@article { author = {Nemenqani, Dalal}, title = {Gastrointestinal Stromal tumor of the stomach and retroperitoneal paraganglioma in Saudi woman, “A case report”}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {46}, number = {1}, pages = {1-6}, year = {2012}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.21608/ejhm.2012.16351}, abstract = {Gastrointestinal stromal tumor (GIST) and paraganglioma are uncommon tumors; mostly occur in a sporadic and isolated form. They are occasionally components of 3 clinical syndromes, familial paraganglioma and gastric GIST, neurofibromatosis type 1 and Carney triad. The latter does not show genetic mutations and affects young women predominantly. This article reports the occurrence of GIST and retroperitoneal paraganglioma in young Saudi woman aged 22 years. The initial clinical presentation was acute severe gastric bleeding. Gastric mass with retroperitoneal mass was discovered during surgical exploration. Histological and immunohistochemical study of both masses showed features of GIST and paraganglioma. The combination of GIST and retroperitoneal paraganglioma in the reported case may be incomplete expression of Carney triad or be coincidental occurrence.  }, keywords = {Gastric GIST,Retroperitoneal paraganglioma,Carney triad,Immunohistochemistry}, url = {https://ejhm.journals.ekb.eg/article_16351.html}, eprint = {https://ejhm.journals.ekb.eg/article_16351_a8e2614b804f26a05b9a7a57be843036.pdf} } @article { author = {ALGhwij, L. M. and Ghoneim, , A. E. and Said, A. E. and Abd-Allah, G. A.}, title = {Effect of Some Herbal Plants on Liver Function of Rats Treated with Trichloroethylene}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {46}, number = {1}, pages = {7-16}, year = {2012}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.21608/ejhm.2012.16352}, abstract = {Background & Aims: Curcumin (CCM), Cinnamon (CNN) and Ginger (GE) had been considered to possess antioxidant activities. This study aimed to investigate their protection effect against trichloroethylene (TCE)-induced hepatotoxicity and to demonstrate its possible mode of action.   Methods: Rats were fed CCM, CNN and GE singly with or without 5mg/l of TCE in drinking water. The rat were killed after treatment period of 8 weeks, and the serum levels of alanine aminotransferase (ALAT), aspartate aminotransferase (ASAT), bilirubin, proteins, glucose, albumin and triglycerides were determined.   Results: TCE- receiving rat exhibited significant changes in biomarkers of liver function to indicate liver injury. The CCM containing diet significantly ameliorated the serum aminotransferases, especially ALAT, total protein and albumin. The CNN containing diet significantly ameliorated the total protein and albumin. The GE containing diet significantly ameliorated the serum aminotransferases, especially ALAT. In conclusion, this work indicated that CCM is the most herbal plant which can protected and alleviated the liver function.    }, keywords = {trichloroethylene,Curcumin,Cinnamon,Ginger,Rats}, url = {https://ejhm.journals.ekb.eg/article_16352.html}, eprint = {https://ejhm.journals.ekb.eg/article_16352_ed576bb8acf9656d1c508b3d20539b80.pdf} } @article { author = {Saad, Tamer M. M.}, title = {Proactive Role of Garlic and Lycopene Extract against Gamma Irradiation-Induced Alterations in Antioxidant Defense Systems in the Brain of Rats}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {46}, number = {1}, pages = {17-25}, year = {2012}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.21608/ejhm.2012.16353}, abstract = {  Radiation protection concepts and philosophy have been evolving over the past several decades. The inadvertent exposure of human from various source of radiation causes Ionization of molecules, setting off potentially damaging reactions via free radicals production. Garlic, Allium sativun, is a member of the lily family that has been cultivated by humans as a food plant for over 10,000 years. Ancient Egyptian used garlic as a remedy for a variety of diseases. Lycopene is a naturally occurring carotenoid found almost exclusively in tomatos and tomato products and the red pigments of the tomato. Lycopene is one of the most potent antioxidants among dietary carotenoids, it exhibits the highest antioxidant activity and singlet oxygen quenching ability of all dietary carotenoids.   Aim   The present study aims to investigate the antioxidative activity of garlic and lycopene extract on the oxidative stress in the damaged brain tissue, irradiated with a single dose of 15 Gy.   Material and Methods    Animals were pretreated with garlic or lycopene by orally administration using suitable stomach tube for one month prior to radiation exposure. The levels of malondialdhyde (MDA), glutathione content (GSH), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) were estimated in brain tissue.   Results    The results revealed that exposure to ionizing radiation resulted in significant elevation in the levels of MDA and (GSH-Px) as well as, significant reduction in SOD, CAT activities and GSH content.   Conclusion     Administration of garlic or lycopene by using suitable stomach tube pre-irradiation has significantly ameliorated the radiation induced disturbances in all of the investigated parameters.  }, keywords = {Ionizing radiation,Garlic,lycopene and Antioxidants}, url = {https://ejhm.journals.ekb.eg/article_16353.html}, eprint = {https://ejhm.journals.ekb.eg/article_16353_a7350820b2b9e33d608ab6f5232c1d80.pdf} } @article { author = {Helal, Eman G.E. and Abd El-Wahab, Samia M. and Zedan, Ghada A. and Sharaf, Atef M. Moussa}, title = {Effect of Zingiber officinale on fatty liver induced by oxytetracycline in albino rats}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {46}, number = {1}, pages = {26-42}, year = {2012}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.21608/ejhm.2012.16354}, abstract = {Abstract Background: Fatty liver causes were markedly increased in Egyptian people throughout last years. People prefer to use the medicinal plants instead of using chemical compounds because they are cheap and have few side effects compared to chemical compounds. Ginger is a natural dietary rhizome with anti- oxidative, anti-inflammatory, and anti-carcinogenic activities. The aim of this study was to evaluate the possible potential therapeutic and protective effects of Zingiber officinale (ginger) against oxytetracyclin- induced fatty liver in an attempt to understand its mechanism of action, which may pave the way for possible therapeutic applications. Material and Methods: Albino rats were divided into two major groups, 15 rats for each. The first group was divided into three sub-groups: a) control, b) fatty liver group; that was injected intraperitonealy with oxytetracycline (120mg/kg) for three consecutive days and c) ginger treated group; which was treated with ginger water extract (125 mg/kg) for 30 days after fatty liver induction . All animals were scarified after 33 days of the beginning of the experiment. The second group was divided into three subgroups: a) control, b) fatty liver group; that was injected intraperitonealy with oxytetracycline (120 mg/kg) for three consecutive days and c) ginger protective group; which received ginger for 15 days before induction of fatty liver, then sacrificed after induction of fatty liver (3 days). Blood samples were collected for biochemical analysis. Liver specimens were obtained and fixed in 10% formalin for histological study. Results: Fatty liver groups showed high significant increase in serum glucose, cholesterol, triglycerides, LDL cholesterol, ALAT, ASAT, GGT, LDH, urea, creatinine and A/G ratio while total protein, albumin, globulin and HDL cholesterol were significantly decreased compared to control group. These biochemical changes were accompanied with histopathological alterations in fatty liver tissue. The treatment with ginger ameliorated most of the evaluated biochemical parameters and improved the induced degenerative histopathological changes. The pre-treatment with ginger before the induction of fatty liver gave some protection against factors that experimentally induced fatty liver. Conclusion: Ginger as diet additive is recommend for fatty liver patients or those people who have hyperlipidemic family history.  }, keywords = {Fatty Liver,Ginger,Lipid profile,Rats,physiological parameters,histopathology}, url = {https://ejhm.journals.ekb.eg/article_16354.html}, eprint = {https://ejhm.journals.ekb.eg/article_16354_dfb0930d5f7a003fd9952a87eb5f12ef.pdf} } @article { author = {Soliman, Ghada, Z A and Saad, Tamer M M}, title = {Fluoride Levels of Mothers’ Breast Milk in Egypt}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {46}, number = {1}, pages = {43-46}, year = {2012}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.21608/ejhm.2012.16355}, abstract = {Introduction: Fluoride exists naturally in water sources and is derived from fluorine. It is well known that fluoride helps, prevent and even reverse the early stages of tooth decay.   Aim: The aim of the present study was to determine the fluoride levels in plasma and breast milk of lactating mothers in Egypt (Cairo and Giza Governorate).   Material and Methods: Two hundred healthy lactating mothers aged between 20-40 years old were asked to give plasma and milk samples voluntary. Breast milk samples were directly refrigerated until measurements. The fluoride concentrations of plasma, milk and drinking tap water were assessed using an ion-selective fluoride electrode combined with an ion analyzer.   Results: The fluoride levels of plasma, breast milk and drinking tap water samples were 0.0207±0.012,0.0111±0.0044 ppm, and 0.482±0.117 ppm, respectively. A significant direct correlation between fluoride content in breast milk and drinking tap water was found (r=0.858, p< 0.01).    }, keywords = {Breast milk,fluoride,Tap water}, url = {https://ejhm.journals.ekb.eg/article_16355.html}, eprint = {https://ejhm.journals.ekb.eg/article_16355_b95d3309ca96de46ed5a9175d975f0d9.pdf} } @article { author = {DH, Abdel Kader and MS, Gabri and MA, Ibrahim and BN, Hassan}, title = {Histological and Immunohistochemical study on the Changes Induced by Contraceptive pills in the female rabbit's kidney}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {46}, number = {1}, pages = {47-63}, year = {2012}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.21608/ejhm.2012.16357}, abstract = { Background:  The mechanism for the development of overt hypertension due to the oral contraception ingestion remains unclear. Experimental evidence favors a role for the renin-angiotensin system. The present study focuses on evaluating the effect of two different contraceptive pills including combined pills (estrogen and progesterone) and mini pills (progesterone only) on the kidney of female rabbit.   Material and methods: After three month of daily oral administration of these contraceptive pills the animals were sacrificed. The excised kidneys were dissected, processed and stained with H & E, PAS and Masson’s trichrome and anti-angiotensin II immunohistochemical stains. This was followed by morphometric measurements and statistical study.   Results: This study revealed that contraceptive pills administration specially the combined one caused marked alterations in the form of damaged kidney tubules with cell swelling and loss of brush border and enlarged glomeruli with hypercellularity. Also, a statistically significant increase in collagenous content peritubular and peri and intraglomerular was observed. There was also a statistically significant increase in the anti-Angiotensin II immunoreactivity in renal tubules as well as intra-glomerular and in the interstitial cells. All these changes were less marked after mini pill treatment.   Conclusion: Progesterone only pills could be safer on the kidney as a contraceptive mean when compared to combined pills.     }, keywords = {combined pills –mini pills- rennin-angiotensin system – angiotensinII- kidney- immunohistochemistry}, url = {https://ejhm.journals.ekb.eg/article_16357.html}, eprint = {https://ejhm.journals.ekb.eg/article_16357_566c8300d4635280c4b60d5c61d11415.pdf} } @article { author = {H, Abu Gabal, and F, Al Shabanat,}, title = {The role of Coenzyme Ubquinone CoQ10 in modulating the changes induced by the antidepressant Venlafaxine in albino rats fetuses}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {46}, number = {1}, pages = {64-82}, year = {2012}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.21608/ejhm.2012.16358}, abstract = {Aim of the work:The present study was done to investigate the role played by CoQ10 in the control of the morphological and histological changes induced in the fetuses of rats injected  by the antidepressant Venlafaxine. Material and methods:  70 pregnant Wister wister rats were injected Intraperitonealy during the organogenesis period  with the antidepressant Venlafaxine (0.25mg /100g.body weight) on day 7of gestation.Mean number of alive embryos,weight  and length of them were recorded with the noticeable malformations beside maternal weights.The protective role of   CoQ10 (0.6 mg. /100g. body weight) was also detected. Results: Venlafaxine injection induced a very highly significant decrease in the mean maternal and fetal body weights, the two horns of the uteri appeared unequal as well as the fetuses were unequally distributed between them, beside the appearance of a lot of resorbed bodies into them, also fat sacs were clear, a case of ectopic pregnancy was obvious, as well as very highly significant decrease in the mean number of alive fetuses was noticed, fetal growth retardation beside lots of rat fetal malformations were observed such as subcutaneous blood bleeding, cleft lips and anomalies of the fore and hind limbs as well as kyphosis of the body.       Intraperitonealy injection of Venlafaxine by the fractionated dose (0.75mg. / 100g body weight) on days 7, 10 and 13 of gestation 0.25mg. /100g each resulted in the death of all the pregnant rats. CoQ10 (0.6 mg. /100g. body weight) orally injected to the pregnant rats before Venlafaxine treatment at the two doses (0.25 and 0.75mg./100g.body weight) improved the above morphometric and morphological as well as the skeletal system changes. Conclusion : CoQ10 (0.6 mg. /100g. body weight) orally injected to the pregnant ratstreated with Venlafaxineshowed protective effect against the dangerous changes induced by this antidepressant.  }, keywords = {}, url = {https://ejhm.journals.ekb.eg/article_16358.html}, eprint = {https://ejhm.journals.ekb.eg/article_16358_4ec5d5cf2c6351d91801f2a4f1527d95.pdf} } @article { author = {Abo Seif, Khaled and Hosny, Mona and Aboud, Ahmed}, title = {Study of Erythropoeitin on IGM serum levels in HCV positive patients on regular HD}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {46}, number = {1}, pages = {83-95}, year = {2012}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.21608/ejhm.2012.16360}, abstract = {Both uremia and HD process cause immunosuppression in HD patients. There was significant increase of total serum IgG and IgM levels found in patients with chronic HCV compared with healthy controls. There is evidence pointing to direct effect of rHuEPO upon B cells. High doses of recombinant human erythropoietin (rHu EPO) enhanced in vitro Ig production and proliferation of various plasma cell lines, as well as human plasma cells generated in vitro. Study was conducted at hemodialysis Unit of Shubra Municipal hospital between August 2010 to February 2011. 30 HCV positive patients on regular hemodialysis were included in study, using bicarbonate dialysate and polysulfone membrane dialyser, for 4 hours 3 times weekly. Patients were divided into 2 groups: first group: 15 patients on EPO therapy. 4000 IU/week and second group not taking EPO for all patients full clinical examination was done, CBC, BUN, serum creatinine, ALT, AST, serum albumin and serum IgM by ELISA (quantitative assay), were done. There was no significant difference between 2 groups as regards age, sex distribution, WBC count, ALT, AST, serum creatinine, BUN and IgM serum level. First group had borderline significant higher Hgband Hct than second group (p = 0.056). Females didn't have higher serum IgM level thanmales (p = 0.403). All correlations of IgM serum level to other parameters of study were irrelevant. Uremia seems to protect ESRD patients on regular HD from complications of HCV and also EPO effect on Ig serum levels.     }, keywords = {Erythropoeitin- IgM –HCV – Hemodialysis}, url = {https://ejhm.journals.ekb.eg/article_16360.html}, eprint = {https://ejhm.journals.ekb.eg/article_16360_d4b1cacb0a0ecfc6bac5d10a47c72ba4.pdf} } @article { author = {Zowail, Mohamed E.M. and Khater, Eman H. S. and Waer, Hanaa F. M. and Eltahawy, Noaman A. and Abd El-hady, Amr M.}, title = {Curative Effect of Bone Marrow Cells Transplantation and/or Low Dose Gamma Irradiation on Liver Injuries Induced by Carbon Tetrachloride}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {46}, number = {1}, pages = {96-114}, year = {2012}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.21608/ejhm.2012.16362}, abstract = {Liver is the most common target for toxic injury. Toxic agents include chemicals such as carbon tetrachloride (CCl4) and trichloroethylene. This study aimed to evaluate the effect of bone marrow cells (BMC) transplantation and/or fractionated low doses (0.5 Gy) gamma radiation on established liver fibrosis induced by CCl4. BMCs of male albino rats were transplanted into 4-weeks carbon tetrachloride (CCl4)–treated and/or fractionated low doses (0.5 Gy) gamma irradiated rats through the tail vein, and the rats were treated for 4 more weeks with CCl4 (total 8 weeks). Histological and ultrastructural investigations revealed that both bone marrow cells transplantation and low dose (0.5 Gy) gamma radiation exposure with continuous CCl4 injection had reduced liver fibrosis as compared with rats treated with CCl4 alone.}, keywords = {}, url = {https://ejhm.journals.ekb.eg/article_16362.html}, eprint = {https://ejhm.journals.ekb.eg/article_16362_056778ee49c88cb1d341c7cb2df70b53.pdf} } @article { author = {Fadel, Hewaida A.E. and Hassanin, Essayed A. and Rihan, Zakaria E. and Abd Allah, Eveleen S.}, title = {Comparative studies on the effect of some antioxidants on renal dysfunction in rats}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {46}, number = {1}, pages = {115-131}, year = {2012}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.21608/ejhm.2012.16364}, abstract = {The present study is carrying out for investigating the effect of supplementation with some vitamins (A, E&C) as natural antioxidant extracts in renal dysfunction in rates.   Material& Methods: 40 adult male Sprague – Dawley rats (150 – 200 g) divided to two groups. First group:  8 rats were fed on standard diet (S.D.), as a control group. Second group: 32 rats were injected intraperitonial with a single dose of Cis-diammine dichloride Platinum II (CDDP) for inducing renal dysfunction (2.5 mg/Kg) then it was divided to six subgroups each one contained 8 rats. (1): fed on (S.D.) nephrotoxic group. (2): fed on (S.D.) + Vitamin A (15 mg/Kg body weight/day). (3): fed on (S.D.) + Vitamin E (317 I.U. /kg body weight/day). (4): fed on (S.D.) + Vitamin C (280 I.U. /kg body weight/day). The experimental period was four weeks, results were statistically analyzed.   Results: The results proved that groups of nephrotoxicity rats supplemented with Vitamin A,E and C showed significant increase in food intakes, body weight gain and food efficiency ratio (FER) (28.9%, 29.4% and 19.2%), (870.5%, 1615.6% and 409.8%) and (652.5%, 122502% and 327.3%) respectively, compared with nephrotoxic group. The nephrotoxicity rats supplemented with Vitamin A and showed significant reduction in serum vitamin E &kidney glutathione content (9.3% & 47.9%), while nephrotoxicity rats supplemented with Vitamin E&C showed significant increase in serum vitamin E &kidney glutathione content (27.9% & 116.6%), (13.7%&55.8%)respectively.  The results showed that nephrotoxicity rats supplemented with Vitamin A,E and C showed significant reduction in serum urea nitrogen and creatinine (48.01% and 55.2%), (52.6% and 60.3%) and (57.0% and 63.04%) respectively. Best results in histopathological examination of kidney were in vitamin A and vitamin C groups.   Conclusion: These results suggest that natural antioxidants could be beneficial as additional therapy in renal dysfunction.    }, keywords = {Natural antioxidants,Renal dysfunction – Nephrotoxicity,Histopathological examination – Kidney function}, url = {https://ejhm.journals.ekb.eg/article_16364.html}, eprint = {https://ejhm.journals.ekb.eg/article_16364_25a2360de8ee3582619cab0820b1fe6d.pdf} }