathione peroxidase, catalase and superoxide dismutase, and boosting the renal glutathione content. These effects were accompanied by the reduction in serum and/or renal HO-1, tumor necrosis factor-α, monocyte chemoattractant protein-1, nitric oxide, endothelin-1 and caspase-3. Microscopically, captopril especially at 100 mg/kg dose level, prevented cisplatin-induced degenerative changes and inflammatory cell infiltration in the kidney. <strong>Conclusion:</strong> captopril protects against cisplatin nephrotoxicity by its antioxidant, anti-inflammatory and antiapoptotic potentials.
captopril,Cisplatin,renoprotection,apoptosis,Inflammation
https://ejhm.journals.ekb.eg/article_15101.html
https://ejhm.journals.ekb.eg/article_15101_1118c128c7b4f6f3c88da6c8beb00560.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
65
1
2016
10
01
Histopathological And Immunohistochemical Evaluation of Antifibrogenic Effect of Grape Seed Extract on CCl4-Induced Model of Hepatic Fibrosis
583
591
EN
Ahmed A.
Tantawy
Clinical Laboratory Sciences Department, College of Applied Medical Sciences, Aljouf University, Aljouf, KSA
aatantawi@ju.edu.sa
Abd El Ghany A.
Moustafa
Histology Department, Faculty of Medicine, Al-Azhar University, Damietta, Egypt ,aamalsanaferi@ju.edu.sa
Hussein M.
Ibrahim
Anatomy and Embryology Department, Faculty of Medicine, Ain Shams University, Egypt, hmibrahim@ju.edu.sa
10.12816/0033768
<strong>Introduction: </strong>Liver fibrosis represent a worldwide challenge of clinical importance, results from chronic damage of liver, and evidenced by build up of excessive extracellular matrix proteins.. The present study was carried out to evaluate the antifibrogenic effect of grape seed extract (GSE) against hepatic fibrosis induced by CCl4 in mice.
<strong>Experimental Design:</strong> forty adult male albino mice were divided into four equal groups; first (control) in which mice were injected IP with olive oil as vehicle. In the second group (GSE) mice were received GSE orally at a dose of 200mg/kg/day for 8 weeks while in the third group (CCl4) mice were injected IP with CCl4 (0.4ml/kg / twice weekly) for 8 weeks . In the fourth (GSE+ CCl4) group mice were injected IP with CCl4 and co-treated with GSE orally as in previous treated-groups. At the end of the experiment, animals were sacrificed and blood samples and liver tissue specimens were collected.
<strong>Results:</strong> the examined liver of CCl4-intoxicated group revealed marked hepatic fibrotic lesions confirmed by Masson’s trichrome stain and associated with the presence of intensely stained α -SMA-positive hepatic stellate cells (HSCs) in entire of the hepatic lobules and in the vicinity of bridging fibrotic septa. Hepatic degeneration and necrosis were also seen. This hepatic damage was associated with significant increases in AST and ALT activities with low albumin levels and hypoproteinemia. Co-administration of GSE with CCl4 improved the microscopic picture of liver where scanty fibrotic lesions and mild degeneration of some hepatic cells were recorded. Less intensely stain
ed α -SMA-immunopositive cells were observed. Serum AST , ALT, albumin and total protein values were more or less within the ranges of these parameters in the control non-intoxicated group.
<strong>Conclusion: </strong>GSE has potent antifibrogenic effect on CCl4-induced hepatic fibrosis by inhibiting HSCs activation, decreasing collagen synthesis and improving hepatic regenerative capability through its powerful antioxidant and anti-inflammatory properties.
<strong> </strong>
Liver fibrosis,Grape seed extract,histopathology,Immunohistochemistry,serum Biochemical analysis
https://ejhm.journals.ekb.eg/article_15104.html
https://ejhm.journals.ekb.eg/article_15104_b5864b00dc7ff4ae9b5ee2cc9da6f6a5.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
65
1
2016
10
01
Natural Killer Cells And Their Interaction With Dendritic Cells in Hepatitis C Infection
592
597
EN
Aisha Yassin
Abdel Ghaffar
Clinical pathology department-Faculty of medicine - Ain shams University
Manal Zaghloul
Mahran
Clinical pathology department-Faculty of medicine - Ain shams University
Hossam Mostafa
Fahmy
Clinical pathology department-Faculty of medicine - Ain shams University
Dina Elsayed
Elshennawy
Clinical pathology department-Faculty of medicine - Ain shams University
Dalia Youssef
Samaha
Clinical pathology department-Faculty of medicine - Ain shams University
Sara Ibrahim abdel Fattah
Taha
Clinical pathology department-Faculty of medicine - Ain shams University
10.12816/0033769
<strong>Background</strong>: Hepatitis C is a viral infection of the liver that has affected around 200 million people globally. The immune response against HCV infection includes both the innate and adaptive arms of immunity, with crosstalk between liver inhabitant and infiltrating cells. In the current study, we aimed to investigate the natural killer cells activation and inhibition status, and their role in interaction with DCs utilizing different combinations between NK cells and DCs in the presence of HCV peptides in a ratio of 5 NK: 1DC.<strong>Results</strong>: HCV NK cells upregulated both activation and inhibition markers. This could be attributed to HCV infection and their interaction with DCs especially healthy DCs. Moreover, apoptosis of DCs and NK cells occurred more in HCV NK cultures due to their higher frequency of NKp30 and KLRG1. The death of NK cells was more than DCs despite DCs maturation defect due to HCV infection, suggesting that the inhibitory marker KLRG1 took the upper hand over the upregulated activation markers leading to impaired cytotoxic activity and apoptosis of NK cells.
<strong>Conclusion</strong>: The bidirectional crosstalk between NK cells and DCs is important in both potentiating mechanisms of the innate immune responses and the subsequent adaptive immune responses in the immune surveillance of cancer and infections. HCV infection impairs this crosstalk which may be a leading cause in viral persistence and chronicity.
<strong> </strong>
natural killer cells and dendritic cells crosstalk,natural killer cells and dendritic cells in HCV,natural killer cells and dendritic cells co-culture
https://ejhm.journals.ekb.eg/article_15106.html
https://ejhm.journals.ekb.eg/article_15106_b06d1360235e6256b5c42a8bb38831f0.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
65
1
2016
10
01
Seasonal Variation of Biochemical Composition of Penaeus Semisulcatus (Decapoda: Penaeidae) and the Effect of Its Shell Extract on Bacteria, Fungi and Cancer
598
610
EN
Amr. M.
Nasef
Marine Biology Section, Zoology Department, Faculty of Science, Al-Azhar University
dramrnasef@yahoo.com
10.12816/0033770
<strong>Background: </strong>shrimps are extremely good source of high nutritive value making them a very healthy choice for human food. <strong>Aim of the work:</strong> to examine the changes induced by seasonal variation in <em>Peanuts semisulcatus</em>biochemical composition and nutritive value. The present work aimed also to screening of crude shell extract for bioactivity and economic importance. <strong>Materials and methods</strong>: The proximate composition and biochemical constituents were analyzed seasonally in the muscle tissue of <em>Penaeus semisulcatus. </em>The Crude protein, lipid, carbohydrate, calorific value, moisture and ash were quantified in the Penaeid Prawn. Extraction, isolation, and identification of some bioactive marine natural products were done for study its effect on bacteria, fungi and Larynx cancer. <strong>Results</strong>: there is seasonal variation of the nutritional status of edible Portion of prawn. Statistical analysis for the measured results of the correlation values for each of measurements with the seasons of the year. The correlation was a positive weak. The results of Antimicrobial activity of<em> Penaeus semisulcatus</em> shell extract indicated a significant effect differences between the groups treated with shell extract (1.5, 2.5, and 5 mg/mL) compared to the control group. Also, evaluation of viability of Hep -2 cell line post treatment with shell extract of<em>Penaeus semisulcatus</em> using Sufranin uptake assay as (M T T) uptake and Microscopic examination indicated a significant difference between the groups treated with shell extract compared to the control group. Cell viability decreased depending on dose or concentration. The shell extract inhibited the proliferation of a Larynx cancer cell line in a dose dependent manner.
<strong>Conclusion</strong>: the results of the present study reported that, the nutritional values of shrimp muscle constituents were different from season to the other, with positive weak correlation. Also, Shell extract can be used as antibacterial, antifungal and anticancer.
Seasonal variation,edible Portion,proximate composition,seafood – Marine biotechnology- Marine ecology,Biochemical composition,Penaeus semisulcatus,Decapoda –Benthos,shell,extract – Bacteria- Fungi – Cancer
https://ejhm.journals.ekb.eg/article_15118.html
https://ejhm.journals.ekb.eg/article_15118_7d351fdf4404d46e6d504b4770677025.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
65
1
2016
10
01
The Protective Effect of Olive leaves Extract or Bone Marrow Mesenchymal Stem Cells on Skin Tissue Damage Induced in Gamma Irradiated Rats
611
626
EN
Nahed Mohamed Mansour
Emam
Faculty of Sciences, Al- Arish University, Egypt
mansour.nahed@yahoo.com
Khadija Abdul jalil
Fadladdeen
Faculty of Science, University of King Abdel-Aziz University, Saudi Arabia
10.12816/0033773
<strong>Aim of the work</strong>: this study aimed to examine the histological and histochemical changes in the skin tissue of male rats after exposure to gamma radiation and the possible therapeutic effect of either olive leaf extract or bone marrow mesenchymal stem cells.
<strong>Material and methods: </strong>the present study was applied on forty adult male albino rats (<em>Sprague Dawely</em> strain). The rats were categorized equally into five groups (1-C group: control rats; 2- O group: rats treated with plant leaves extract (15 mg/kg b. wt. /daily); 3-R group: rats exposed to a single dose of gamma-radiation (3 Gy); 4-RO group: rats of this group treated with olive leaf extract 15 mg /kg b.wt./daily one week prior to irradiation and one week post irradiation; 5- RS group: rats of this group were irradiated with 3Gy then treated with bone marrow mesenchymal stem cells (3×10<sup>6</sup> cells / ml suspension) through the caudal vein about 5 hours post radiation exposure. Histopathological and some common histochemical changes were studied.
<strong>Results</strong>: rats exposed to gamma radiation showed several histological and histochemical changes, these changes were improved by using either olive extract or bone marrow mesenchymal stem cells. The bone marrow mesenchymal stem cells (BMSCs) showed more obvious curative effect than olive leaf extract.
<strong>Conclusion: </strong>the present work showed that both olive leaf extract and bone marrow mesenchymal stem cells have skin tissue radiotherapeutic effects against gamma radiation in male albino rats.
<strong> </strong>
γ-radiation,albino rats,skin,bone marrow mesenchymal stem cells (BMSCs)–Histopathology- Histochemistry
https://ejhm.journals.ekb.eg/article_15119.html
https://ejhm.journals.ekb.eg/article_15119_17fbb254522c7d52f078b9d572ca68b5.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
65
1
2016
10
01
Sex Hormone-Binding Globulin in Obese Type 2 Diabetics
627
633
EN
Eman M
Abd EL Salam
Internal Medicine Departments, Faculty of medicine, Al Azhar University, Cairo, Egypt
Nagwa A
Mohamed
Department of Clinical and Chemical Pathology, National Research Center, Cairo, Egypt
Hend M
Maghraby
Internal Medicine Departments, Faculty of medicine, Al Azhar University, Cairo, Egypt.
Rehab A
Mohamed
Internal Medicine Departments, Faculty of medicine, Al Azhar University, Cairo, Egypt.
10.12816/0033774
<strong>Background:</strong> Obesity is one of risk factors for type 2 diabetes because of its association with insulin resistance and poor glycemic control. Sex hormone–binding globulin (SHBG) and adipose tissue hormones have a role in development of insulin resistance, hyperlipidemia and type 2 diabetes. Serum SHBG has a role in glucose homeostasis and low levels are associated with development of diabetes, cardiovascular diseases, insulin resistance and hyperinsulinemia. <strong>Aim of work: t</strong>o study the relationship between serum SHBG, obesity, and metabolic parameters in type 2 diabetes in both sex.
<strong>Patients and Methods</strong>: forty obese type 2 diabetic patients and ten obese non-diabetic as controls were included in this study. Blood was taking from all subjects for estimation of glucose, Lipid profile, insulin and SHBG. <strong>Results: </strong>there was highly significant decrease in mean serum SHBG concentration in diabetic group compared with control non diabetic group. There were significant negative associations between serum SHBG and age, disease duration, BMI and glucose. On the other hand, there were non significant correlations between SHBG and waist circumference, fasting insulin, HOMA-IR, cholesterol and triglyceride levels.
<strong>Conclusion:</strong> Low serum SHBG is associated with hyperglycemia in both sexes, independent of insulinemia
<strong> </strong>
SHBG,Type 2 Diabetes,Insulin,Obesity
https://ejhm.journals.ekb.eg/article_15120.html
https://ejhm.journals.ekb.eg/article_15120_cf9223ae062b7778dec8945de86f0926.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
65
1
2016
10
01
The Fibrinogen/CRP Ratio as a New Parameter for the Prediction of Disseminated Intravascular Coagulation in Patients with HELLP Syndrome
634
642
EN
Tarek Fathy
Tamara
Faculty of Medicine – Ain-Shams University
Ihab Fouad
Serag
Faculty of Medicine – Ain-Shams University
Tamer El-Sayed Mohamed
El-Ghazaly
Faculty of Medicine – Ain-Shams University
Mohammed Adel Ali
Ahmed
Faculty of Medicine – Ain-Shams University
10.12816/0033775
<strong>Background: </strong>The syndrome of Hemolysis, elevated Liver enzymes, and Low Platelet count (HELLP) is a life-threatening variant of preeclampsia, and may be accompanied by disseminated intravascular coagulation (DIC). Recently the fibrinogen/C-reactive protein (CRP) ratio has been suggested as a measurement that predicts onset of DIC. The authors sought to analyze the fibrinogen/CRP ratio among obstetric patients who developed DIC due to HELLP syndrome. <strong>Aim: </strong>the aim of this study is to determine if the fibrinogen/C-reactive protein (CRP) ratio could be used as a predictor for disseminated intravascular coagulation in obstetrics patients with the HELLP syndrome. <strong>Patients and Methods: </strong>this study was conducted as a prospective observational study at Ain Shams Maternity Hospital from November 2014 to November 2016 .The study included Patients diagnosed to have Severe Pre Eclamptic Toxemia SPET according to <strong><em>ACOG (2013).</em></strong>Patients was diagnosed with the HELLP syndrome according to the <strong>Martin</strong> classification of HELLP syndrome. <strong>Results: </strong>the results of our study suggest that replacing the use of fibrinogen levels alone with the fibrinogen/CRP ratio would enhance the diagnostic and prognostic power for DIC in patients with HELLP syndrome. <strong>Conclusion: </strong>in light of the physiologic changes of the coagulation cascade during gestation, the International Society on Thrombosis and Hemostasis <strong>ISTH</strong> score could not be implemented in pregnant women alone for the diagnosis and prediction of DIC. <strong>Recommendations: </strong>further evaluation of the fibrinogen/ CRP ratio is required to determine the generalizability of this marker’s use in DIC because of causes such as placental abruption, septic abortion, and failed abortion. Furthermore, prospective studies should be performed to determine the best method to predict if there any new method to predict DIC in patients with the HEELP syndrome.
<strong> </strong>
HELLP syndrome,Fibrinogen,C-reactive protein,Pre-eclampsia,DIC
https://ejhm.journals.ekb.eg/article_15121.html
https://ejhm.journals.ekb.eg/article_15121_a6848837a88247f281b2a6888f2cee0d.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
65
1
2016
10
01
Risk of Osteoporosis and Osteopenia in Patients with Prolonged Use of Proton Pump Inhibitors
643
647
EN
Abdullah Ali
Al-Zahrany
Department of Orthopedics, Taif University, Saudi Arabia
abdullazahrani@yahoo.com
Majed
AL Mourgi
Department of Thoracic Surgery, Taif University, Saudi Arabia
10.12816/0033776
<strong>Background and aim of the work:</strong> several studies suggest that proton pump inhibitors (PPIs) use may be involved in development and acceleration of osteoporosis. The aim of this study is to investigate the relationships between prolonged uses of PPIs in patients with gastro-esophageal reflux disease (GERD) and to reveal their possible role in development of osteopenia or osteoporosis with evaluation of different diagnostic tools which help in follow up of those patients.
<strong>Patient and methods: </strong>This prospective controlled study which was conducted at King Abdul Aziz Specialist Hospital in Taif, Saudi Arabia, from January 2013 to June 2016. We compared the prevalence of osteoporosis or osteopenia in 2 groups of individuals, the first group; of 30 patients using PPIs as treatment of GERD for more than 2 years. The second group included thirty healthy control subjects .In both groups we measured the bone mineral density using the dual energy X-ray absorptiometry (DEXA), calcium (Ca), inorganic phosphorus (P), serum alkaline phosphatase, and deoxypyridinoline (DPD) in urine.<strong> Results: </strong>there were no significant differences between the 2 groups as regards, age, gender, and their clinical history (P > 0.05), however, the history of fragility fracture was significantly higher in PPIs group of patients (P< 0.05). The means of antroposterior spine and left femur BMD-T scores were lower than normal in both groups; however, it was significantly lower in PPIs group than in control group (P< 0.05). Serum calcium was slightly lower than the reference range with normal phosphorus level without significant difference between both groups (P> 0.05). The serum alkaline phosphatase and urinary DPD were higher than normal reference levels, but, significantly higher in patients receiving PPIs (P< 0.05). The number of osteopenic/osteoporotic patients was significantly higher in PPIs group than in control group (P< 0.05). Osteopenia and osteoporosis were significantly correlated in PPIs group with male gender, younger age group of patients (P< 0.05), and the correlation was highly significant with the duration of use of the drug (P<0.001). In control group the decrease in bone density was significantly correlated with the female gender and to older group of patients (P< 0.05).
<strong>Conclusion: </strong>in GERD patient using PPIs, the osteopenic/osteoporotic effect with increased possibility of fragility fractures must be discussed with the patient if prolonged use of these drugs is expected, taking in consideration the potential safety and reliability of laparoscopic or thoracoscopic surgical options as alternative therapy.
<strong> </strong>
<strong> </strong>
GERD,PPIs,Osteopenia,Osteoporosis,Fragility fractures
https://ejhm.journals.ekb.eg/article_15122.html
https://ejhm.journals.ekb.eg/article_15122_cbae9215e3f2e06c414b25cb1e98214a.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
65
1
2016
10
01
The Effectiveness of Three Layers Foam Dressing as an Offloading Technique in Treating Diabetic Foot Ulcer – Comparative Study
648
651
EN
Amal Safar
Al Thebati
King Faisal Hospital
Nora Mohammed
AL-Ouda
Taif, Prince Sultan Military Medical City
Sahar Masri
Al khaldi
King Faisal Hospital
Asmaa Doghether
Al sofyani
Ministry of Health, Taif
Mohamed
Al Saeed
Department of surgery, Taif University
10.12816/0033777
<strong>Background and aim of the work</strong>: and aim of the work: More than 25% of Saudi Arabia population are diabetics, about 20% of the will develop ulcer in their feet. Offloading is the cornerstone in prevention or healing of plantar neuropathic foot ulcers. This study aimed to investigate the effectiveness of use of three layers elastic foam as an off-loading modality in patients with diabetic non infected neuropathic ulcers in term of the speed of healing progress and comparing that with removable walking boat off-loading techniques.
<strong>Patients and methods:</strong> this prospective double-blind, randomized, controlled clinical trialwas done in diabetic foot care clinics at King Abdul Aziz specialist Hospital, King Faisal general Hospital and Prince Mansour military Hospital, Taif, Saudi Arabia from January 2014 to October 2016.Diabetic patients with non infected neuropathic plantar ulcers after debridement of at least 2 weeks were included in the study. Ischemic ulcers are excluded from the study. Patients who met the inclusion criteria of this study weresubdevided randomized into 2 groups, the felted foam dressings group; in which the three layers felted foam was applied around the ulcer. Control group the removable walking boat was used. In both groups the ulcer was covered with saline soaked dressing to be changed daily.
<strong>Results:</strong>47 patients were enrolled in the study (23 in felted foam group and 24 in the removable walking boat group). There was no significant difference in the demographics, ulcer size, duration of diabetes, and clinical and laboratory data between both groups (P > 0.05). The mean duration of complete healing of the ulcer was highly significantly shorter in felted foam group than in the removable walking boat group (P < 0.001). In both groups the duration of healing was negatively correlated with the patient age, the level of HbA1c,andthe ulcer size (P < 0.05).
<strong>Conclusions</strong>: the three layers felted foam is effective, simple, and less expensive offloading technique and it superior to removable walking boat in promoting the complete healing of neuropathic diabetic foot ulcers.
<strong> </strong>
neuropathic plantar ulcer,three layer felted foam,removable walking boat
https://ejhm.journals.ekb.eg/article_15123.html
https://ejhm.journals.ekb.eg/article_15123_856a3aefb77e760adce7a94ac6ae1f13.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
65
1
2016
10
01
Prevalence of Generalized Anxiety Disorder in Patients with Rheumatoid Arthritis and its Relationship with Disease Activity
652
661
EN
Asmaa B
Ahmed
Physical Medicine, Rheumatology and Rehabilitation Department
Abdulah MA
Radwan
Physical Medicine, Rheumatology and Rehabilitation Department
Hameed M
Baddary
psychiatry, Head of Neuropsychiatry Department,Faculty of Medicine, Sohag University
10.12816/0033778
Background: rheumatoid arthritis (RA) is a lifelong disease with a progressive disabling course and individuals with RA experience higher levels of psychological distress than general population. Objective: the objective of the present study was to assess the prevalence of generalized anxiety disorder (GAD) in RA patients and determine its relationship with disease activity.
Patients and Methods: the study included 200 RA cases. Psychiatry examinations of all cases were performed according to Hamilton scale. Patients who suspected to have GAD were further assessed by the most recent diagnostic criteria for GAD in diagnostic and statistical manual of mental disorders fifth edition (DSM-5) and psychiatry assessment sheet (PAS).
Results: the prevalence of GAD in RA cases was 38.5% (n=77) assessed by psychiatry assessment sheet (PAS). RA patients with GAD significantly showed higher disease activity measures than those without GAD (P value <0.001). It was found that GAD did not related to disease duration (r=0.617; p value >0.05) or RF positivity (r=0.058; p value >0.05). Conclusion: generalized anxiety disorder (GAD) is common to occur in RA cases. Disease activity was significantly higher in RA cases with GAD than RA cases without GAD. GAD was found to be not related to disease duration.
Rheumatoid Arthritis,generalized anxiety disorder
https://ejhm.journals.ekb.eg/article_15129.html
https://ejhm.journals.ekb.eg/article_15129_2abc1c5f87c964c23a49fc29d8ddc3cc.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
65
1
2016
10
01
Determinant Analysis of Obesity among Adult Females in Egypt
662
669
EN
Raouf
Alebshehy
Department of Preventive Medicine, Ministry of Health, Egypt
dr.ebsh@yahoo.com
Nura Musa
Shuaib
TB and Leprosy, Ministry of Health, Nigeria
Jato Denis
Mbako
Integrated Health for All Foundation, Cameroon
Dina
Barffo
Ghana Health Service, Ghana
Roland Kuuzagr
Nuotol
Kintampo College of Health, Ministry of Health, Ghana
10.12816/0033779
<strong>Background: </strong>obesity is a major and growing health problem that affects developed, and developing countries. It has many health, financial, and social consequences. Therefore, addressing obesity tops the World Health Organization’s public health agenda. In Egypt, there is a remarkable increase in obesity with more than one third of the whole population being obese. A particular issue in Egypt is that prevalence of obesity is more than double among females (46%) as compared to males (22%). Moreover, there is no national program to address the problem, and 95% of females are not taking any measures to change their weight. Despite the major gender gap in obesity prevalence, little research has examined gender differences in its determinants. Therefore, this study aims to analyse determinants of adult Egyptian female obesity.
<strong>Methods:</strong> this study is an in-depth review based on secondary data collection. A conceptual framework was developed to analyse the determinants. Data is obtained from different resources such as key health databases such as PubMed, Global health, and websites of relevant institutions such as World Health Organization, and Egypt’s Ministry of Health. <strong>Findings</strong>: the study has revealed the huge burden of obesity among women in Egypt. It shows that obesity among Egyptian females increases with age, wealth, urban residency, unhealthy diet, and physical inactivity. It revealed the growing trend of obesity among poor and rural people. It also discussed other sectors of influence that lead to higher obesity rates such as urbanization, and levels of education.
<strong> </strong>
Obesity,Female,Egypt
https://ejhm.journals.ekb.eg/article_15130.html
https://ejhm.journals.ekb.eg/article_15130_f8ca7fe4b485ea17afaeeff8ac4619bc.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
65
1
2016
10
01
Threats to Egypt’s Plan to Eliminate Hepatitis C Virus Infection: Injection Drug Users and Sex Workers are Unaddressed Reservoir That Cannot Be Ignored; A Short Communication
670
671
EN
Raouf
Alebshehy
Egyptian Ministry of Health
dr.ebsh@yahoo.com
10.12816/0033780
<strong>Background:</strong> Hepatitis C virus (HCV) is a huge health problem in Egypt with 15% prevalence, 165,000 annual new cases, and 40,000 annual deaths. Egypt has developed a five years plan to eliminate HCV, however this plan does not fully address the problem of HCV among vulnerable groups such as injection drug users and sex workers. This article is to shed the light on this unaddressed reservoir that threatens the fully elimination of HCV in Egypt. It also provides an overview about proposed strategies to tackle HCV problem among that sensitive population.
<strong> </strong>
hepatitis C,injection drug users,sex workers,peer health education
https://ejhm.journals.ekb.eg/article_15131.html
https://ejhm.journals.ekb.eg/article_15131_a5892dd653f0cf449a7349d5e1826090.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
65
1
2016
10
01
Relationship between Warfarin and Thrompocytosis (A Case Report Study)
672
673
EN
Ghormmallah
Al-Ghamdi
Cardiology department Internal Medicine department
Hamdan
Al-Ghamdi
Critical Care unit Internal Medicine department
Mansour
AL-Ghamdi
Pediatric department Internal Medicine department
Shog Hamoud
Al-Otibi
Taif Children Hospital, Taif, Saudi Arabia
10.12816/0033781
This report is point to patient admitted to our hospital as case of G6PD and dilated cardiomyopathy, with congestive heart failure started on anti-failure and aspirin and need to be admitted on ICU for inotropic support, then on the 2<sup>nd</sup> day the patient developed thrombocytopenia then we stopped aspirin and warfarin started after using of warfarin by one-day patient developed sever thrombocytosis so we consider to start low molecular heparin which improved the platelets count then started to decreased to normal range in 5 days duration after LMH started.
<strong> </strong>
Warfarin,Thrompocytosis
https://ejhm.journals.ekb.eg/article_15132.html
https://ejhm.journals.ekb.eg/article_15132_c857a32727e2dadb77b7bfb0e19f3822.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
65
1
2016
10
01
Perception of Knowledge, Attitude, Practice of Safety, Effectiveness, Consequences and Management of Bariatric Surgery among Community in Jeddah City
674
682
EN
Ayman Sayed
Abouhamda
Department of General Suergery, King Abdulaziz University Hospital, Saudi Arabia
Yousef Ehab
Gan
Department of General Suergery, King Abdulaziz University Hospital, Saudi Arabia
Fahad Mohammed
Altowairqi
Department of General Suergery, King Abdulaziz University Hospital, Saudi Arabia
RadwanYousef
Badr
Department of General Suergery, King Abdulaziz University Hospital, Saudi Arabia
Abdulghani Abdulaziz
Alzamzami
Department of General Suergery, King Abdulaziz University Hospital, Saudi Arabia
Khalid Ahmed
Sherian
Department of General Suergery, King Abdulaziz University Hospital, Saudi Arabia
Feher Mohammed
Alturkistani
Department of General Suergery, King Abdulaziz University Hospital, Saudi Arabia
Mohannad Talal
Tolah
Department of General Suergery, King Abdulaziz University Hospital, Saudi Arabia
Abdulrahman Ghazi
Alqurashi
Department of General Suergery, King Abdulaziz University Hospital, Saudi Arabia
Wail Omar
AlGorashi
Department of General Suergery, King Abdulaziz University Hospital, Saudi Arabia
Sultanah Sameer
Saeedi
Department of General Suergery, King Abdulaziz University Hospital, Saudi Arabia
Marwa Thani
Hawsawi
Department of General Suergery, King Abdulaziz University Hospital, Saudi Arabia
Zina Abdulkareem
Al Zahidy
Department of General Suergery, King Abdulaziz University Hospital, Saudi Arabia
10.12816/0033782
<strong>Background:</strong> obesity is associated with increased mortality and morbidity. The use of bariatric surgery has recently increased dramatically in order to lose weight fast; however, the heavy consequences and the long-term weight loss induced by bariatric surgery has favorable effects on life span remains unclear.<strong> Aim of Study:</strong> this study was aimed to explore knowledge and beliefs about safety, effectiveness and consequences of bariatric surgeries among community population in Jeddah city and to evaluate the role of demographic factors in shaping those beliefs, and assess possible associations between demographic characteristics with lose weight preventive behavior.
<strong>Patients and methods:</strong> this study was done in 2016 and carried out among a sample of 474 citizens, of them 70.1% women and 29.9% men. The mean age of citizens was 35.77. To assess citizens’ demographic factors, risk factors of obesity and beliefs about bariatric surgeries, consenting citizens responded to an anonymous online questionnaire. The data was entered and analyzed using SPSS version 20. Data were entered into the Statistical Package for Social Sciences (SPSS, version 20) and descriptive analysis conducted.
<strong>Results</strong>: the results of the current study show that among the respondents, (24.5%) were obese, (13.7%) severely obese and (9.3%) were morbid obese. The majority of them believed that the lack of exercise is the cause of their obesity (45.7%), (71% ) of the respondents think that genetics play a role in obesity, (69.3%) of respondents have someone in their family who suffers from obesity and (61.6%) were not keen to exercise. The majority of respondents (77.4%) think that weight loss procedures contribute to weight loss, however (69.8%) are not of favor towards weight loss procedures to get rid of obesity, (63.4%) of them have not undergone any surgery, and (86.6%) of the respondents do not think of surgeries as their first choice to lose weight without exercise or diet, also (71.0%) think that weight loss procedures and its complications may lead to death.The majority of the respondents (74%) have inadequate beliefs about bariatric surgery and (50.8%) of the respondents have good knowledge on prevention behavior of obesity.
<strong> </strong>
<strong><br clear="all" /> </strong>
Bariatric surgery,Obesity prevention,weight loss
https://ejhm.journals.ekb.eg/article_15133.html
https://ejhm.journals.ekb.eg/article_15133_93b5a237521b938f01e56ea226709902.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
65
1
2016
10
01
The Potential Anticancer Action of Lectin Extracted from Pisum sativum Against Human Hepatocellular Carcinoma Cell Lines
683
692
EN
Hafez
E.E
Genetic Engineering Department, New Borg El-Arab City, Alexandria, Egypt
Shati
A.A
Biology department, Science College, King Khalid University, Abha, Saudi Arabia
aaalshati@kku.edu.sa
10.12816/0033783
<strong>Blackgrond:</strong>plant lectins, carbohydrate binding proteins, are distributed in many species of medicinal plants mainly those belong to <em>legumonase</em> family. This study aimed to investigate the anticancer activity of the lectin extracted from <em>Pisum sativum</em> on Human Hepatocellular carcinoma (HepG2). <strong>Materials and Methods</strong>:the morphological signs of apoptosis were examined and the ability of lectin to induce alteration in both pro-apoptotic and anti-apoptotic such as Bax, IκBα, P53 and Bcl2 genes were analyzed using RT-QPCR method. The safety usage pattern of <em>P. sativum</em> lectin was evaluated on human HepG2 cell lines. Results: lectin displayed high antioxidant activity on the Hep2 cells when compared with 5FU (anti-cancer drug as a control). Lectin dilution that exhibits LC50 on HepG2 cells was found to touch 25% from the original concentration (100%). The extracted lectin was found with inhibition percentage in cellular viability touching 80.5% with 67.6% inhibits the integration of BrdU in the HepG2 proliferated cells. HepG2 treated cells showed apparent nuclear condensation after 16 h of treatment as lectin had the ability to upregulate the gene expression of P53 and IκBα and down regulates Bax and Bcl2. Conclusion: lectin may have a vigorous role in achievement of hepatocarcinoma therapy plan.
<strong> </strong>
Lectin,Hepatocarcinoma,real time PCR,antioxidants,Anticancer activity
https://ejhm.journals.ekb.eg/article_15134.html
https://ejhm.journals.ekb.eg/article_15134_b31d5c6a186b329687f97b41d5cf3a3f.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
65
1
2016
10
01
Assessing the Knowledge, Attitudes and Practice of Diabetic Complications among Physicians in Taif Saudi Arabia
693
695
EN
Marah Mohammed
Alzaidi
College of Medicine
dr.mara7-alzaidi@hotmail.com
Haifa saeed
Almalki
College of Medicine
Ghada Mohammed
Alghamdi
College of Medicine
Hala
El Nashar
Department of Pathology, Taif University, Saudi Arabia
10.12816/0033784
<strong>Background and aim of the work: </strong>The aim of this study is to assess the Knowledge, Attitude, and Practices (KAP) towards diabetes and its complications among physicians in Taif.
<strong>Subjects and Methods:</strong> this survey was done by interviewing the physicians to fill the questionnaire focusing on their awareness about screening, diagnosis, and preventive measures of diabetic complications.
<strong>Results:</strong> A total of 101 physicians (72% females), 88% of them were practicing in urban areas and 78% of them practiced > 5 years. 90% of the physicians had postgraduate qualifications and 49% of them had special training on diabetes management. Eighty one percent follow guidelines for care for diabetes. In 72% of practioners diabetic patients constituted 18-50% of patients in their daily practice and in 28% of practioners diabetic patient were > 50% of daily practice. Over 80% of the participants were aware about the correct answers. Comparing the percentages of awareness among practioners in tertiary hospitals and primary health care centers it was significantly higher in the formers (P< 0.05). The question which had the highest percentages of correct answer was about the value of periodic examination of diabetic patient (correct in94%) The effect of lipid profile on diabetic complications was the least to be answered correctly.
<strong>Conclusion:</strong> The study revealed a good to excellent awareness of Taif practioners about early detection, diagnosis and management of diabetic complications especially those practicing in tertiary hospitals, reflecting the values of continuous medical education programs applied in such hospitals.
<strong> </strong>
Taif physicians,diabetic complications,KAP
https://ejhm.journals.ekb.eg/article_15135.html
https://ejhm.journals.ekb.eg/article_15135_f012cedec42e2d16260f3e29bc64ce7a.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
65
1
2016
10
01
Impact of Sleeve Gastrectomy on Weight Loss, Comorbidities of Obesity, and Quality of Life in Saudi Arabia
696
698
EN
Mohammad E.
Mahfouz
Taif University College of Medicine, Saudi Arabia
Abdulrahman
Altowairqi
Taif University College of Medicine, Saudi Arabia
Haitham
Altowairqi
Taif University College of Medicine, Saudi Arabia
Saif
Altalhi
Taif University College of Medicine, Saudi Arabia
Fahad
Alotaibi
Taif University College of Medicine, Saudi Arabia
Fahad
Alhazmi
Taif University College of Medicine, Saudi Arabia
Abdulmajeed
Muteb
Taif University College of Medicine, Saudi Arabia
Maha
Aljumaie
Taif University College of Medicine, Saudi Arabia
Hala
El Nashar
Taif University College of Medicine, Saudi Arabia
10.12816/0033785
<strong>Background and aim of the work: </strong>laparoscopic sleeve gastrectomy (LSG) proved to be an effective operation for control of obesity and associated comorbidities. The aim of this study was to evaluate the impact of this operation on weight reduction, improvement of obesity comorbid diseases, and the quality of life (QoL).<strong>Patients and method:</strong> A cross sectional web-based survey was conducted between June and October 2016. A total of 660 patients who was subjected to LSG volunteered in the survey and answered the online questionnaire which consisted of 30 items (multiple choice and short answered questions). <strong>Results:</strong> the study involved 425male patients (64.4%) and 235 female patients (35.6%). The mean preoperative BMI was significantly reduced from 38.6±9.1 kg/m<sup>2</sup> to 28.4±6.9kg/m<sup>2 </sup>after a mean duration of 24±5.6 months following LSG. There was highly significant improvement (P< 0.001) in obesity comorbid diseases; however, the improvement was significant (P< 0.05) for improvement in sexual performance. The patient satisfaction from the weight reduction after LSG was rated as excellent by 68.2% of participants, as very good to good by 24.2% of participants, and as just accepted by 1.8%. 5.8% of patients had no changes or even gain weight after LSA (P>0.05). 92.4% considered that their quality of life became better and would recommend the sleeve gastrectomy for other obese people who suffer from the obesity.
<strong>Conclusion: </strong>laparoscopic sleeve gastrectomy is a good option for those with morbid obese patients as regard weight reduction, improvement of obesity comorbid diseases, and their quality of life.
<strong> </strong>
sleeve gastrectomy,obesity comorbid diseases,quality of life,Saudi patients
https://ejhm.journals.ekb.eg/article_15136.html
https://ejhm.journals.ekb.eg/article_15136_eee1f958f550494cf1f4a08da2f49cc6.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
65
1
2016
10
01
Histological Effect of Bisphosphonate, Vitamin D and Olive Oil on Glucocorticoid Induced Osteoporosis (Gio) in Albino Rat
699
708
EN
Mohammad Ahmad
Kasem
Histology department at Al-Azhar Faculty of Medicine in Assiut
Ahmad Mohammad
Abdel-Aleem
Histology department at Al-Azhar Faculty of Medicine in Assiut
Abdallah Shehatah
Said
Histology department at Al-Azhar Faculty of Medicine in Assiut
El-Sayed Galal
Khedr
Histology department at Al-Azhar Faculty of Medicine in Cairo
10.12816/0033786
<strong>Background:</strong> Previous studies demonstrated that the prevalence of osteoporosis was 4% in women aged 50 to 59 years compared to 44% in women aged 80 years and older. Osteoporosis may be primary or secondary. Glucocorticoid induced osteoporosis (GIO) is considered among the most common causes of secondary osteoporosis. The present study aimed to assess if vitamin D and olive oil could be useful in the treatment of GIO as bisphosphonate.
<strong> Materials and Methods:</strong> Fifty adult female albino rats weighing 180-220 grams and aged 16-19 weeks were divided into five groups (each consists of ten rats): the control group, osteoporotic group, bisphosphonate group, vitamin D group and olive oil group. The first group served as a negative control group. The other four groups were injected subcutaneously by methyl-prednisolone (0.5 mg/kg/day - three times a week) for 60 days to induce osteoporosis (glucocorticoid induced osteoporosis “GIO”). One of the four groups served as a positive control group while other three groups were treated with oral bisphosphonate (0.84 mg/kg/day - five days a week), oral Vitamin D<sub>3</sub> (0.1 ug/kg/day - five days a week) and oral Olive oil (0.1 ug/kg/day - five times a week) respectively for additional 60 days. At the end of the experiment, the right femur was removed from each rat and examined histologically after staining by hematoxylin and eosin stain as well as Masson's trichrome stain. The stained sections were photographed and analyzed to assess cortical bone thickness, osteocyte number and osteocyte lacunae. Results: By comparing the cortical thickness in all groups we detected a significant difference between bisphosphonate group and the control group, as well as between the GIO group and the control group. We also found a significant decrease in osteocyte number by comparing the GIO group to the control group. There was as a significant difference between vitamin D group and control group when we compared the number of osteocyte lacunae in all groups.
<strong> Conclusion: </strong>GIO affects mainly the cortical bone thickness as well as the osteocyte number. Bisphosphonate is possibly the drug of choice in the treatment of osteoporosis especially by increasing the cortical bone thickness. Although olive oil acts also on increasing cortical bone thickness as well as bisphosphonates but it was less effective. On the other hand, vitamin D increases both; the cortical thickness and the osteocyte number moderately and may be used as a prophylactic agent against osteoporosis.
<strong> </strong>
<strong><span style="text-decoration: underline;"> </span></strong>
Osteoporosis – GIO – Bisphosphonates – Vitamin D – Olive oil
https://ejhm.journals.ekb.eg/article_15137.html
https://ejhm.journals.ekb.eg/article_15137_ed3d388ca91d60384888376d2283a053.pdf
Pan Arab League of Continuous Medical Education
The Egyptian Journal of Hospital Medicine
1687-2002
2090-7125
65
1
2016
10
01
Study of Smoking among Females Students in Ibn Sina National Medical College
709
723
EN
Amoutazbillah Abdurahman
Khedrawi
Jeddah Maternity and Children's Hospital
Maha Ali
Alshammari
Battarjee Medical College For Science And Technology
Saleha Hamed
Mabrouk
Ibn Sina National Medical College
Tarnim Muhsen
Alghamdi
Battarjee Medical College For Science And Technology
Alaa Ahmed Mohamed Elmorsy
Elsayed
Battarjee Medical College For Science And Technology
Lujain Osama
Rayes
Battarjee Medical College For Science And Technology
Banan Mohammad Ali
Majrashi
Battarjee Medical College For Science And Technology
Sefa Mehmet Emin
Altun
Battarjee Medical College For Science And Technology
Abdulmajeed Abdullah
Al-Gh amdi
King Abdul-Aziz Hospital & Oncology Center
Abdullah Labib
Almanzalawi
Battarjee Medical College For Science And Technology
Nedaa Hassan
Alshihri
Battarjee Medical College For Science And Technology
Ahmed Yousef
Atiah
Battarjee Medical College For Science And Technology
Qamar Omar
Betrah
Kings Abdul-Aziz University
Alaa Hassan
Mousli
Kings Abdul-Aziz University
Nawaf Faiq
Alsarraj
Kings Abdul-Aziz University
Mohamed Awad
Alqarni
Kings Abdul-Aziz University
Sultan Mohammad
Srougi
Kings Abdul-Aziz University
Ahmed Abdulrahman
Alharbi
Kings Abdul-Aziz University
Ahmed Fahad
Alzahrani
Kings Abdul-Aziz University
Zaher Saleh
Alshehri
Kings Abdul-Aziz University
10.12816/0033787
<strong>Background: </strong>prevention of smoking is a key strategy to improve general health. However, survey data from Jeddah, Saudi Arabia have indicated that a large number of female medical students are addicted to smoking despite the knowledge of its harmful effects. This article comparatively explores the impact of smoking on health among female medical students in Jeddah, Saudi Arabia. Data were collected as part of a program of qualitative and quantitative research investigating the prevalence of smoking among female medical students. <strong>Objectives:</strong>to study the prevalence of smoking among females in the college of ibn Sina and it is impact on their health in relation to personal and family character, CAP knowledge attitude and practice, and association of medical condition as chronic bronchitis and bronchial asthma.
<strong>Methods:</strong>the study was conducted among female’s students attending college of ibn Sina-Jeddah-Saudi Arabia. An open-ended questionnaire was developed to cover the objectives.
<strong>Conclusion: </strong>this study indicated that across the targeted sites, the descriptions made by female smokers about the harmful impact of smoking on their health were often vague. After assessment of the risk factor and variables that may increase prevalence of smoking among medical students, the prevalence of smoking was only 7.95% and used to practice smoking habit despite the knowledge of its side effects.
<strong> </strong>
Smoking cessation,awareness spreading
https://ejhm.journals.ekb.eg/article_15138.html
https://ejhm.journals.ekb.eg/article_15138_8d0b7968cee5b8380ab8456d7333bc6a.pdf