@article { author = {El-Moselhy, Essam A. and Ammar, Morsy A. and Abd-Allah, Khaled M. and Ismail, Ibrahim A. and Abd-Allah, Eman S.}, title = {Epidemiological Study Of Risky Behaviours And Their Relation With Mental Ill Health Among Secondary School Students In Cairo}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {19}, number = {1}, pages = {1-17}, year = {2005}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.21608/ejhm.2005.18105}, abstract = {A cross-sectional design was carried out on 827 students from general and technical secondary schools in Cairo. The aim of this study was to determine the prevalence of risky behaviours among the studied students, to assess their relation with sociodemographic factors and psychological problems and to explore student’s attitude toward these behaviours. The data were collected by a standardized interviewing form. Different psychological symptoms were assessed using Middle Sex Hospital Questionnaire. The study showed, 54.1% of the students were having unhealthy diet and tobacco smoking behaviours. Also, all the risky behaviours, except absence of physical exercise practice and suicide attempt, were more common among boys. The most important sociodemographic risk factors were; positive family history of risky behaviours, one parent family and the student's work beside studying (OR=7.11, 4.07 and 3.37, respectively). The most important reasons for unhealthy diet, carrying weapon and engagement in casual sex were imitation (55.2%), to feel grown up (47.1%) and peer pressure (39.1%), respectively. While, the most common psychological problem was hysteria (15.1%) and the most common neurotic trait was sadness (41.9%). The most important psychological problems risk factors were obsession and hysteria (OR=5.53 and 4.59, respectively). While, the most important neurotic traits risk were irritability and sadness (OR=9.53 and 8.05, respectively). No awareness to the reported risk was present among 96.4% of the students having the risky behaviours (OR=6.41). }, keywords = {}, url = {https://ejhm.journals.ekb.eg/article_18105.html}, eprint = {https://ejhm.journals.ekb.eg/article_18105_891d381b7fee029fb00f2c17cb2eae66.pdf} } @article { author = {El Sharkawy, Sonia L. and El Shaer, Marwa A. and Badawi, Manal A. and kobeisy, Mohamed H.}, title = {Immunohistochemical Study of Metallothionein Isoform II in Hyperplastic,Dysplastic and Neoplastic Prostatic Lesions}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {19}, number = {1}, pages = {18-27}, year = {2005}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.21608/ejhm.2005.18106}, abstract = {Metallothioneins (MTs) constitute a family of several intracellular, low molecular-weight proteins with a high affinity to various heavy metals. They are involved in metalloregulatory functions such as cell proliferation, growth, and differentiation. The goals of the present study were to investigate the expression of MT in hyperplastic, dysplastic and neoplastic prostatic lesions and to correlate its expression with histologic grade of prostatic carcinoma. This study was performed on Formalin fixed and paraffin embedded tissue blocks from 8 patients with benign prostatic hyperplasia (BPH), 6 patients with prostatic intraepithelial neoplasia (PIN) and 30 patients with prostatic carcinoma (PC) using streptavidin-biotin technique. The histologic grade was defined and the carcinoma cases were divided into 8 low grade (Gleason 2-4), 12 moderate grade (Gleason 5-6) and 10 high grade (Gleason 7-10) carcinoma. Normal and benign prostatic tissues showed patchy MT staining of epithelial cells. All cases of PIN, 20 out of 30 PC cases (66.7%) showed positive staining for MT. MT expression significantly increased from low to high grade tumours. The proportion of MT positively stained cells was directly correlated with histologic grade of PC. The epithelial cells lack uniformity in staining intensity, but the percentage of strongly positive cells increased with increasing the histologic grade of PC. The high incidence of MT expression in PIN in this study suggests that it is associated with early prostate tumorigenesis. Also MT expression was directly correlated with histologic grade of PC suggesting that MT may be a useful marker for predicting prognosis of cancer prostate.  }, keywords = {prostate,Benign Prostatic Hyperplasia,Prostatic intraepithelial neoplasia,prostatic carcinoma,Metallothionein,Immunohistochemistry}, url = {https://ejhm.journals.ekb.eg/article_18106.html}, eprint = {https://ejhm.journals.ekb.eg/article_18106_e4cd6ca9dd73f8192bca46f14f54c1f0.pdf} } @article { author = {Abdel-Bassit, Ahmed and El-Beltagy, Mohammed and Elsaid, Mohammed}, title = {Single Treatment Approaches to Benign paroxysmal Positional Vertigo, Is It Enough?}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {19}, number = {1}, pages = {28-33}, year = {2005}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.21608/ejhm.2005.18107}, abstract = {Bening paroxysmal positional vertigo (B.P.P.V) is one of the most common vestibular disorders.During the last years, it has been attributed to cupulolithiasis or canalithiasis of the posterior semicircular canal.This randomized study was done to determine the effectiveness of two different physical therapy approaches and to determine if a single treatment approaches is enough.In this prospective study 80 patients received either a single treatment based on the hypothesis that the vertigo and nystagmus of (B.P.P.V) are due to debris adhering to the cupula of posterior semicircular canal (cupulolithiasis), Semont maneuver, or a single treatment based on the hypothesis that the debris is free floating in the long arm of the posterior semicircular canal (canalithiasis), Epley maneuver.Treatment outcome was classified as asymptomatic, improved and no change. Analysis of the results of this study revealed that at the end of the first session , out of 80 patients, 60(75%) were asymptomatic ; 14(18%) improved ;6(7%) showed no change. Follow– up showed that 8 patients developed recurrence. After a second session to 22 patients (8 recurrences, 10 improved, 4 had no change) ,17 became asymptomatic.This means that at the end of the seconed session ,69 (86%) of 80 patients became asymptomatic ; 9(11%) of 80 patients improved ; 2(3%) of 80 patients showed no change. In conclusion , this study shows that 1) The success rate of Semont’s maneuver was up to 80%, so it is much better than Epley maneuver 70% after the first session. 2)Recurrent cases are best treated with second session. }, keywords = {}, url = {https://ejhm.journals.ekb.eg/article_18107.html}, eprint = {https://ejhm.journals.ekb.eg/article_18107_7a39f0aaaa11f6b0cc875eaaaf535973.pdf} } @article { author = {Helal, Eman G. E. and Kahwash, Anwaar A. and Mahmoud, Ashraf and Abdel-Rahman, Mervat}, title = {Effect of some medicinal plants on liver and kidney functions in diabetic albino rats}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {19}, number = {1}, pages = {34-47}, year = {2005}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.21608/ejhm.2005.18108}, abstract = {The present study aimed to clarify the effect of aqueous extracts of five plants (Nigella sativa , Aloe vera, Ferula assafoetida, Boswellia carterii Birdw and Commiphora myrrha) and their mixture on liver and kidney functions and protein profiles. Eighty adult male albino rats were divided into eight groups, the first served as control group, other groups were injected with alloxan(120mg/kg b.wt). The second group served as diabetic rats, the third were treated with a mixture (0.1g/100g b.wt), the fourth was treated with Nigella sativa (0.1g/100g b.wt), the fifth was treated with Aloe vera (0.05 g/100g b.wt ), the sixth was treated with Ferula assafoetida (0.1g/100g b.wt), the seventh was treated with Boswellia carterri Birdw (0.1g/100g b.wt) and the eighth group was treated with Commiphora myrrha (0.05 g/100g b.wt ). After thirty days of treatment half of each group was decapitated and the other one was left for 15 days without any additional treatment as recovery period to followup their hazards if present. The results revealed highly significant increase (p<0.01) in serum transaminases (aspartate ( AST ) and alanine (ALT)), alkaline phosphates (ALP), total bilirubin, urea and creatinine and recorded highly significant decrease (p<0.01) in serum total protein , albumin and globulin concentrations in the diabetic group when compared with normal rates. Otherwise, all plants extracts treated groups showed insignificant changes in the previous parameters when compared with control one . It seams, therefore that the water extracts of these plants and their mixture have protective effect against the side effects of alloxan on liver and kidney.  }, keywords = {Liver functions,kidney functions,diabetic Albino rats}, url = {https://ejhm.journals.ekb.eg/article_18108.html}, eprint = {https://ejhm.journals.ekb.eg/article_18108_cd862172017bac0505aa7c7e6245fbea.pdf} } @article { author = {Aggag, Mohamed Farouk and Amin, Ragy Tantawi}, title = {Lateral Ulnar Collateral ligament Lesions in patients with Lateral Epicondylitis: MR Imaging Findings.}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {19}, number = {1}, pages = {48-57}, year = {2005}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.21608/ejhm.2005.18109}, abstract = {Objective. The aim of this work was to determine if a correlation between lateral epicondylitis and abnormalities of the lateral ulnar collateral ligament is found on MR imaging. Subjects and Methods. The Study group comprised 50 consecutive patients who were referred for MR imaging to rule out lateral epicondylitis. On MR imaging “lateral epicondylitis” was defined as increased signal intensity of the extensor tendons close to their insertion on the lateral epicondylitis. The severity of the lateral epicondylitis was graded as mild, moderate or severe. The origin of the lateral colleteral ligamantous complex was characterized and the lateral ulnar collateral ligament was normal, thickened, partially torn or torn. Sixteen patients underwent elbow surgery after the initial MR examination. Results. In 15 patients, MR imaging revealed characteristics of mild lateral epicondylitis. In 13 of these patients the lateral ulnar collateral ligament was normal. One patient showed a thickened lateral ulnar collateral ligament and one patient had a thinned ligament. In 17 patients, MR imaging showed features of moderate lateral epicondylitis. One patient had a thinned ligament feature of moderate lateral epicondylitis. In 14 of these patients, the lateral ulnar collateral ligament was thickened and in the remaining three patients, the ligament was normal All eighteen patients with severe lateral epicondylitis showed abnormalities of the lateral ulnar collateral ligament on MR imaging. In two of these patients, the lateral ulnar collateral ligament was thickened. In Six patients we saw a partial tear, and in the remaining ten patients we saw a complete tear of the ligament. Conclusion. In our study, MR imaging features of lateral epicondylitis were offen associated with thickening and tear of the lateral ulnar collateral ligament and the frequency and severity of lateral ulnar collatered ligament lesions were directly related the severity (degree) of lateral epicondylitis. }, keywords = {}, url = {https://ejhm.journals.ekb.eg/article_18109.html}, eprint = {https://ejhm.journals.ekb.eg/article_18109_85af6406d183172ae20799c393f8abbd.pdf} } @article { author = {Sayed, Lotfy and Ghalli, Mamdoh and Abdelhady, Essam El-Din and Abdelhamid, Ola and Awadalla, Reda}, title = {Effect Of Diazepam On The Prenatal Development Of Neuropil Of The Purkinje Cell Layer Of The Cerebellar Cortex Of The Rats Embryo (Electron Microscope Study)}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {19}, number = {1}, pages = {58-66}, year = {2005}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.21608/ejhm.2005.18110}, abstract = {Diazepam is one of the most widely used sedative hypnotic agents, and many women take this drug during pregnancy. The purpose of this study was to investigate the effects of diazepam on the development of the neuropil of the Purkinje cell layer of the cerebellar cortex. Twenty female pregnant rats were used in this study. The rats were divided into two groups, the first group (5 rats) was used as control group and the second group (15 rats) were given 10 mg/kg/day of diazepam orally and sacrificed at 15th, 20th, 25th days of pregnancy. It was difficult to differentiate between the dendrites and the axonal knobs at 15th day of pregnancy. As age advanced, the dendrites were swollen with absence of cytoplasmic organelles or contained few free ribosomes and immature mitochondria. The observed axonal knobs contained ill-defined synaptic vesicles. Immature axo-dendritic synapses were recognized on the 15th and 20th days of pregnancy, while on the 25th days of pregnancy symmetrical axo-dendritic synapses were recognized. From this study, it appears that the exposure to diazepam causes marked changes on prenatal development of neuropil of the Purkinje cell layer of the cerebellar cortex. Aim of the work The aim of the work was to study the effects of diazepam on the development of the neuropil of Purkinje cell layer of the cerebellar cortex. }, keywords = {}, url = {https://ejhm.journals.ekb.eg/article_18110.html}, eprint = {https://ejhm.journals.ekb.eg/article_18110_feea6da2189734aa55844d2059ca7a4b.pdf} } @article { author = {Mageed, Nabil Abdel and Hassan, Ehsan and Hegazy, Azza and Abdel Wahab, Nagwa M. and Ismail, Sohir A.}, title = {Reproductive Effects Of human Interferon-Alpha-2b Administration on Male Albino Mice Testes.An Experimental Study.}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {19}, number = {1}, pages = {67-78}, year = {2005}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.21608/ejhm.2005.18111}, abstract = {Background: Recombinant human interferon alpha (rh-IFN-α) is used therapeutically in malignant disorders and chronic hepatitis. The phenotypic effects of this drug at the structural levels on testicular tissue were hardly ever addressed. Hence, this work was designed in adult male albino mice to study the phenotypic effects of rh-INF-α-2b on testicular tissue as well as assessing its effects on serum testosterone and gonadotropins levels. Objective: This research was planned to through light on the effects of interferon-alpha- 2b (IFN-alpha-2b) on the hypothalamic-pituitary-testicular (HPT) axis of the adult male albino mice. Design: Experimental study. Setting: National Hepatology and Tropical Medicine Research Institute (NHTMRI). The study was conducted from November (2004) to February (2005). Materials and methods: Thirty sexually mature male mice were divided into three groups (10 mice in each group), namely: the control, the experimental and the recovery groups. Mice in the experimental and recovery groups were administered recombinant human interferon alpha intraperitoneally at a dose of 3000 U / mouse weekly for 12 weeks in a volume of 1.0-microliter isotonic normal saline, then animals in the recovery group were left to recover for a further period of two months. At the end of the experiment, serum concentrations of gonadotropins and testosterone were measured and then all animals were then sacrificed to study histopathologically the possible effects of interferon on the testicular tissue. Results: rh-IFN-α-2b induced remarkable decline in the serum levels of both follicle stimulating hormone (FSH) and luteinizing hormone (LH) in mice of the experimental group compared to the corresponding control and mice of recovery group. At the same time, testosterone was moderately increased in the experimental group, and then returned to its normal levels within 2 months after cessation of treatment. Histopathologically, in the experimental group, there were focal thickening of the basement membrane, degenerative changes and clumping of the germinal epithelial cells in the center of seminiferous tubules, partial desquamation of the germinal epithelium from basement membrane, reduction in the germ cell height, partial arrest of maturation and increased number of Sertoli cells. Increased number of Leydig’s cells and hypervascularity were detected in the interstitial spaces. In the recovery group, there was lessening of the germ cell hypoplasia manifested by restoration of spermatogenic cells and accidental disruption in the basement membrane. Most of the spermatogenic and Sertoli cells restored their polarity, height and maturation. Conclusion: our results suggest that rh-INF-α-2b temporally affects the hypothalamic- pituitary-testicular axis (HPT), both centrally and peripherally (at the testicular level), through the lessening of FSH, LH, raise of testosterone serum levels and direct phenotypic effect on the testicular tissue. 67 }, keywords = {}, url = {https://ejhm.journals.ekb.eg/article_18111.html}, eprint = {https://ejhm.journals.ekb.eg/article_18111_fd4ff99357af70ff5d924a77e3a290da.pdf} } @article { author = {Hassan, H. A. and El-Komy, M. M.}, title = {Effect of lupine (Lupinus termis) seeds or their water extract on alloxan diabetic rats}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {19}, number = {1}, pages = {79-91}, year = {2005}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.21608/ejhm.2005.18112}, abstract = {Diabetes mellitus represents a major public health problem. Much of the increased mortality and morbidity seen in diabetic patients is the result of various complications. Free radicals play an important role in the cause of complications of diabetes mellitus such as retinopathy, nephropathy, hypertension, arteriosclerosis and ischemic heart diseases. Many secondary plant metabolites have been shown to possess antioxidant activities, improving the effects of oxidative stress in diabetic patient. Thus the present study tries to evaluate the role of different preparations from Lupinus termis as a hypoglycemic agent. Alloxan diabetic rats were orally treated with either 5 ml/Kg b.wt/day aqueous lupine seeds extract or 20% w/w in diet edible boiled lupine seeds powder or 20% w/w dry lupine seeds powder for 30 days. The results recorded high levels of glucose, total cholesterol, triglycerides and LDL-cholesterol as well as low levels of total protein, HDL-cholesterol, liver glycogen and serum insulin in diabetic rats. Phospholipids content was increased in the serum but decreased in the liver and pancreas of diabetic rats. In addition, the results confirmed that the alloxan diabetic rats were subjected to oxidative stress as indicated by the extent of lipid peroxidation (high malondialdehide levels) present in the liver and pancreas and significantly alter activities of some scavenging enzymes (low glutathione reductase, glucose-6-phosphate dehydrogenase, superoxide dismutase and catalase). On the other hand, after administration of any one of the used preparations of lupine seeds, the diabetic rats revealed an improvement on various metabolic abnormalities as well as oxidative stress recorded with diabetes but the best improvement occurred in the animal group treated with dry seeds powder. These results give a good evidence for the amelioration effect of lupine against the alloxan diabetic effects.  }, keywords = {Antidiabetic plants,Seed extract,metabolic abnormalities – free radical,alloxan diabetic rats}, url = {https://ejhm.journals.ekb.eg/article_18112.html}, eprint = {https://ejhm.journals.ekb.eg/article_18112_1fd21916636f993e824caf84f3af2b04.pdf} } @article { author = {Sayed, Lotfy and Abdel Hady, Esam Eldin and Hussin, Hosam Eldin and Ibrahim, Atef and Abdelhamid, Ola}, title = {The Protective Effect of Vitamin C on Irradiated Testes of Albino Rat.}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {19}, number = {1}, pages = {92-100}, year = {2005}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.21608/ejhm.2005.18113}, abstract = {The increased exposure to radiation in medicine or industries increases the hazards of radiation on various organs of the human body. The aim of this work was to evaluate the protective effect of anti oxidant (vitamin C) against the effect of radiation on rat testes. Thirty adult albino rats were divided into three groups, each contained ten rats .The first group (G.1) was exposed to 415 r (G.1') or 622 r (G.1") using x-ray source for one minute per day for one week. The second group (G.2) was exposed to 415 r (G.2') or 622 r (G.2") using x- ray source for one minute per day for one week, in addition to vitamin C equivalent to 86.9 mg./liter orally for the two sub groups for the same period . The third group (G.3) was a control group. The examined testes of G.1 showed damaged germinal epithelium with remaining some layers of spermatogonia. There was no affection of spermatocytes, mature sperms, Sertoli cells and Leydig cells, the lumen contained little sperms and debris of germ cells (G.1') .While for (G.1") there was marked damage of the seminiferous tubules with irregular outline, destruction of spermatogonia, spermatocytes and spermatids with pyknotic type of nuclear degeneration and the lumen was devoid of mature sperms. The examined testes of the (G.2) showed evidence of almost complete recovery for G .2' and marked recovery for G.2" It is concluded that anti oxidants were essential to patients exposed to x-ray , to guard against its hazards. }, keywords = {}, url = {https://ejhm.journals.ekb.eg/article_18113.html}, eprint = {https://ejhm.journals.ekb.eg/article_18113_4d4e3715df65a32ffe48db8f36e7ec4d.pdf} } @article { author = {Hassan, Ehsan H. and Abdel Mageed, Nabil and AbdelWahaab, Nagwa and Aref, Hoda and Seif, Sameh}, title = {Effect of Bifendate (DDB) On Normal and Diseased Liver of Adult Male Albino Rats: An Experimental Study.}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {19}, number = {1}, pages = {101-110}, year = {2005}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.21608/ejhm.2005.18114}, abstract = {Background: Fructus Schizandrae Sinensis bail, a traditional Chinese medicine, has been shown to lower the elevated serum level of liver enzymes of patients suffering from chronic active hepatitis. A synthetic derivative compound of Schisandrian, Dimethyl Diphenyl Bicarboxylate (DDB) is now used widely in clinical fields as a hepatoprotective drug. Thus it is important to know whether DDB has a beneficial effect on damaged liver or not. Objective: To evaluate the protective effect of DDB on induced liver tissue injury in rats. Design: Experimental study. Setting: National Hepatology and Tropical Medicine Research Institute. The study was conducted from October (2004) to February (2005). Materials and methods: 120 male albino rats aged 6-8 weeks, weight 150-200g were grouped in six groups, 20 rats per group. Group 1 received food and water only, group 2 received food, water and DDB intragastric 6mg/kg daily for 12 weeks, group 3 received 20% ethanol instead of water, group 4 received 20% ethanol instead of water plus DDB, group 5 received thioacetamide (TAA) in a dose of 200mg/kg body weight intraperitoneal injection, group 6 received thioacetamide plus DDB at the same dose of the above group. At the end of the trial, blood samples were taken from all groups for biochemical analysis. Liver tissue excised from each rat was fixed in 10% neutral formalin, embedded in paraffin, and stained with Hematoxylin and Eosin, as well as Masson’s trichome stain, for evaluation of hepatic injury and/or fibrosis. Results: Statistical elevation of serum hepatic enzymes was noticed in rats received alcohol, Thioacetamide and alcohol + DDB (groups III, V and IV respectively) compared to the corresponding control (P= 0.000). On the other hand, administration of DDB to TAA treated group (group VI) induced significant improvement of liver function tests compared to other groups (P= 0.000). Histopathologically, the control livers showed normal lobular architecture without any pathological changes. Liver sections of animals administered alcohol, TAA respectively showed chronic inflammatory reaction, fat accumulation, hepatic parenchymal necrosis and/or hepatic fibrosis. Administration of DDB resulted in improvement of the pathological changes induced by TAA (group VI), but not that induced by alcohol (group IV). Conclusion: Our results revealed that DDB has antitoxic effect against TAA and ameliorates the dangerous effect on the liver parenchyma, while it has no beneficial effect on alcoholic liver disease.  }, keywords = {}, url = {https://ejhm.journals.ekb.eg/article_18114.html}, eprint = {https://ejhm.journals.ekb.eg/article_18114_174163a6c16d9e5628369a6bc31cdf76.pdf} } @article { author = {Abdel Motaal, Nabila A. R. and Abdel Maguid, Azza}, title = {Effect Of Fractionated And Single Doses Gamma Irradiation On Certain Mammalian Organs}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {19}, number = {1}, pages = {111-122}, year = {2005}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.21608/ejhm.2005.18115}, abstract = {The present work aims to study the effect of fractionated and single dose whole body gamma irradiation on the liver, spleen and intestine of albino rats. 30 Male albino rats (100-120g) were used as experimental animals, they were divided into three groups: The first group consists of 10 rats served as control group (non irradiated), the second group (10 rats) were subjected to a single dose of irradiation (5Gy) and the third group (10 rats) were subjected to gamma of irradiation (5Gy) delivered at 5 successive exposures daily. Histological results showed serious histopathological disorders in the liver, spleen and intestine after exposure to the single dose of gamma irradiation (5Gy), manifested by inflammation and infiltration with mononuclear cells, haemorrhage, dilatation, congestion and widening of blood vessels and necrosis of cells with pyknotic nuclei. Exposure of rats to fractionated doses of whole body gamma irradiation (1Gy) up to 5Gy resulted in less severe histopathological disorders in liver, spleen and small intestine (jejunum), This indicates the beneficial use of fractionated doses in planning for radiotherapy in cancer patients, thus reducing the serious histopathological changes of radiation on the human tissues. }, keywords = {}, url = {https://ejhm.journals.ekb.eg/article_18115.html}, eprint = {https://ejhm.journals.ekb.eg/article_18115_8d3e568cc28457c925e68788b72842a2.pdf} } @article { author = {Selim, Manar Effat}, title = {The Possible Ameliorative Effect Of Dimethyl Dicarboxylate Biphenyl (DDB) Against Mancozeb–Induced Testicular Toxicity In Rats}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {19}, number = {1}, pages = {123-137}, year = {2005}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.21608/ejhm.2005.18116}, abstract = {Mancozeb, an organocarbamate fungicide, has been widely used for several decades. Despite the wide scope of exposure to this compound, up till now, there is a scarcity in published studies on the toxicity of mancozeb and its impacts on cell structure and functions. Thus the present study was designed to investigate the possible counteracting effect of dimethyl dicarboxylate biphenyl (DDB) in reducing the hazards caused by mancozeb in the testies. The effects of mancozeb given separately or simultaneously with DDB on rat testis were studied histologically and ultra structurally. Twenty-one male albino rats were divided into three groups, 7 rats each. The first group was given orally 0.5 ml of distilled water and served as control. Animals of the second group were given mancozeb orally at a dose level of 500 mg/kg b.wt for 15 consecutive days. Animals of the third group received the same dose of mancozeb as in the second group and simultaneously given DDB (50 mg/kg b.wt) through the same route of administration. Mancozeb treatment induced cellular damage manifested as exfoliation and destruction of the spermatogenic lineage. Destructed spermatids and Leydig cells were also pronounced. The ultra structural observations revealed marked cytoplasmic vacuolation in Sertoli cells and spermatogonia. Some cytoplasmic organelles of the spermatogonia and primary spermatocytes were degenerated. Moreover, destructed spermatids were pronounced in most of the seminiferous tubules. The interstitial cells appeared devoid of lipid droplets and the mitochondria appeared with disintegrated cristae. Administration of DDB simultaneously with mancozeb ameliorated most of the testicular tissue damage. This was reflected as restoration of the normal appearance of the spermatogenic lineage. Numerous spermatids were demonstrated in the lumens of the seminiferous tubules, most of them showed similar structure to those of the control group. In conclusion, it is possible to suggest that DDB might have ameliorated and amended the abnormalities caused by mancozeb. }, keywords = {}, url = {https://ejhm.journals.ekb.eg/article_18116.html}, eprint = {https://ejhm.journals.ekb.eg/article_18116_439494f5b7581dbb570ac0834d346d83.pdf} } @article { author = {Ewais, Mohamed M. and Naim, Magda M and El-Baz, Amani A. and Essawy, Soha S.}, title = {Comparison between the effect of the thiazolidinedione-rosiglitazone- & the sulphonylurea -gliclazide- and their combination on the liver of streptozotocin-induced diabetes mellitus in rats.}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {19}, number = {1}, pages = {138-155}, year = {2005}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.21608/ejhm.2005.18117}, abstract = {This study was conducted to compare between the possible effects of rosiglitazone "A new oral antidiabetic drug with selective PPAR-gamma agonistic effect" in a dose of 0.03 mg/kg BW and gliclazide " An oral antidiabetic sulphonylurea" in a dose of 10 mg/kg BW either used alone or in combination, for 6 weeks on the liver, serum glucose and lipid profile in streptozotocin diabetic rats. Thirty rats were randomized into 5 groups (n=6). Group I; the control group was given saline orally daily for 6 weeks. Group II; the streptozotocin induced diabetic group. Group III received rosiglitazone, while group IV received gliclazide and group V received both drugs. The results of the present study revealed that streptozotocin significantly (P< 0.05) elevated serum glucose, cholesterol and triglycerides in rats compared to the controls. The insulin sensitizer "rosiglitazone" either alone or combined with gliclazide decreased serum glucose significantly (P< 0.05) compared to the diabetic group. Gliclazide alone also had the same effect. Rosiglitazone alone decreased serum cholesterol and AST and in combination with gliclazide decreased serum ALT significantly (P< 0.05) compared to the diabetic group. For histopathological study, liver tissue was prepared for both histological (H&E, PAS & Masson’s trichrome) and immunohistochemical (alpha 1 antitrypsin expression) techniques. Both qualitative and quantitative analysis was done to assess the degree of hepatic damage. According to certain criteria, H&E stained sections were quantitatively examined to assess the degree of hepatocyte affection, beside other quantitative measurements (optical density & color area percentage) using the image analyser. Obtained results revealed that streptozotocin caused severeaffectionin6%ofhepatocytes,mildaffectionin2%andmoderateaffectionin41%. The drug also resulted in significant increase in PAS stained glycogen granules in hepatocytes as well as collagen in portal tracts. Immunostaining of alpha 1 antitrypsin revealed increased expression in the lining of blood sinusoids including Kupffer cell cytoplasm and in the area around the central vein. Groups III, IV and V which were under the effect of rosiglitazone, gliclazide or both respectively, showed hepatocyte damage similar to that of diabetic control group; however the degree of that damage was only statistically significantly increased in case of group III. When compared to diabetic control group, these groups (III, IV and V) showed no significant difference in both optical density of PAS positive reaction or mean color area percentage of collagen; however the mean optical density of immunostaining decreased significantly. This indicated that rosiglitazone alone or when used concomitantly with gliclazide, in streptozotocin-induced diabetic rats resulted in improvement of their metabolic control, yet the potential of hepatotoxicity was still to be considered. }, keywords = {}, url = {https://ejhm.journals.ekb.eg/article_18117.html}, eprint = {https://ejhm.journals.ekb.eg/article_18117_802feb2037d499b08f0694dc823c672e.pdf} } @article { author = {Helal, Eman G.E. and Abdel-Rahman, Mervat}, title = {Interaction of sodium nitrite and sunset yellow and its effect on some biochemical parameters in young albino rats}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {19}, number = {1}, pages = {156-167}, year = {2005}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.21608/ejhm.2005.18118}, abstract = {Children usually eat and drink food containing both food preservatives, as sodium nitrite and food colourants, as sunset yellow (S.S.Y) at the same time. The mixture of the two agents at the limited dose of each was found to be lethal. 1/10th of this dose was used daily for 30 days. Animals were divided into three groups. The first served as a control, while the second was orally administered a mixture of sodium nitrite (NaNO3) and S.S.Y. The third received garlic in addition to the above mixture. Half of the animals from each group were decapitated after 30 days of treatment, while the other half was left for another 15 days for recovery. Investigation of the mixture of sod.nitrite and S.S.Y significantly decreases protein and albumin. Significant increases were observed in cholesterol, gamma-glutamyltranspeptidase (GGT), alkaline phosphatase (AP), lactate dehydrogenase (LDH) and creatine phosphokinase (CPK). No change was observed for Total protein, Triglyceride, aspartate aminotransferase (AST), alanine aminotransferase(ALT) and acid phosphatase (AcP) recorded. A complete recovery from the abnormalities of most biochemical parameters was observed after the recovery period or when garlic was administered. This draws attention to the dangers of interactions of such preservatives and colourants. The present study showed that even the permitted doses of colourants and food preservatives may be harmful. And illustrate that usage of garlic may ameliorate some of the expected hazards of food additions.  }, keywords = {Garlic,NaNO3,sunset yellow}, url = {https://ejhm.journals.ekb.eg/article_18118.html}, eprint = {https://ejhm.journals.ekb.eg/article_18118_56bcceb022943b02190670393bbb4fd8.pdf} } @article { author = {Mahmoud, Neveen Hussein}, title = {Ultrastructure Study on the Effect of Alternating Magnetic Field on Mice Liver}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {19}, number = {1}, pages = {168-178}, year = {2005}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.21608/ejhm.2005.18119}, abstract = {Recently, it is recorded that electromagnetic field (E.M.F) is considered dramatically as one of the most dangerous environmental pollutant especially among the developing industrialization societies. The present study aimed to investigate the effect of continuous daily exposure to alternating magnetic field (AC/E.M.F). Adult male mice were classified into three groups. The first group was kept as control. The second group received (50 HZ/AC of 2mT) daily for 20 days. The third group received the same dose and kept for another one month (post treatment) without exposure. Histological and Ultrastuctural studies were carried out on liver tissue using light and electron microscopes. The microscopic examination of the liver specimen of the second group revealed degenerated liver tissue when compared to control group, shrinking rough endoplasmic reticulum, swollen degenerated mitochondria and pyknotic nuclei. Examination of the liver specimens of the third group showed more severe degeneration in comparison with the second group and no sign of recovery was observed. }, keywords = {}, url = {https://ejhm.journals.ekb.eg/article_18119.html}, eprint = {https://ejhm.journals.ekb.eg/article_18119_4300aadce48b3d3c045e8046299cf325.pdf} } @article { author = {Helal, Eman G.E. and Gawish, Abeer S.M. and Kahwash, A.}, title = {Some Hematological-Studice ON Diabetic RATS treated with certain hypoglycemic plants}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {19}, number = {1}, pages = {179-188}, year = {2005}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.21608/ejhm.2005.18120}, abstract = {The present study was designed to evaluate the effect of some antidiabetic plants on the hematological parameters in aloxan induced diabetes in albino rats. Eighty adult albino rats (120-±20 gm b.wt) were randomly divided into eight groups ten on each group, the first group conserved as control group. The remaining rats were injected with alloxan to induce diabetes. The second group conserved as diabetic group. The third group was diabetic rats treated with a mixture consists of Nigella Sativa, Aloe Vera, Ferula assa-foetida , Boswelli Carteri, Commiphora Myrrha. (0.1ml/100gm b.wt), Fourth group treated with 0.1ml/100gm b.w of Nigella Sativa, Fifth group treated with 0.05ml/100gm b.w of Aloe Vera,Sixth group treated with 0.1ml/100gm b.w of Ferula assa- foetida, Seventh group treated with 0.1ml/100gm b.w of Boswelli Carteri, Eighth group treated with 0.1ml/100gm b.w of Commiphora Myrrha. Haematological parameters includes: red blood cell count (RBCs), hemoglobin concentration (Hb), hematocrit value (Hct%), total and differential white blood cell cont (WBCs) were done after 30 days of treatment and after 15 days of recovery period. The result of RBCs count, Hb concentration and Hct value were significantly decreased in diabetic, Nigella Sativa and Aloe Vera treated groups, throughout the experiment, except Aloe Vera treated group showed insignificant change after the recovery period.while insignificant changes was recorded in the remnant groups during the experimental period. WBCs count, lymphocyte and neutrophil percentage were highly significant increased in diabetic and Ferula assa-foetida treated rats after treatment and recovery periods. While insignificant differences were observed in the other treated groups. Moreover, no significant changes were recorded in eosinophils and monocytes in all groups throughout the study period. Diabetes mellitus in experimental animal can be treated with some plants which have antidiabetic effect, the present investigation was designed to illustrate any hazard effect of these plants on some hematological parameter. Further investigations on each plant and their mixture are needed to role out its effect on both diabetes and the vital parameters. }, keywords = {}, url = {https://ejhm.journals.ekb.eg/article_18120.html}, eprint = {https://ejhm.journals.ekb.eg/article_18120_8cf0bff9a6206b2eee6ac3537141e48f.pdf} } @article { author = {Gawish, Azza M.}, title = {Histological Study Of The Effect Of Zinc Sulphate On The Toxicity Of Aluminium Sulphate In Liver And Kidney Of Male Albino Rats}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {19}, number = {1}, pages = {189-197}, year = {2005}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.21608/ejhm.2005.18121}, abstract = {Aluminium (Al) is one of the most abundant and important elements in the environment. In recent years, the production of this metal and its toxicity increased with its discharge into the environment. This study was designed to evaluate the effect of Al intake toxicity in liver and kidney tissues of albino rats and the role of zinc as a protective agent against Al toxicity. Fourty five male albino rats were divided into equal three groups. The first group of animals was considered as control. The animals in the second group were given (50mg/kg/day) of Al sulphate orally using gastric tube for 45 day. Third group were given Al sulphate (50mg/kg/day) followed by zinc sulphate (50mg/kg/day) orally as well as samples of liver and kidney tissues were obtained after 15, 30, 45 days of last doses respectively. Paraffin sections (5μm) were prepared for histological study stained with Haematoxylin & Eosin. The obtained histological results of the histological study of the second group showed that there were congested blood sinusoids and swelling of some hepatocytes within cytoplasm in which there were vacuoles, fragmented nuclei with some cellular infiltration. Kidney tissue showed shrinkage of some glomeruli and distortion of the tubular epithelial cells. Results in the third group, where zinc sulphate was added, showed amelioration and improvement in both liver and kidney tissues. }, keywords = {}, url = {https://ejhm.journals.ekb.eg/article_18121.html}, eprint = {https://ejhm.journals.ekb.eg/article_18121_6714e456a8a632066af2327a79882b1b.pdf} } @article { author = {Shaban, Esmat A.}, title = {Active Immunization Of Rabbit With Gamma Irradiated Cobra (Naja haje) Venom Toxoid}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {19}, number = {1}, pages = {198-207}, year = {2005}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.21608/ejhm.2005.18122}, abstract = {Cobra (Naja haje) venom detoxified by gamma radiation (15KGy or 25KGy) as toxoid for active immunization of rabbits following a short schedule ( on day 0, 7,21) of immunization with complete Freund's adjuvant. Effective neutralization of venom toxin by immune sera of rabbits was observed. The presence of antibody in the immune sera was detected by immuno-diffusion test. The non-irradiated and the two dose levels gamma irradiated Naja haje venom, against the antivenin antibody produced with non-irradiated venom or against antivenin antibody produced with 15 KGy gamma irradiated venom all showed similar patterns. Also there was no change in the titer of antivenin solution obtained from the rabbit immunized with 15KGy irradiated venom , as compared with that antivenin solution obtained from rabbit immunized with non-irradiated venom. Sera of rabbits immunized with 15KGy irradiated venom toxoid (15KGy toxoid antiserum) neutralized venom lethality, 95% of protease activity and 50% of phospholipase A2. }, keywords = {}, url = {https://ejhm.journals.ekb.eg/article_18122.html}, eprint = {https://ejhm.journals.ekb.eg/article_18122_2deb48a59c9e91533e80d5b1d7e48b52.pdf} }