@article { author = {Abu-Sekkien, M. M. and Ebrahim, A. M. and Hassan, H. M. and Baraka, Y. A.}, title = {Psychosocial Impacts And Quality of Life of Children With Atopic Dermatitis}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {24}, number = {1}, pages = {401-414}, year = {2006}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.21608/ejhm.2006.17903}, abstract = {This study was conducted on 100 children with atopic dermatitis (AD) attending Dermatology Clinic, Al-Hussein University Hospital and an equal number of children as controls. The aim of the study was to determine the psychosocial impacts of AD on children and their families, to define quality of life (QOL) of children and their families and to determine the relationship between these items and AD severity. A cross-section, analytical, clinic based study design was chosen to perform this research. Criteria for diagnosis of depression and anxiety were according to DSM IV. Also, we used The Children’s Dermatology Life Quality Index and The Dermatitis Family Impact questionnaire to assess the impact of AD on the children’s quality of life and to assess the impact of AD on the quality of family life, respectively. The most common behavioural and psychiatric impacts in children were dependence (33.0%) and anger (26.0%). Also, AD interfered with children’s’ social life and recreation in 73.0% and 29.0% of them, respectively. While, mothers’ psychiatric impacts and family disturbances were more in AD families; 43.0% and 70.0%, respectively. The impacts of AD were more in children and families with severe AD with statistically significant differences. Also, 86.0% of children with AD and 62.0% of their mothers had poor QOL. }, keywords = {}, url = {https://ejhm.journals.ekb.eg/article_17903.html}, eprint = {https://ejhm.journals.ekb.eg/article_17903_45fd014aa7f8a54a2e0b3cb6266a0bc4.pdf} } @article { author = {AL Hamady, Nabil H. S.}, title = {Assessment of Some Medical Malpractice Cases During Surgical Procedures in Yemen}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {24}, number = {1}, pages = {415-429}, year = {2006}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.21608/ejhm.2006.17906}, abstract = {Aimofwork:-Thisresearchaimstostudysomecasesofmedicalmalpracticeandprovides guidanceformedicalpersonstominimizeorevenavoidmedicalmalpracticeamongYemenis. SubjectsandMethods:-ThisfirststudyinYemenwasdoneonhundredcasesofmedical malpracticeduringsurgerythatwerecollectedrandomlythroughthelasttenyears(1996-2005) frommanyplacesinYemen.Allcaseswereagingfrom3to70yearsold.Thegenderofpatient was54malesand46females. Results:-Thisstudyshowedhighlysignificantincreaseofnumberofcasesbetweenages21-30, 41-50and51-60inbothsexesascomparedtoothergroupsofage,whileages11-20and31-40 showedsignificantincreaseinnumberofmalpracticecasesversusage61-70years.No significantdifferencebetweenfemalesandmalesamongthestudiedcases.Therewasvery highlystatisticalsignificantincreaseofnumberofmalpracticesthatdonebyonephysician whencomparedtothatdonebytwoorthreephysicians.Therewasveryhighlysignificant increaseinnumberofmalpracticecasesinpublichospitalversusotherhospitalsandinprivate hospitalsversusacademichospitals.Positivecasesofmedicalmalpracticewereveryhighly significantlydecreasedascomparedtonegativeoneinpublicandprivatehospitals&no significantdifferencebetweenpositiveandnegativecasesinacademichospitals.Therewas veryhighlysignificantincreaseinnumberofmalpracticecasesamongspecialistsascompareto universitystaffandconsultant.Therewasnostatisticalsignificantdifferencebetweenuniversity staffandconsultants.Therewasalsoveryhighlysignificantincreaseinnumberofnegative casesamonguniversitystaffandspecialists,butsignificantincreaseofnegativecasesas comparedtopositivecaseswasseenamongconsultants.Thisstudyprovedthatthegeneral surgeryshowedveryhighlysignificantincreaseinnumberofmalpracticecasesversusother groups.Urologyshowedsignificantincreaseinnumberofmalpracticecasesversusinternal medicineandneurosurgery.Itwasdemonstratedveryhighlysignificantincreaseinnumberof malpracticecasesduringintra-operativeandpost-operativestagesversusotherstages. Appendicectomyandcholecystectomyshowedveryhighlysignificantincreaseinnumberof malpracticecasesversusothertypesofoperations.Therewasnostatisticalsignificant differencebetweenthedistributionofcriminalandcivilcasesamongthestudiedcases.A statisticalsignificantdifferencewasshownbetweenthefinaloutcomeinnumberofdeathsand completerecoverywhencomparedwithcasesofpermanentdeformity. }, keywords = {}, url = {https://ejhm.journals.ekb.eg/article_17906.html}, eprint = {https://ejhm.journals.ekb.eg/article_17906_3dba24a5f96bdeea8324aa3726da5b6d.pdf} } @article { author = {Gohar, Sabry and Hosny, Mone and Abdel-Hamid, Howayda and Ibrahim, Yasser}, title = {Non-fasting Non-High Density Lipoprotein Cholesterol (Non-HDL-C) AS A predictor of Atherosclerosis in Patients with End Stage Renal Disease on Regular Hemodialysis}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {24}, number = {1}, pages = {430-441}, year = {2006}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.21608/ejhm.2006.17907}, abstract = {Fiftypatientswithchronicrenalfailureonregularhemodialysis31malesand19females, agedfrom18to62yearswereincludedinthestudy.Theywereselectedfromthoseattending theNephrologyandDialysisUnitinDamanhourMedicalInstitute. Tenageandsexmatchedsubjectswithnormalrenalfunctionservedascontrolgroup.Full historytaking,clinicalexamination,restingECGandserumcholesterol,HDL(non-fasting), fastingLDL,non-fastingnon-HDLfromspecialequation,Non-HDL=totalcholesterol-HDL andDuplexscanningofbothcarotidandfemoralarteries. Nonfastingnon-HDLwasmorethan130mg/dlinmorethan65%ofpatientsgroup versus30%incontrolgroup,serumlevelofnon-fastingcholesterolandnon-fastingnon-HDL weresignificantlyelevatedinhemodialysispatientsascomparedwithcontrolgroup,while serumlevelofnon-fastingHDLandfastingLDLweresignificantlydecreasedinhemodialysis patientsascomparedwithcontrolgroup.Intima-Mediathickness(IMT)ofbothcarotidsand bothfemoralarterieswaselevatedinhemodialysispatientsascomparedwithcontrolgroup. Therewasasignificantpositivecorrelationbetweennon-fastingnon-HDLandIMTofboth carotidsandbothfemoralarteriesandasignificantpositivecorrelationbetweenfastingLDL andIMTofbothcarotidsandfemoralarteries.Therewasasignificantpositivecorrelation betweendurationofdialysisandIMTofbothcarotidsandleftfemoralarteries. ApositivecorrelationexistsbetweenECGischemicchangesandIMTofbothcarotidsand leftfemoralarteriesandbetweencarotidplaquesandIMTofbothcarotidsandleftfemoral arteries. Aim of the Work Tostudyandcomparebetweenthelevelofnon-fastingnon-HDL-CandfastingLDLin predialysisserumaspredictorofatheroscleroticchangesinpatientswithendstagerenaldisease onregularhemodialysis. }, keywords = {}, url = {https://ejhm.journals.ekb.eg/article_17907.html}, eprint = {https://ejhm.journals.ekb.eg/article_17907_3d0e56b270011c796c25adc4f90e5197.pdf} } @article { author = {Eldeeb, A. H. and Khashan., E.M.}, title = {Microbiological Study On Respiratory Tract Infections In Libya}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {24}, number = {1}, pages = {442-459}, year = {2006}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.21608/ejhm.2006.17908}, abstract = {Introduction: Recent reports revealed that 10% of the worldwide burden of morbidity and mortality relates to respiratory tract infection. Patient and methods: Five hundreds and fifty nine clinical strains were isolated and identified from 322 patients suffering from respiratory tract infections. Patients represented different ages, sexes, and types of infections. Out of the 322 patients, 204 were suffering from upper respiratory tract infections and 118 patients were suffering from lower respiratory tract infections. Patients of upper respiratory tract infections were suffering from chronic suppurative otitis media (63 patients), tonsillitis (50 patients), pharyngitis (48 patients), and sinusitis (43 patients). Results: Out of the total isolates, Staphylococcus aureus was the most prevalent organism, followed by Streptococcus pyogenes and Klebsiella pneumoniae (17.71, 12.34, and 11.27% respectively). Pseudomonas aeruginosa represented 6.26%. Serratia marcescens and Morganella morganii were the least isolated organisms. The results revealed that 52.42% of the strains were isolated from males and 47.58% from females. Staphylococcus aureus was the most prevalent organism in males (21.16%) while in females Strept. pyogenes was the most prevalent organism (14.29%). Also, the study revealed that Staphylococcus aureus was the most frequent isolate in age groups between 1-20, 21-40 and 41-60 years old (20.85%, 17.02% and 16.67% respectively). However, both Staphylococcus aureus and Klebsiella pneumoniae were isolated with equal incidences, 12% each, in elder patients (more than 60 years). The susceptibility pattern of the isolated bacteria to different antimicrobial agents was studied. Both levofloxacin and gatifloxacin showed the highest activity (100%), followed by ofloxacin and ciprofloxacin (96.44% and 93.39%, respectively). Those are followed by amikacin (91.86%), cefotaxime (89.31%), cefoperazone (86.26%), gentamicin (84.22%), ampicillin-sulbactam (70.48%), amoxycillin-clavulanic (62.34%), cefuroxime (62.09%), lincomycin (61.83%), vancomycin (61.07%), chloramphenicol (57%), cephalexin (48.35%), cephapirin (45.29%), erythromycin (44.78%), and trimethoprim-sulphamethoxazole (43%). Amoxycillin and tetracycline were the least active ((36.64% and 32.06% respectively). Staphylococcus aureus strains resistant to amoxycillin were tested for B-lactamase production. Out of the tested strains, 62.5% were B- lactamase producers and it may be responsible for the resistance to amoxycillin. In conclusion, the study revealed that evaluation of respiratory tract infections and antimicrobial susceptibility is still in need for more studies. This is due to the continuous development of newly resistant strains and the relatively little number of isolates in some species. Moreover, the differences in the previous antimicrobial treatment, the history of subclinical infections and the immune status of patients involved in each study have increased the difficulty in evaluation. }, keywords = {}, url = {https://ejhm.journals.ekb.eg/article_17908.html}, eprint = {https://ejhm.journals.ekb.eg/article_17908_01f25671cee2a96a46586334745a099a.pdf} } @article { author = {Saad El-Din, Aisha A. Saad El-Din and Abd El-Motaal, Nabila A. and Abd El Hamid, Haidy F. and El-Akid, Yasser F.}, title = {Evaluation of the Structural Changes of Extremely Low Frequency Electromagnetic Fields on Brain and Testes of Adult Male Mice}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {24}, number = {1}, pages = {460-476}, year = {2006}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.21608/ejhm.2006.17909}, abstract = {Theincreasingnumberofdevicesemittingmagneticfieldsraisedvalidquestionsconcerning theirsafetyandpotentialriskforhumanexposureanditslimits.Forthispurposefifteenadult micewereexposedtoextremelylowfrequencyelectromagneticfield(ELMF)atafrequencyof 60Hertz(Hz)andintensityof20millitesla(mT)for2hoursfor2consecutivedays.Other10 animalsservedasacontrol. Aftertheirsacrifice,serumtestosteronewasdetermined.Inaddition,electron microscopicstudyofmicebrainsandtesteswasdone. ThepresentstudyrevealedthatexposuretoEMFcausedsignificantincreaseinserum testosterone. Electronmicroscopicexaminationofbraincellsshowedmarkeddemyelinationofnerve fibreswithdegenerationofnervecells.Therewasalsodegenerationofsomespermatogenic cellswithabnormalspermmorphology. Inconclusion,thepresentstudyshowedevidentbiochemicalandhistopathologicalchangesof ELMFonthebrainandtestis.Furtherstudieswouldbeusefultoassesstheeffectofother dosesofexposureandtofollowthedegreeofreversibilityofthesechanges.Other investigationsarealsoadvisabletominimizetheabovebiologicaleffectsandprotectagainst ELMF. }, keywords = {}, url = {https://ejhm.journals.ekb.eg/article_17909.html}, eprint = {https://ejhm.journals.ekb.eg/article_17909_21079b80917d4339bc05329469afa29c.pdf} } @article { author = {Darwish, Hanan M.A. and Abd EL-Aziz, Nahla M. and EL-Marzouky, Fatma M.}, title = {Flow Cytometric Analysis of Peripheral T lymphocyte Subpopulations in Psoriasis}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {24}, number = {1}, pages = {477-483}, year = {2006}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.21608/ejhm.2006.17910}, abstract = {Background : Psoriasis is a common inflammatory skin disorder, has received attention as a target for new pathogenesis and oriented therapies . Autoimmunity and T lymphocyte subsets are suggested to be involved in the development of psoriasis. The aim of this work is to asses the role of T lymphocyte subsets in the pathogenesis of psoriasis . Material And Methods :We investigated the peripheral blood lymphocyte subpopulations obtained from psoriatic patient before and after treatment and from healthy controls, using two colour flow cytometry. Results :We found highly significant suppression of total CD3+ T Cells and CD3+ CD56+ NKT lymphocytes in psoriatic patient as compared to control. Also, we observed significant reduction of T helper cells in patients as compared to control. Conclusion : The highly significant reduction of CD3+ T cell and CD3+ CD56+ NKT lymphocytes proved their actively involvement in the development of psoriasis. }, keywords = {}, url = {https://ejhm.journals.ekb.eg/article_17910.html}, eprint = {https://ejhm.journals.ekb.eg/article_17910_b9f374aea5ec970a3bcd920a23c53d23.pdf} } @article { author = {Khattab, Nahla and El Nashar, Nihad A. and Badr, Nevine and Fahmy, Hanan and Fahmy, Ragia and Alouba, Amal}, title = {Macrophage Migration Inhibitory Factor in Systemic Lupus Erythematosus and its Expression in Lupus Nephritis}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {24}, number = {1}, pages = {484-500}, year = {2006}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.21608/ejhm.2006.17911}, abstract = {Objective: the aim of this study was to access the potential involvement of MIF in SLE, its relationship with corticosteroid dose, also, to measure serum and urinary MIF levels in SLE as well as detecting renal MIF expression in SLE GN. Methods: Serum and urine MIF concentrations were measured by enzyme-linked immunosorbent assay in 20 SLE female patients with lupus nephritis , World Health Organization class II, III, IV, with mean age of 35.1510.42 years and in 10 normal healthy, age matched, female volunteers. All patients were subjected to detailed clinical assessment and laboratory investigations. Serum and urinary MIF concentrations were measured by ELISA technique. Renal MIF expression was assessed by immunostaining of biopsy tissue. Univariate and multivariate regression analysis were used to examine the associations between serum and urine MIF concentrations, renal MIF expression, disease-related indices of SLE and corticosteroid use. Results: A statistically significant 2.98-fold-increase was detected in mean urinary MIF (U MIF) levels in SLE patients compared to controls. While, mean Serum MIF (S MIF) showed no significant difference between cases & control. Both S & U MIF concentrations were positively correlated with SLICC/ACR DI but not with SLEIDAI. Corticosteroid doses showed a highly positive correlation with S MIF, serum creatinine & SLICC/ACR DI. Also a positive correlation was found between the different histopathologic grades of renal affection & the U MIF. Immunohistochemistry staining of all normal kidney specimens showed that MIF is constitutively weakly expressed by some glomerular & parietal epithelial cells & by most tubular epithelial cells. In contrast, there was a significant increase in glomerular & tubular MIF protein staining in SLE nephropathy. This increased MIF expression correlated positively with both S MIF and U MIF, SLICC/ACR DI & the daily steroid dose Conclusion: This study shows that serum MIF is over-expressed in SLE patients and that the urine MIF concentration is significantly increased in SLE World Health Organization class IV patients and correlates with the degree of renal injury. Thus, urine MIF levels reflect MIF expression within the kidney.  }, keywords = {SLE,MIF,GN,Renal biopsy}, url = {https://ejhm.journals.ekb.eg/article_17911.html}, eprint = {https://ejhm.journals.ekb.eg/article_17911_76a32d1fa587ecbac26b03d8ee31cd9d.pdf} } @article { author = {Abdel – Hamid, Abdel – Hamid Z. and Abd El – Wahab, Samia M. and El – Tonsy, Mona M. and Abdel – Megeed, Rehab M.}, title = {Biological studies on fresh water snails target to Schistosoma mansoni infection}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {24}, number = {1}, pages = {501-514}, year = {2006}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.21608/ejhm.2006.17912}, abstract = {Inthisstudy,uponexposureoflaboratoryEgyptianB.alexandrinaandB.glabratasnailsto itshomologusstrainofS.mansoni,twodifferentphenotypestrains"susceptibleandresistant" weredistinguished.Theaimofthisstudyistoinvestigatethebiologicaldifferencesbetween thetwotypesofBiomphalariasnailseithersusceptibleorresistantatdifferentages.The investigatedparametersincludedmortality,survival,percentageofsusceptibility/resistanceto parasiticinfectionandfecundity.Theresultsofthepreliminaryexposureexperimentrevealed thatparentalsnailstockwasnotcompletelysusceptibleandtendtobepartiallyrefractoryto infection.Theresultsalsoshowedastrongassociationbetweenthelevelsofeggproduction andsusceptibilitytoparasiteinfection.Wherebreedingexperimentrevealedthat,totalegg number,E/MandEMvaluesproducedbyresistantphenotypeofbothsnailspeciesweremore thanthoseproducedbysusceptibleprogenysnails.Also,itwasnoticedthat,eggproductionis associatedinverselyproportionwithsnailage. }, keywords = {}, url = {https://ejhm.journals.ekb.eg/article_17912.html}, eprint = {https://ejhm.journals.ekb.eg/article_17912_a1dafffafa565a43f7b8160499287f5c.pdf} } @article { author = {EL – Nakeeb, Seham M. S. and A.Lattif, Manal and .Ragheb, Ahmed M and Albow, Baker M.A.}, title = {Plasma Adiponectin and Resistin Levels in Type 2 Diabetic Obese Female Patients With and Without Hypertension and Retinopathy}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {24}, number = {1}, pages = {515-523}, year = {2006}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.21608/ejhm.2006.17914}, abstract = {Background: In the past, adipose tissue was largely regarded as a depot for fuel storage in the form of triglyceride. However, adipose tissue is an active endocrine organ that secretes a variety of metabolically important substances including adipokines. The adipocyte is now known to secrete a variety of proteins such as tumour necrosis factor (TNF)- , adipsin, plasminogen activator inhibitor-1, leptin, resistin, and adiponectin. Adipose tissue regulates insulin sensitivity via the circulating adipocytokines, resistin and adiponectin. These factors affect insulin sensitivity and may represent a link between obesity, insulin resistance and type 2 diabetes (DM). The objective of this study was to compare the levels of resistin and adiponectin in type 2 diabetic obese female patients with and without hypertension and retinopathy. Subjects and Methods: In this study the plasma adiponectin and resistin concentrations were investigated, in 20 control obese non-diabetic females and 40 obese female patients with type 2 diabetes mellitus. The diabetic females were divided into 2 groups. GI included 20 controlled uncomplicated diabetics & GII included 20 diabetic patients with hypertension and retinopathy. Results: The plasma concentration of adiponectin was significantly lower (P< 0.01) in diabetic females in GΙ & GΠ than non-diabetic control females. In diabetic patients with hypertension and retinopathy ( GII) there was a significant decrease in plasma adiponectin levels (P< 0.01) as compared to their levels in diabetic females in GΙ and control females. Our results also show that there were non-significant changes in plasma resistin in diabetic patients in both groups GΙ & GII as compared to their levels in control group. Conclusion: These results suggest that adiponectin may play a key role in pathophysiology of type 2 diabetes mellitus and its microangiopathy and macrovascular complications. Key words: diabetes mellitus . obesity Introduction  }, keywords = {}, url = {https://ejhm.journals.ekb.eg/article_17914.html}, eprint = {https://ejhm.journals.ekb.eg/article_17914_3e14e7eaa605fbded8ffbb73554ac694.pdf} } @article { author = {Waer, Hanaa F. and Edress, Saleh}, title = {The Effect of Monosodium Glutamate (MSG) On Rat Liver And The Ameliorating Effect Of “Guanidino Ethane Sulfonic acid (GES)” (Histological, Histochemical and Electron Microscopy Studies)}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {24}, number = {1}, pages = {524-538}, year = {2006}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.21608/ejhm.2006.17916}, abstract = {Foodadditivesarechemicalsubstancesaddedintentionallytofoodstuffstopreserve, color,sweetenandflavorfood.Monosodiumglutamate(MSG)isusedasaflavorenhancerand foundinmostsoups,saladdressingandprocessedmeat.TheuseofMSGinfoodisgrowing. Irrationalfearhadincreasedinthelastfewyearsduetotheadversereactionsandtoxicityof MSG. ThepresentstudywasdesignedtoinvestigatetheeffectofMSGontheratliverandthe amelioratingeffectoftaurineanalog“Guanidinoethanesulfonicacid(GES)”.Sixtyalbinorats (2-3monthsold)wereusedinthepresentstudy.MSGwasgivenorallyatadailydoseof60 mg/1000gforonemonth,twomonthsandwasgivenatadailydoseof100mg/1000gmforone month.TheresultsrevealedthatthedeleteriouseffectsofMSGweredoserelatedand cumulative.InMSGtreatedrats,theexaminedsectionsshowedremarkablealterationsvaried considerablyfrommoderatestructuralchangestocytoplasmiclysisandsignsofdegenerationof cellularorganelles.Thehistologicalchangesshoweddisturbedliverarchitecture,hemorrhagein thecentralveins,areasofnecrosis,vacuolationandincreasedinflammatorycellsinfiltration. Theglycogengranulesincreasedaswellasthecollagenfibersinthelivercells.Ultrastructural changesshowedlossofcytoplasmicdifferentiation,vacuolation,pyknoticnucleiwithirregular nuclearmembranesandelongatedelectrondensemitochondria.Conversely,treatmentofrats withtaurineanalog(GES)significantlyattenuatedthecellulartoxicityofMSG. }, keywords = {}, url = {https://ejhm.journals.ekb.eg/article_17916.html}, eprint = {https://ejhm.journals.ekb.eg/article_17916_2c42942a8dd765256f2e9be5949f7fd6.pdf} } @article { author = {EL- Nakeeb, Seham M. S. and Ragheb, Ahmed M. and El -Baz, H.S. and H, Abdel ShafyA. and Salama, A.M. and Zakzouk, Zeinab A.}, title = {Assessment of Anticardiolipin antibodies, Circulating Lupus anticoagulant, Protein C, Protein S, Antithrombin III &Activated Protein C Resistance and Their Relation to Thomboembolic and Other Clinical Manifestations in Behcet's Disease}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {24}, number = {1}, pages = {539-547}, year = {2006}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.21608/ejhm.2006.17919}, abstract = {Background: Venous and arterial thrombosis occurs in patients with Behcet’s disease and is associated with significant morbidity and mortality. Studies on a possible association between the occurrence of thrombosis and thrombophilia in patients with this disease have been controversial. The objective of this study was to assess the frequency and clinical relevance of anticardiolipin antibodies (aCL) & other thrombophilic factors and their relationship to thromboembolic & clinical manifestations in Behcet's disease (BD). Materials and methods: IgG, IgM and IgA anticardiolipin antibodies (aCL) isotypes, presence of circulating lupus anticoagulant(LAC), protein C, protein S, antithrombin III & activated protein C resistance were investigated in 25 patients with BD and 25 patients with various rheumatic diseases not known to be associated with venous or arterial thromboembolic phenomena served as controls. Twelve of the patients with BD (48%) had either deep vein thrombosis (8 patients), arterial thromboembolic phenomena (4 patients), or both (2 patients). Results: The IgA aCL elevated in14 (56%) patients with BD compared with one (4%) patient in the control group (P<0.01). IgG aCL levels were elevated in 13 (52%) patients with Behcet's disease (BD) compared with one (4%) patient in the control group(P<0.01).Also patients with BD do not have decreased protein S, or antithrombin III activity, activated protein C resistance, circulating lupus anticoagulant (LAC), or elevated LgM aCL. No significant differences were found between any variable in both groups. No association between elevated IgMaCL levels and venous or arterial thrombosis and no statistical correlation was found between any factor and clinical manifestations of the disease. Conclusion: A significant number of patients have elevated levels of IgA& IgG aCL but they are not associated with venous or arterial thrombosis. These results do not suggest a primary role for aCL in BD and do not support the role of coagulation abnormalities in the pathogenesis of thromboembolic complications of Behcet’s disease but suggest vascular inflammation as the main pathogenetic event in the vascular lesions in Behcet’s disease.  }, keywords = {Procoagulant factors,anticardiolipin antibodies,Thromboembolic manifestations,Behcet’s disease}, url = {https://ejhm.journals.ekb.eg/article_17919.html}, eprint = {https://ejhm.journals.ekb.eg/article_17919_4432c28c7d842f4e507a43df4cc69c55.pdf} } @article { author = {Darwish, Hanan.M.A and Mousa, Sabila Gomaa and Hamdy, Noha and Zalam, Sahar}, title = {Serum level of IL13 and expression of BCL2 in Behcet’s disease}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {24}, number = {1}, pages = {548-555}, year = {2006}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.21608/ejhm.2006.17922}, abstract = {Background BD: BCL2 family is a large family of apoptosis regulating proteins consisting of both blockers and promoters of cell death. Immunological processes and a variety of cytokines may play a role in pathophysiological process. Defective regulation of programmed cell death (apoptosis) also play a role in development of Behcet’s disease Objective: To investigate the level of BCL2 and IL13in BD and to determine their to relation monitory disease activity. Patients and methods: This study was conducted on thirty patients (15 active and 15 inactive) and 15-health control, the activity of BD was evaluated according to international study group for BD disease, using ELISA technique for IL 13 and flow cytometry forBCL2. Results: Elevated serum levels of IL13 in patient with active BD than inactive and both had elevated levels than control(P< 0.01) and also the serum levels of Bcl2 was elevated in patient with active BD than inactive and control(P< 0.01). Concolusion: The data suggested that IL13 and BCL2 could be involved in the pathogenesis of BD and its serum levels can be used as marker to monitor disease activity. }, keywords = {}, url = {https://ejhm.journals.ekb.eg/article_17922.html}, eprint = {https://ejhm.journals.ekb.eg/article_17922_34f59fc2d863a5a94d13d7e353f4ddaa.pdf} } @article { author = {El-Sherbeny, Shawkia S. A. and Abd Allah, Asmaa, M. and Massoud, Waleed}, title = {Copper, Zinc, Selenium, Cadmium and Lead Levels in plasma of Hemodialysis Patients.}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {24}, number = {1}, pages = {556-563}, year = {2006}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.21608/ejhm.2006.17923}, abstract = {Introduction: Hemodialysis patients are at risk of developing trace elements imbalance and increase in heavy metals. Objective: The objective of this study was to asses plasma levels of copper, zinc, selenium, cadmium and lead of hemodialysis patients. Design: The study comprised 40 patients aged 27-65 years under regular hemodialysis for 1.8-13 years and 28 healthy age and sex matched the control. Copper, zinc, selenium, cadmium and lead plasma levels were determined by atomic absorption spectrophotometry. Results: Levels of copper, zinc and selenium were significantly decreased in dialysis patients compared with the control group; the percentage decrease was 25.5%, 20.4% and 19.0% for copper zinc and selenium, respectively. Moreover, cadmium and lead plasma levels showed significant increases among hemodialysis patients versus their matched controls with percentage of 144.6% and 28.1% for cadmium and lead, respectively. Conclusions: Levels of trace elements are altered and heavy metals showed increased plasma levels by hemodialysis. Regular monitoring of trace elements and heavy metals in hemodialytic patients is advisable.    }, keywords = {Hemodialysis,copper,zinc,selenium}, url = {https://ejhm.journals.ekb.eg/article_17923.html}, eprint = {https://ejhm.journals.ekb.eg/article_17923_1c6fbf88564a99965f86d0f9b9bf7084.pdf} }