ORIGINAL_ARTICLE
Psychosocial Impacts And Quality of Life of Children With Atopic Dermatitis
This study was conducted on 100 children with atopic dermatitis (AD) attending Dermatology Clinic, Al-Hussein University Hospital and an equal number of children as controls. The aim of the study was to determine the psychosocial impacts of AD on children and their families, to define quality of life (QOL) of children and their families and to determine the relationship between these items and AD severity. A cross-section, analytical, clinic based study design was chosen to perform this research. Criteria for diagnosis of depression and anxiety were according to DSM IV. Also, we used The Children’s Dermatology Life Quality Index and The Dermatitis Family Impact questionnaire to assess the impact of AD on the children’s quality of life and to assess the impact of AD on the quality of family life, respectively. The most common behavioural and psychiatric impacts in children were dependence (33.0%) and anger (26.0%). Also, AD interfered with children’s’ social life and recreation in 73.0% and 29.0% of them, respectively. While, mothers’ psychiatric impacts and family disturbances were more in AD families; 43.0% and 70.0%, respectively. The impacts of AD were more in children and families with severe AD with statistically significant differences. Also, 86.0% of children with AD and 62.0% of their mothers had poor QOL.
https://ejhm.journals.ekb.eg/article_17903_45fd014aa7f8a54a2e0b3cb6266a0bc4.pdf
2006-07-01
401
414
10.21608/ejhm.2006.17903
M. M.
Abu-Sekkien
1
Departments of Paediatrics, Psychiatry Faculty of Medicine, Al-Azhar University
AUTHOR
A. M.
Ebrahim
2
Departments of Paediatrics, Psychiatry Faculty of Medicine, Al-Azhar University
AUTHOR
H. M.
Hassan
3
Dermatology & Venereology Faculty of Medicine, Al-Azhar University
AUTHOR
Y. A.
Baraka
4
Community Medicine Faculty of Medicine, Al-Azhar University
AUTHOR
ORIGINAL_ARTICLE
Assessment of Some Medical Malpractice Cases During Surgical Procedures in Yemen
Aimofwork:-Thisresearchaimstostudysomecasesofmedicalmalpracticeandprovides guidanceformedicalpersonstominimizeorevenavoidmedicalmalpracticeamongYemenis. SubjectsandMethods:-ThisfirststudyinYemenwasdoneonhundredcasesofmedical malpracticeduringsurgerythatwerecollectedrandomlythroughthelasttenyears(1996-2005) frommanyplacesinYemen.Allcaseswereagingfrom3to70yearsold.Thegenderofpatient was54malesand46females.
Results:-Thisstudyshowedhighlysignificantincreaseofnumberofcasesbetweenages21-30, 41-50and51-60inbothsexesascomparedtoothergroupsofage,whileages11-20and31-40 showedsignificantincreaseinnumberofmalpracticecasesversusage61-70years.No significantdifferencebetweenfemalesandmalesamongthestudiedcases.Therewasvery highlystatisticalsignificantincreaseofnumberofmalpracticesthatdonebyonephysician whencomparedtothatdonebytwoorthreephysicians.Therewasveryhighlysignificant increaseinnumberofmalpracticecasesinpublichospitalversusotherhospitalsandinprivate hospitalsversusacademichospitals.Positivecasesofmedicalmalpracticewereveryhighly significantlydecreasedascomparedtonegativeoneinpublicandprivatehospitals&no significantdifferencebetweenpositiveandnegativecasesinacademichospitals.Therewas veryhighlysignificantincreaseinnumberofmalpracticecasesamongspecialistsascompareto universitystaffandconsultant.Therewasnostatisticalsignificantdifferencebetweenuniversity staffandconsultants.Therewasalsoveryhighlysignificantincreaseinnumberofnegative casesamonguniversitystaffandspecialists,butsignificantincreaseofnegativecasesas comparedtopositivecaseswasseenamongconsultants.Thisstudyprovedthatthegeneral surgeryshowedveryhighlysignificantincreaseinnumberofmalpracticecasesversusother groups.Urologyshowedsignificantincreaseinnumberofmalpracticecasesversusinternal medicineandneurosurgery.Itwasdemonstratedveryhighlysignificantincreaseinnumberof malpracticecasesduringintra-operativeandpost-operativestagesversusotherstages. Appendicectomyandcholecystectomyshowedveryhighlysignificantincreaseinnumberof malpracticecasesversusothertypesofoperations.Therewasnostatisticalsignificant differencebetweenthedistributionofcriminalandcivilcasesamongthestudiedcases.A statisticalsignificantdifferencewasshownbetweenthefinaloutcomeinnumberofdeathsand completerecoverywhencomparedwithcasesofpermanentdeformity.
https://ejhm.journals.ekb.eg/article_17906_3dba24a5f96bdeea8324aa3726da5b6d.pdf
2006-07-01
415
429
10.21608/ejhm.2006.17906
Nabil H. S.
AL Hamady
1
Assistant professor, Department of Forensic Medicine and Clinical Toxicology Faculty of Medicine and Health Sciences, Sana’a University.
AUTHOR
ORIGINAL_ARTICLE
Non-fasting Non-High Density Lipoprotein Cholesterol (Non-HDL-C) AS A predictor of Atherosclerosis in Patients with End Stage Renal Disease on Regular Hemodialysis
Fiftypatientswithchronicrenalfailureonregularhemodialysis31malesand19females, agedfrom18to62yearswereincludedinthestudy.Theywereselectedfromthoseattending theNephrologyandDialysisUnitinDamanhourMedicalInstitute.
Tenageandsexmatchedsubjectswithnormalrenalfunctionservedascontrolgroup.Full historytaking,clinicalexamination,restingECGandserumcholesterol,HDL(non-fasting), fastingLDL,non-fastingnon-HDLfromspecialequation,Non-HDL=totalcholesterol-HDL andDuplexscanningofbothcarotidandfemoralarteries.
Nonfastingnon-HDLwasmorethan130mg/dlinmorethan65%ofpatientsgroup versus30%incontrolgroup,serumlevelofnon-fastingcholesterolandnon-fastingnon-HDL weresignificantlyelevatedinhemodialysispatientsascomparedwithcontrolgroup,while serumlevelofnon-fastingHDLandfastingLDLweresignificantlydecreasedinhemodialysis patientsascomparedwithcontrolgroup.Intima-Mediathickness(IMT)ofbothcarotidsand bothfemoralarterieswaselevatedinhemodialysispatientsascomparedwithcontrolgroup. Therewasasignificantpositivecorrelationbetweennon-fastingnon-HDLandIMTofboth carotidsandbothfemoralarteriesandasignificantpositivecorrelationbetweenfastingLDL andIMTofbothcarotidsandfemoralarteries.Therewasasignificantpositivecorrelation betweendurationofdialysisandIMTofbothcarotidsandleftfemoralarteries.
ApositivecorrelationexistsbetweenECGischemicchangesandIMTofbothcarotidsand leftfemoralarteriesandbetweencarotidplaquesandIMTofbothcarotidsandleftfemoral arteries.
Aim of the Work
Tostudyandcomparebetweenthelevelofnon-fastingnon-HDL-CandfastingLDLin predialysisserumaspredictorofatheroscleroticchangesinpatientswithendstagerenaldisease onregularhemodialysis.
https://ejhm.journals.ekb.eg/article_17907_3d0e56b270011c796c25adc4f90e5197.pdf
2006-07-01
430
441
10.21608/ejhm.2006.17907
Sabry
Gohar
1
Internal Medicine Department, Ain Shams University
AUTHOR
Mone
Hosny
2
Internal Medicine Department, Ain Shams University
AUTHOR
Howayda
Abdel-Hamid
3
Internal Medicine Department, Ain Shams University
AUTHOR
Yasser
Ibrahim
4
Damanhour Medical Institute
AUTHOR
ORIGINAL_ARTICLE
Microbiological Study On Respiratory Tract Infections In Libya
Introduction: Recent reports revealed that 10% of the worldwide burden of morbidity and
mortality relates to respiratory tract infection.
Patient and methods: Five hundreds and fifty nine clinical strains were isolated and identified from 322 patients suffering from respiratory tract infections. Patients represented different ages, sexes, and types of infections. Out of the 322 patients, 204 were suffering from upper respiratory tract infections and 118 patients were suffering from lower respiratory tract infections. Patients of upper respiratory tract infections were suffering from chronic suppurative otitis media (63 patients), tonsillitis (50 patients), pharyngitis (48 patients), and sinusitis (43 patients).
Results: Out of the total isolates, Staphylococcus aureus was the most prevalent organism, followed by Streptococcus pyogenes and Klebsiella pneumoniae (17.71, 12.34, and 11.27% respectively). Pseudomonas aeruginosa represented 6.26%. Serratia marcescens and Morganella morganii were the least isolated organisms. The results revealed that 52.42% of the strains were isolated from males and 47.58% from females. Staphylococcus aureus was the most prevalent organism in males (21.16%) while in females Strept. pyogenes was the most prevalent organism (14.29%). Also, the study revealed that Staphylococcus aureus was the most frequent isolate in age groups between 1-20, 21-40 and 41-60 years old (20.85%, 17.02% and 16.67% respectively). However, both Staphylococcus aureus and Klebsiella pneumoniae were isolated with equal incidences, 12% each, in elder patients (more than 60 years). The susceptibility pattern of the isolated bacteria to different antimicrobial agents was studied. Both levofloxacin and gatifloxacin showed the highest activity (100%), followed by ofloxacin and ciprofloxacin (96.44% and 93.39%, respectively). Those are followed by amikacin (91.86%), cefotaxime (89.31%), cefoperazone (86.26%), gentamicin (84.22%), ampicillin-sulbactam (70.48%), amoxycillin-clavulanic (62.34%), cefuroxime (62.09%), lincomycin (61.83%), vancomycin (61.07%), chloramphenicol (57%), cephalexin (48.35%), cephapirin (45.29%), erythromycin (44.78%), and trimethoprim-sulphamethoxazole (43%). Amoxycillin and tetracycline were the least active ((36.64% and 32.06% respectively). Staphylococcus aureus strains resistant to amoxycillin were tested for B-lactamase production. Out of the tested strains, 62.5% were B- lactamase producers and it may be responsible for the resistance to amoxycillin.
In conclusion, the study revealed that evaluation of respiratory tract infections and antimicrobial susceptibility is still in need for more studies. This is due to the continuous development of newly resistant strains and the relatively little number of isolates in some species. Moreover, the differences in the previous antimicrobial treatment, the history of subclinical infections and the immune status of patients involved in each study have increased the difficulty in evaluation.
https://ejhm.journals.ekb.eg/article_17908_01f25671cee2a96a46586334745a099a.pdf
2006-07-01
442
459
10.21608/ejhm.2006.17908
A. H.
Eldeeb
1
Surgery Depantment, Faculty of Medicine , El-Margeb Univ
AUTHOR
E.M.
Khashan.
2
Clinical Pharmacy Depantment, Faculty of Medical Technology, Mesrata, the Great Socialist People’s Libyan Arab Jamahiriya
AUTHOR
ORIGINAL_ARTICLE
Evaluation of the Structural Changes of Extremely Low Frequency Electromagnetic Fields on Brain and Testes of Adult Male Mice
Theincreasingnumberofdevicesemittingmagneticfieldsraisedvalidquestionsconcerning theirsafetyandpotentialriskforhumanexposureanditslimits.Forthispurposefifteenadult micewereexposedtoextremelylowfrequencyelectromagneticfield(ELMF)atafrequencyof 60Hertz(Hz)andintensityof20millitesla(mT)for2hoursfor2consecutivedays.Other10 animalsservedasacontrol.
Aftertheirsacrifice,serumtestosteronewasdetermined.Inaddition,electron microscopicstudyofmicebrainsandtesteswasdone.
ThepresentstudyrevealedthatexposuretoEMFcausedsignificantincreaseinserum testosterone.
Electronmicroscopicexaminationofbraincellsshowedmarkeddemyelinationofnerve fibreswithdegenerationofnervecells.Therewasalsodegenerationofsomespermatogenic cellswithabnormalspermmorphology. Inconclusion,thepresentstudyshowedevidentbiochemicalandhistopathologicalchangesof ELMFonthebrainandtestis.Furtherstudieswouldbeusefultoassesstheeffectofother dosesofexposureandtofollowthedegreeofreversibilityofthesechanges.Other investigationsarealsoadvisabletominimizetheabovebiologicaleffectsandprotectagainst ELMF.
https://ejhm.journals.ekb.eg/article_17909_21079b80917d4339bc05329469afa29c.pdf
2006-07-01
460
476
10.21608/ejhm.2006.17909
Aisha A. Saad El-Din
Saad El-Din
1
National Centre of Radiation Research and Technology, Egypt
AUTHOR
Nabila A.
Abd El-Motaal
2
National Centre of Radiation Research and Technology, Egypt
AUTHOR
Haidy F.
Abd El Hamid
3
Department of Anatomy Faculty of Medicine, Ain Shams University.
AUTHOR
Yasser F.
El-Akid
4
Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Ain Shams University.
AUTHOR
ORIGINAL_ARTICLE
Flow Cytometric Analysis of Peripheral T lymphocyte Subpopulations in Psoriasis
Background : Psoriasis is a common inflammatory skin disorder, has received attention as a target for new pathogenesis and oriented therapies .
Autoimmunity and T lymphocyte subsets are suggested to be involved in the development of psoriasis.
The aim of this work is to asses the role of T lymphocyte subsets in the pathogenesis of psoriasis .
Material And Methods :We investigated the peripheral blood lymphocyte subpopulations obtained from psoriatic patient before and after treatment and from healthy controls, using two colour flow cytometry.
Results :We found highly significant suppression of total CD3+ T Cells and CD3+ CD56+ NKT lymphocytes in psoriatic patient as compared to control. Also, we observed significant reduction of T helper cells in patients as compared to control.
Conclusion : The highly significant reduction of CD3+ T cell and CD3+ CD56+ NKT lymphocytes proved their actively involvement in the development of psoriasis.
https://ejhm.journals.ekb.eg/article_17910_b9f374aea5ec970a3bcd920a23c53d23.pdf
2006-07-01
477
483
10.21608/ejhm.2006.17910
Hanan M.A.
Darwish
1
Departments of Dermatology and Venereology & Clinical pathology Faculty of Medicine for Girls AL-AZhar University
AUTHOR
Nahla M.
Abd EL-Aziz
2
Departments of Dermatology and Venereology & Clinical pathology Faculty of Medicine for Girls AL-AZhar University
LEAD_AUTHOR
Fatma M.
EL-Marzouky
3
Departments of Dermatology and Venereology & Clinical pathology Faculty of Medicine for Girls AL-AZhar University
AUTHOR
ORIGINAL_ARTICLE
Macrophage Migration Inhibitory Factor in Systemic Lupus Erythematosus and its Expression in Lupus Nephritis
Objective: the aim of this study was to access the potential involvement of MIF in SLE, its relationship with corticosteroid dose, also, to measure serum and urinary MIF levels in SLE as well as detecting renal MIF expression in SLE GN.
Methods: Serum and urine MIF concentrations were measured by enzyme-linked immunosorbent assay in 20 SLE female patients with lupus nephritis , World Health Organization class II, III, IV, with mean age of 35.1510.42 years and in 10 normal healthy, age matched, female volunteers. All patients were subjected to detailed clinical assessment and laboratory investigations. Serum and urinary MIF concentrations were measured by ELISA technique. Renal MIF expression was assessed by immunostaining of biopsy tissue. Univariate and multivariate regression analysis were used to examine the associations between serum and urine MIF concentrations, renal MIF expression, disease-related indices of SLE and corticosteroid use.
Results: A statistically significant 2.98-fold-increase was detected in mean urinary MIF (U MIF) levels in SLE patients compared to controls. While, mean Serum MIF (S MIF) showed no significant difference between cases & control. Both S & U MIF concentrations were positively correlated with SLICC/ACR DI but not with SLEIDAI. Corticosteroid doses showed a highly positive correlation with S MIF, serum creatinine & SLICC/ACR DI. Also a positive correlation was found between the different histopathologic grades of renal affection & the U MIF. Immunohistochemistry staining of all normal kidney specimens showed that MIF is constitutively weakly expressed by some glomerular & parietal epithelial cells & by most tubular epithelial cells. In contrast, there was a significant increase in glomerular & tubular MIF protein staining in SLE nephropathy. This increased MIF expression correlated positively with both S MIF and U MIF, SLICC/ACR DI & the daily steroid dose
Conclusion: This study shows that serum MIF is over-expressed in SLE patients and that the urine MIF concentration is significantly increased in SLE World Health Organization class IV patients and correlates with the degree of renal injury. Thus, urine MIF levels reflect MIF expression within the kidney.
https://ejhm.journals.ekb.eg/article_17911_76a32d1fa587ecbac26b03d8ee31cd9d.pdf
2006-07-01
484
500
10.21608/ejhm.2006.17911
SLE
MIF
GN
Renal biopsy
Nahla
Khattab
1
Health Radiation Research Departments Faculty of Medicine Ain Shams University
AUTHOR
Nihad A.
El Nashar
2
Health Radiation Research Departments Faculty of Medicine Ain Shams University
AUTHOR
Nevine
Badr
3
National Centre for Radiation Research & Technology; Physical Medicine & Rehabilitation Department
AUTHOR
Hanan
Fahmy
4
National Centre for Radiation Research & Technology; Physical Medicine & Rehabilitation Department
AUTHOR
Ragia
Fahmy
5
Ain Shams University; Early Cancer d Dtection Unit Department, Ain Shams University Hospitals.
AUTHOR
Amal
Alouba
6
Early Cancer d Dtection Unit Department, Ain Shams University Hospitals.
AUTHOR
ORIGINAL_ARTICLE
Biological studies on fresh water snails target to Schistosoma mansoni infection
Inthisstudy,uponexposureoflaboratoryEgyptianB.alexandrinaandB.glabratasnailsto itshomologusstrainofS.mansoni,twodifferentphenotypestrains"susceptibleandresistant" weredistinguished.Theaimofthisstudyistoinvestigatethebiologicaldifferencesbetween thetwotypesofBiomphalariasnailseithersusceptibleorresistantatdifferentages.The investigatedparametersincludedmortality,survival,percentageofsusceptibility/resistanceto parasiticinfectionandfecundity.Theresultsofthepreliminaryexposureexperimentrevealed thatparentalsnailstockwasnotcompletelysusceptibleandtendtobepartiallyrefractoryto infection.Theresultsalsoshowedastrongassociationbetweenthelevelsofeggproduction andsusceptibilitytoparasiteinfection.Wherebreedingexperimentrevealedthat,totalegg number,E/MandEMvaluesproducedbyresistantphenotypeofbothsnailspeciesweremore thanthoseproducedbysusceptibleprogenysnails.Also,itwasnoticedthat,eggproductionis associatedinverselyproportionwithsnailage.
https://ejhm.journals.ekb.eg/article_17912_a1dafffafa565a43f7b8160499287f5c.pdf
2006-07-01
501
514
10.21608/ejhm.2006.17912
Abdel – Hamid Z.
Abdel – Hamid
1
Medicinal Chemistry Department , National Research Center
AUTHOR
Samia M.
Abd El – Wahab
2
Zoology Department , Faculty of Science , Al – Azhar University for Girls , Cairo , Egyp
AUTHOR
Mona M.
El – Tonsy
3
Zoology Department , Faculty of Science , Al – Azhar University for Girls , Cairo , Egyp
AUTHOR
Rehab M.
Abdel – Megeed
4
Medicinal Chemistry Department , National Research Center
AUTHOR
ORIGINAL_ARTICLE
Plasma Adiponectin and Resistin Levels in Type 2 Diabetic Obese Female Patients With and Without Hypertension and Retinopathy
Background: In the past, adipose tissue was largely regarded as a depot for fuel storage in the form of triglyceride. However, adipose tissue is an active endocrine organ that secretes a variety of metabolically important substances including adipokines. The adipocyte is now known to secrete a variety of proteins such as tumour necrosis factor (TNF)- , adipsin, plasminogen activator inhibitor-1, leptin, resistin, and adiponectin. Adipose tissue regulates insulin sensitivity via the circulating adipocytokines, resistin and adiponectin. These factors affect insulin sensitivity and may represent a link between obesity, insulin resistance and type 2 diabetes (DM). The objective of this study was to compare the levels of resistin and adiponectin in type 2 diabetic obese female patients with and without hypertension and retinopathy.
Subjects and Methods: In this study the plasma adiponectin and resistin concentrations were investigated, in 20 control obese non-diabetic females and 40 obese female patients with type 2 diabetes mellitus. The diabetic females were divided into 2 groups. GI included 20 controlled uncomplicated diabetics & GII included 20 diabetic patients with hypertension and retinopathy.
Results: The plasma concentration of adiponectin was significantly lower (P< 0.01) in diabetic females in GΙ & GΠ than non-diabetic control females. In diabetic patients with hypertension and retinopathy ( GII) there was a significant decrease in plasma adiponectin levels (P< 0.01) as compared to their levels in diabetic females in GΙ and control females. Our results also show that there were non-significant changes in plasma resistin in diabetic patients in both groups GΙ & GII as compared to their levels in control group.
Conclusion: These results suggest that adiponectin may play a key role in pathophysiology of type 2 diabetes mellitus and its microangiopathy and macrovascular complications.
Key words: diabetes mellitus . obesity Introduction
https://ejhm.journals.ekb.eg/article_17914_3e14e7eaa605fbded8ffbb73554ac694.pdf
2006-07-01
515
523
10.21608/ejhm.2006.17914
Seham M. S.
EL – Nakeeb
1
Biochemistry Dept Faculty of Medicine for Girls AL-Azhar University Clinical Pathology Dept
AUTHOR
Manal
A.Lattif
2
Internal Medicine Dept Faculty of Medicine for Girls AL-Azhar University Clinical Pathology Dept
AUTHOR
Ahmed M
.Ragheb
3
Faculty of Medicine AL-Azhar University, Faculty of Medical Technology
AUTHOR
Baker M.A.
Albow
4
Mesalata- El- Margeb University
AUTHOR
ORIGINAL_ARTICLE
The Effect of Monosodium Glutamate (MSG) On Rat Liver And The Ameliorating Effect Of “Guanidino Ethane Sulfonic acid (GES)” (Histological, Histochemical and Electron Microscopy Studies)
Foodadditivesarechemicalsubstancesaddedintentionallytofoodstuffstopreserve, color,sweetenandflavorfood.Monosodiumglutamate(MSG)isusedasaflavorenhancerand foundinmostsoups,saladdressingandprocessedmeat.TheuseofMSGinfoodisgrowing. Irrationalfearhadincreasedinthelastfewyearsduetotheadversereactionsandtoxicityof MSG. ThepresentstudywasdesignedtoinvestigatetheeffectofMSGontheratliverandthe amelioratingeffectoftaurineanalog“Guanidinoethanesulfonicacid(GES)”.Sixtyalbinorats (2-3monthsold)wereusedinthepresentstudy.MSGwasgivenorallyatadailydoseof60 mg/1000gforonemonth,twomonthsandwasgivenatadailydoseof100mg/1000gmforone month.TheresultsrevealedthatthedeleteriouseffectsofMSGweredoserelatedand cumulative.InMSGtreatedrats,theexaminedsectionsshowedremarkablealterationsvaried considerablyfrommoderatestructuralchangestocytoplasmiclysisandsignsofdegenerationof cellularorganelles.Thehistologicalchangesshoweddisturbedliverarchitecture,hemorrhagein thecentralveins,areasofnecrosis,vacuolationandincreasedinflammatorycellsinfiltration. Theglycogengranulesincreasedaswellasthecollagenfibersinthelivercells.Ultrastructural changesshowedlossofcytoplasmicdifferentiation,vacuolation,pyknoticnucleiwithirregular nuclearmembranesandelongatedelectrondensemitochondria.Conversely,treatmentofrats withtaurineanalog(GES)significantlyattenuatedthecellulartoxicityofMSG.
https://ejhm.journals.ekb.eg/article_17916_2c42942a8dd765256f2e9be5949f7fd6.pdf
2006-07-01
524
538
10.21608/ejhm.2006.17916
Hanaa F.
Waer
1
National Center for Radiation Research and Technology, Atomic Energy Authority Faculty of Medicine,Banha University
AUTHOR
Saleh
Edress
2
National Center for Radiation Research and Technology, Atomic Energy Authority Faculty of Medicine,Banha University
AUTHOR
ORIGINAL_ARTICLE
Assessment of Anticardiolipin antibodies, Circulating Lupus anticoagulant, Protein C, Protein S, Antithrombin III &Activated Protein C Resistance and Their Relation to Thomboembolic and Other Clinical Manifestations in Behcet's Disease
Background: Venous and arterial thrombosis occurs in patients with Behcet’s disease and is associated with significant morbidity and mortality. Studies on a possible association between the occurrence of thrombosis and thrombophilia in patients with this disease have been controversial. The objective of this study was to assess the frequency and clinical relevance of anticardiolipin antibodies (aCL) & other thrombophilic factors and their relationship to
thromboembolic & clinical manifestations in Behcet's disease (BD). Materials and methods: IgG, IgM and IgA anticardiolipin antibodies (aCL) isotypes,
presence of circulating lupus anticoagulant(LAC), protein C, protein S, antithrombin III & activated protein C resistance were investigated in 25 patients with BD and 25 patients with various rheumatic diseases not known to be associated with venous or arterial thromboembolic phenomena served as controls. Twelve of the patients with BD (48%) had either deep vein thrombosis (8 patients), arterial thromboembolic phenomena (4 patients), or both (2 patients).
Results: The IgA aCL elevated in14 (56%) patients with BD compared with one (4%) patient in the control group (P<0.01). IgG aCL levels were elevated in 13 (52%) patients with Behcet's disease (BD) compared with one (4%) patient in the control group(P<0.01).Also patients with BD do not have decreased protein S, or antithrombin III activity, activated protein C resistance, circulating lupus anticoagulant (LAC), or elevated LgM aCL. No significant differences were found between any variable in both groups. No association between elevated IgMaCL levels and venous or arterial thrombosis and no statistical correlation was found between any factor and clinical manifestations of the disease.
Conclusion: A significant number of patients have elevated levels of IgA& IgG aCL but they are not associated with venous or arterial thrombosis. These results do not suggest a primary role for aCL in BD and do not support the role of coagulation abnormalities in the pathogenesis of thromboembolic complications of Behcet’s disease but suggest vascular inflammation as the main pathogenetic event in the vascular lesions in Behcet’s disease.
https://ejhm.journals.ekb.eg/article_17919_4432c28c7d842f4e507a43df4cc69c55.pdf
2006-07-01
539
547
10.21608/ejhm.2006.17919
Procoagulant factors
anticardiolipin antibodies
Thromboembolic manifestations
Behcet’s disease
Seham M. S.
EL- Nakeeb
1
Biochemistry Faculty of Medicine AL–Azhar University
AUTHOR
Ahmed M.
Ragheb
2
Clinical Pathology Faculty of Medicine AL–Azhar University
AUTHOR
H.S.
El -Baz
3
Clinical Pathology Faculty of Medicine AL–Azhar University
AUTHOR
Abdel ShafyA.
H
4
Rheumatology and Rehabilitation Dept. Faculty of Medicine AL–Azhar University
AUTHOR
A.M.
Salama
5
Chest Dept. Faculty of Medicine for Girls. AL–Azhar University
AUTHOR
Zeinab A.
Zakzouk
6
Chest Dept. Faculty of Medicine for Girls. AL–Azhar University
AUTHOR
ORIGINAL_ARTICLE
Serum level of IL13 and expression of BCL2 in Behcet’s disease
Background BD: BCL2 family is a large family of apoptosis regulating proteins consisting of both blockers and promoters of cell death. Immunological processes and a variety of cytokines may play a role in pathophysiological process. Defective regulation of programmed cell death (apoptosis) also play a role in development of Behcet’s disease
Objective: To investigate the level of BCL2 and IL13in BD and to determine their to relation monitory disease activity.
Patients and methods: This study was conducted on thirty patients (15 active and 15 inactive) and 15-health control, the activity of BD was evaluated according to international study group for BD disease, using ELISA technique for IL 13 and flow cytometry forBCL2.
Results: Elevated serum levels of IL13 in patient with active BD than inactive and both had elevated levels than control(P< 0.01) and also the serum levels of Bcl2 was elevated in patient with active BD than inactive and control(P< 0.01). Concolusion: The data suggested that IL13 and BCL2 could be involved in the pathogenesis of BD and its serum levels can be used as marker to monitor disease activity.
https://ejhm.journals.ekb.eg/article_17922_34f59fc2d863a5a94d13d7e353f4ddaa.pdf
2006-07-01
548
555
10.21608/ejhm.2006.17922
Hanan.M.A
Darwish
1
Departments of Dermatology and Venereology Faculty of Medicine for girls Al-Azhar University.
AUTHOR
Sabila Gomaa
Mousa
2
General Medicine Faculty of Medicine for girls Al-Azhar University.
AUTHOR
Noha
Hamdy
3
Clinical Pathology, Faculty of Medicine for girls Al-Azhar University.
AUTHOR
Sahar
Zalam
4
Clinical Pathology,Faculty of Medicine for girls Al-Azhar University.
AUTHOR
ORIGINAL_ARTICLE
Copper, Zinc, Selenium, Cadmium and Lead Levels in plasma of Hemodialysis Patients.
Introduction: Hemodialysis patients are at risk of developing trace elements imbalance and increase in heavy metals. Objective: The objective of this study was to asses plasma levels of copper, zinc, selenium, cadmium and lead of hemodialysis patients. Design: The study comprised 40 patients aged 27-65 years under regular hemodialysis for 1.8-13 years and 28 healthy age and sex matched the control. Copper, zinc, selenium, cadmium and lead plasma levels were determined by atomic absorption spectrophotometry. Results: Levels of copper, zinc and selenium were significantly decreased in dialysis patients compared with the control group; the percentage decrease was 25.5%, 20.4% and 19.0% for copper zinc and selenium, respectively. Moreover, cadmium and lead plasma levels showed significant increases among hemodialysis patients versus their matched controls with percentage of 144.6% and 28.1% for cadmium and lead, respectively. Conclusions: Levels of trace elements are altered and heavy metals showed increased plasma levels by hemodialysis. Regular monitoring of trace elements and heavy metals in hemodialytic patients is advisable.
https://ejhm.journals.ekb.eg/article_17923_1c6fbf88564a99965f86d0f9b9bf7084.pdf
2006-07-01
556
563
10.21608/ejhm.2006.17923
Hemodialysis
copper
zinc
selenium
Shawkia S. A.
El-Sherbeny
1
Nutritional Biochemistry Department. National Nutrition Institute
AUTHOR
Asmaa, M.
Abd Allah
2
Clinical Nutrition Department. National Nutrition Institute
AUTHOR
Waleed
Massoud
3
Nephropathy Department-Ahmed Maher Teaching Hospital.
AUTHOR