@article { author = {Arab, Hoda Saeed Mohamed Hassan}, title = {Is Suturless and GluelessLimbal Conjunctival Autograft for Primary Pterygium Surgery Efficient and Safe}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {63}, number = {1}, pages = {127-132}, year = {2016}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.12816/0023838}, abstract = {   Aim of the study:evaluate the safety and efficacy of sutureless glue free limbal conjunctival autograft for the management of primary pterygium surgery.    Material and method:This prospective,interventional randomized,non comparative study was held at AlZahraaUniversity Hospital between May, 2013 and June, 2015. It included 20 eyes of 17 patients, 12 males(70.6%), and 5 females(29.4%). Their mean age±SD was 52.50±18.31 years (Range:30-75 years). They were presented to the outpatient clinic of Al Zahraa University Hospital with primary pterygium. Inclusion criteria included primary pterygium,non atrophic, with healthy conjunctiva. Exclusion criteria included atrophic pterygium, pseudopterygium, ocular surface pathology, infection, previous limbal surgery or double head pterygium. Surgeries were done under local anesthesia. Simple pterygium excision was done leaving a bare sclera. The size of bare sclera was measured. A conjunctival graft 2 mm larger in width and length than the recipient bed was created from the superior temporal quadrantand was extended to the limbus to include limbal stem cells. The graft was gently moved to the recipient bed with the epithelial side up and keeping the limbal edge toward the limbus.Hemostasis was allowed to occur spontaneously without use of cautery to provide autologous fibrin to glue the conjunctival autograft naturally in position without tension.All patients were followed up after 48 hours, weekly for one month then monthly for 12 months.   Results:Pterygia were located nasally in all cases. Pterygia were presented right eye in10(50%) and left eye 10(50%). Mean graft size±SD was 5.5±1.5 millimeter (Range: 5-7 mm). Mean duration of graft fixation ±SD was 10±2.82 minutes (Range:10–12minutes).Mean operative time±SD was 25±1.41 minutes(Range: 24-26 minutes) with good cosmetic outcome in all cases. There was minimal postoperative pain and discomfort, without graft dislocation or dehiscence and without recurrence of pterygia during the follow up period.    Conclusion:Sutureless and gluelessconjunctivallimbalautograft following primary pterygium excision is safe,easy,effective and economic technique in primary pterygium surgery.     }, keywords = {Pterygium,Fibringlue,Limbalautograft,graft retraction,conjunctival edema}, url = {https://ejhm.journals.ekb.eg/article_15192.html}, eprint = {https://ejhm.journals.ekb.eg/article_15192_b66028a296cf35a29830210978b1f5cf.pdf} } @article { author = {Etriby, Adel and Roshdy, Alaa and Wadeaa, Bassem and Abdel Rahman, Mohamed and Abdel Salam, Zeinab and Omar, Yomna}, title = {Incremental Value of 2-Dimensional Longitudinal Radial and Circumferential Speckle Tracking Strain Imaging to Wall Motion Analysis for Detection of Coronary Artery Disease in Patients Undergoing Dobutamine Stress Echocardiography}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {63}, number = {1}, pages = {133-137}, year = {2016}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.12816/0023839}, abstract = {Background: DSE is considered one of the good options in clinical practice but due to some limitations new promising modalities like speckle tracking echocardiography (STE) was introduced. STE is a new imaging technique that allows evaluation of global and regional myocardial function independently from the angle of acquisition and from cardiac translational movements. Objectives: Determine optimal cutoff values for longitudinal, radial and circumferential strains at peak DSE for detection of significant stenosis on CA. Also investigate incremental value of combining strain measurements to wall motion analysis. Methods: The study population comprised 100 patients (age 50 ±9 years) underwent high dose DSE, STE followed by CA. DSE and STE results were compared and added to each other and finally compared to CA result. Results: GLS cutoff points (-16.75%) showed significantly higher accuracy when compared to GCS and GRS, with highest balanced sensitivity and specificity to predict CAD. GLS, GRS and GCS reduced the DSE false positivity by 83%, 72.2% and 66.6% respectively. STE also showed better Agreement with CA than DSE in detecting coronary territorial affection especially LAD (Kappa= 0.775). Conclusions:  STE is feasible during DSE, it helps increasing the diagnostic accuracy of DSE and decreasing its false positivity. Both global and segmental longitudinal strain can offer accurate, feasible and non invasive assessment of CAD.  }, keywords = {Coronary angiography (CA),Coronary artery disease (CAD),Dobutamine stress echocardiography (DSE),Global circumferential strain (GCS),Global longitudinal strain (GLS),Global radial strain (GRS),Left anterior descending (LAD),Left circumflex artery (LCX),Left ventricle (LV),speckle tracking echocardiography (STE),Right coronary artery (RCA),Wall motion score index (WMSI)}, url = {https://ejhm.journals.ekb.eg/article_15194.html}, eprint = {https://ejhm.journals.ekb.eg/article_15194_3e179bda184eb0d5c8ac0c5b7ef28904.pdf} } @article { author = {Salah, Rehab.K and Alkalaldeh, Jelnar .Z and AL-Omari, Nadia Ahmad and AL-Niemat, Sahar and Baninasur, Rasha and Bisharat, Toleen.I}, title = {Electronic Prescribing with a Quick Look for Its Application in Al-Husein Hospital/ Jordanian Royal Medical Services (Jrms)}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {63}, number = {1}, pages = {138-142}, year = {2016}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.12816/0023841}, abstract = {Aim of the study : electronic prescribing is the computer–based electronic generation; it allows a physician to electronically transmit a new prescription to the community or health facility pharmacy. The aim of this study was to evaluate an electronic prescribing patient and physician satisfaction at  AL-Hussein Hospital/(JRMS). Patients and Methods:An electronic prescribing patient satisfaction survey was conducted a sample of 100 patient were randomly chosen.An electronic prescribing physician satisfaction survey was conducted a sample of 50 physician in the specialty clinics of AL- Hussein Hospital were randomly chosen . Results:Around 77% of patient was satisfied that the clinic had adopted electronic prescribing, and around 80% of physician were satisfied that the clinic had adopted electronic prescribing. The feedbacks of patients and physicians were great. Conclusion:This study approved that electronic medical record system improve the quality of patient care and decrease medical errors. Periodic assessment is needed to evaluate many aspect and consequences  of   e-prescribing and to measure the enhancement  in patients and community in addition to achieve  a good resource management .  }, keywords = {Electronic prescribing,Patient,Physician,pharmacist,Satisfaction,computer,medication}, url = {https://ejhm.journals.ekb.eg/article_15197.html}, eprint = {https://ejhm.journals.ekb.eg/article_15197_64d1d99dee605450896527abe0665a81.pdf} } @article { author = {Kamal, Bassam Sobhy and Hassan, Osama Mohamed and El Kilany, Wael Mahmoud and Mohamed, Haitham Galal and Mamdouh, Ahmed Mohamed}, title = {Early Detection of Left Atrial Dysfunction by Speckle Tracking Echocardiography in Hypertensive Patients with Normal Left Atrial Size}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {63}, number = {1}, pages = {143-156}, year = {2016}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {}, abstract = {    Background: Arterial hypertension adversely affects LA size and function, effect on function may precede effect on size. This effect is reflected on patient’s morbidity and mortality risks. Many techniques were used to assess LA function but with many pitfalls.     The objectives: early detection of left atrial dysfunction with speckle tracking echocardiography in hypertensive patients with normal left atrial size.      Patients And Methods: The study was conducted on 50 hypertensive patients and 50 age matched normotensive controls , all with normal LA size and free from any other cardiovascular disease that may affect the LA size or function. They were all subjected to history taking, clinical examination and echocardiographic study, both the conventional measures and speckle tracking then both groups were compared regarding LA strain representing LA function.      Results: Our study found that hypertensive patients had significantly reduced LA function as measured by speckle tracking when compared to normotensive controls (P-value < 0.001). Also, many factors were associated with worse LA function in hypertensive patients as old age, high BMI, DM, LV diastolic dysfunction, high LV mass index, larger LA size, lower LA expansion index and higher systolic BP.      Conclusion: Speckle tracking echocardiography is a useful novel technique in detecting LA dysfunction in hypertension even before LA enlargement occurs.  }, keywords = {Hypertension,left atrium,speckle tracking}, url = {https://ejhm.journals.ekb.eg/article_15199.html}, eprint = {https://ejhm.journals.ekb.eg/article_15199_8e19c38184d3788b5a9bc2c95c23c6fa.pdf} } @article { author = {El Fiky, Azza Abdallah and El Damanhoury, Hayam and Abdel Halim, Walaa Adel and Naguib, Sameh Samir Raafat and El Missiri, Ahmed Mohamed Abou Bakr and Salama, Ahmed Yehia Ramadan}, title = {Assessment of the Role of Speckle Tracking Echocardiography in Targeting the Left Ventricular Lead Position in Patients Undergoing Cardiac Resynchronization Therapy}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {63}, number = {1}, pages = {157-171}, year = {2018}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.12816/0023842}, abstract = {Background: Cardiac Resynchronization Therapy (CRT) is now a well-established treatment for patients with advanced heart failure through biventricular pacing. Optimizing the left ventricular (LV) lead position via echocardiographic speckle tracking guidance could reduce the rate of non-responders to CRT. Objectives: to assess the role of speckle tracking echocardiography in determining the proper position of the left ventricular lead in patients undergoing CRT. Methods: the study population comprised 50 patients who were indicated for CRT according to the ESC 2012 guidelines. Speckle tracking echocardiography was done to all patients before CRT implantation or shortly after implantation while switching off pacing to determine the latest activated myocardial wall of the LV. The patients were classified after CRT implantation into two groups; the first group (group A) included 20 patients and represented those with concordance between the most mechanically delayed myocardial wall derived from speckle tracking echocardiography and the coronary sinus lead position, and the second group (group B) included 30 patients that showed discordance between them. Both groups were recruited for follow-up after a period of 6 months to assess clinical response, echocardiographic response and mortality Results: Significant correlation was observed between echocardiographic response and the LV lead concordance (p value=0.041), and between combined clinical and echocardiographic response and LV lead concordance. There was a nearly significant difference between clinical response and the LV lead concordance (p value=0.057), and there was a trend towards less mortality in the group with concordant LV lead (10.5% in the concordant group versus 24.1% in the discordant group) with no statistical significance (p value=0.286). Conclusions: we demonstrated an increased benefit with an echocardiographically optimized LV lead position targeting the most delayed myocardial wall by 2D speckle tracking echocardiography.  }, keywords = {resynchronization,speckle tracking,Strain,Dyssynchrony}, url = {https://ejhm.journals.ekb.eg/article_15213.html}, eprint = {https://ejhm.journals.ekb.eg/article_15213_418261deb4b43133fd6dc55c5724476d.pdf} } @article { author = {Ahmed, Sara Ahmed Sayed and Eldosoky, Mohamed A. A. and El- Wakad, Mohamed Tarek and Agamy, Emad MTM}, title = {Effect of Stiffness of Single Implant Supported Crowns on the Resultant Stresses. A Finite Element Analysis}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {63}, number = {1}, pages = {172-184}, year = {2018}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.12816/0023843}, abstract = { Objective: In the present study, the 3D finite element method was used to investigate the effect of crown material on stress distribution in the bone surrounding immediately loaded single dental. Materials & Methods: A 3D Finite Element model of mandibular first premolar was constructed to evaluate the performance of seven crown materials with different degree of stiffness (Porcelain, zirconium, Porcelain fused to gold, pure titanium, titanium alloy, Poly methyl methacrylate, and Polyether ether ketone PEEK). The model was constructed using Solid Works version 2010 software. The model simulated also a cement layer between the implant abutment and the crown (Virolink II, Vivadent). An axial static occlusal force of 200 N was applied to eight points in each functional cusp. The three-dimensional (3D) FE model was analyzed by ABAQUS/CAE version 6.10 software.  Results: The results of this study indicated that among all crown materials the maximum von Mises stress values was observed in porcelain crown design (345.390 MPa).The highest von Mises stresses were found in the abutments for all models. In implants, the greatest stress was concentrated on the cervical region. PMMA and PEEK crown designs transferred less stress to abutment and screw. In all models, von Mises stresses increased in the coronal third of cortical bone in which the maximum von Mises stresses observed in the implant – cortical interface. Conclusions: Using more rigid material for the superstructure of an implant supports prosthesis did not have any effect on the stress values and stress distribution at the bone tissue surrounding implant. However, in the abutment, cement and crown structure, stress distributions and localizations were affected by the material’s rigidity. More clinical studies are needed to evaluate the survival rate of these materials.  }, keywords = {dental implant,Finite Element Analysis,prosthetic materials,immediate loading}, url = {https://ejhm.journals.ekb.eg/article_15214.html}, eprint = {https://ejhm.journals.ekb.eg/article_15214_7420591cf98aa6cb0f0bbc4284fd4b64.pdf} } @article { author = {Al-Etreby, Ezzat A. and Abd El-Aziz, Ayaman and El-Waseef, Osama and El-Moselhy, Essam A.}, title = {The Association between Hypoalbuminemia and Intradialytic Hypotension in Heamodialysis Patients}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {63}, number = {1}, pages = {185-194}, year = {2018}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.12816/0023844}, abstract = {Background: hypoalbuminemia is an important risk factor of hypotension during hemodialysis and progressive left ventricular hypertrophy in patients with chronic kidney disease (CKD). Aim of the study: this study was done to evaluate the relationship between serum albumin and intradialytic hypotension (IDH) and cardiac functions. Patients and Methods: forty patients on regular hemodialysis (HD) were included in the present study. They have been divided into two groups; Group 1: Patients of this group developed recurrent attacks of IDH and Group 2: Patients of this group not developed IDH. The patients have been classified again according to serum albumin level into two groups; Group A: Hypoalbuminemic patients and Group B: Non-hypoalbuminemic patients. Data collected from each patient included: (1) Demographic features (age, gender) and clinical features (blood pressure changes during session, ultrafiltration rate, cardiothoracic ratio, duration of dialysis and Kt/V); (2) Blood chemistry (creatinine, urea, hemoglobin, hematocrit value, total proteins, albumin, triglycerides, cholesterol, AST, ALT, Kt/V, and fasting blood sugar); and (3) Echocardiographic assessment of left ventricular geometry. Results: there was a significant negative correlation between serum albumin and Delta BP in HD patients. Also we found no significant changes in cardiac functions among different studied groups. Conclusion: We concluded that there was a relationship between low serum albumin and intradialytic hypotention and cardiac functions in CKD patients undergoing HD. Recommendations: Regular assessment of serum albumin is mandatory for all HD patients.  }, keywords = {Heamodialysis,Hypoalbuminemia,risk factor,Intradialytic hypotension}, url = {https://ejhm.journals.ekb.eg/article_15215.html}, eprint = {https://ejhm.journals.ekb.eg/article_15215_f04cb52ec2a99dd40e0a8b7784f5b074.pdf} } @article { author = {Y. M, Hodeeb and Al Dinary, Amal M. and Abd El-galil, Heba M. and Hammour, Zeinab El-sayed and H. S, Ibrahim}, title = {Relation of Body Mass Index and Waist Circumference to Some Fertility Markers among Male Partner of Infertile Couples}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {63}, number = {1}, pages = {195-205}, year = {2018}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.12816/0023845}, abstract = {Background: Global estimates of infertility range between 8% and 12% of couples with women of childbearing age, affecting 50–80 million people. Excess weight is not only linked to increasedrisk of chronic disease but has also been shown to increase risk of reproductive problems. The consequences of obesity in female fertility have been widely studied, but studies in the male population are less frequent. Aim of the study: The aim of this study to clarify the role of body mass Index and waist circumference on some male-fertility laboratory markers among Egyptian males of infertile couples. Subjects and methods: A descriptive cross sectional studywas carried out on a total sample of 59 males of infertile couples for at least one year after regular unprotected reproductive activity. BMI and WC were assessed, and a morning blood sample was taken assessing serum levels of testosterone, sex hormone-binding globulin, prolactin, luteinizing hormone (LH), follicle-stimulating hormone, and estradiol. Semen-analysis parameters were also measured. Results:  In the present study, it was found that there was no statistical significant difference in relation of BMI or WC and sperm count. The likelihood of athenospermia was increased at higher BMI and WC values. BMI was not found to be associated with mean numeric values of the semen-analysis parameters, including sperm count, sperm morphology, and sperm motility. BMI was not significantly correlated with some hormone levels, such as LH and prolactin. However, a statistically significant inverse correlations was observed between WC and testosterone (r=-0.3&p=0.04). A different pattern of associations in this study was observed when the associations between BMI &WC and sexual hormone levels were compared between (fertile and subfertile) from infertile men. Conclusion: The association explored between WC and testosterone as well as different patterns of this association between (fertile and subfertile) from infertile men.  }, keywords = {Male infertility,Body Mass Index,waist circumference,sperm analysis,Sexual hormones}, url = {https://ejhm.journals.ekb.eg/article_15216.html}, eprint = {https://ejhm.journals.ekb.eg/article_15216_5bdc44045a8f81880592dbc8eb6cd4be.pdf} } @article { author = {El Nashar, Nihad and Hatem, Mohamed}, title = {Prognostic Roles of Endostatin, Matrix Metalloproteinase-2 & 9 and Tissue Inhibitors of Metalloproteinase-1in Advanced Non-Small Cell Lung Cancer}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {63}, number = {1}, pages = {206-209}, year = {2018}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.12816/0023846}, abstract = {Background and aim of the work: Previous studies verified that Endostatin, matrix metalloproteinase (MMP) -2 and -9, in addition to tissue inhibitors of metalloproteinase (TIMP) -1 may play a crucial role in prognosis of non-small cell lung cancer (NSCLC). In this study we will investigate the changes in the pretreatment serum levels of these factors and to evaluate their clinical implication in patients with advanced non-small cell lung cancer (NSCLC). Patients and methods: Pretreatment serum samples were collected from 25 patients and 10 control healthy individuals. The levels of Endostatin, MMP-2, MMP-9, and TIMP-1 were measured using a sandwich enzyme immunoassay kit. Results: The pretreatment serum levels of Endostatin and TIMP1 were significantly elevated and correlated with their stages and survival (P< 0.05), where, the serum level of Endostatin in healthy subjects was 81.20±23.99 ng/ml and in patients with NSCLC was 354.40 ± 164.01 ng/ml. The serum level of TIMP1 in healthy subjects was 1.49±0.29 ng/ml and in patients with NSCLC was 2.96±0.58 ng/ml. The serum level of MMP2 and 9 were non-significantly decreased in serum of NSCLC patients (P > 0.05), where the serum activity of MMP2 in healthy subjects was 0.14±0.03 ng/ml and in patients with NSCLC was 0.09±0.03 % and the serum activity of MMP9 in healthy subjects was 0.13±0.019 ng/ml and in patients with NSCLC was 0.10±0.03 %.  Conclusions: Our results indicated that the circulating levels of Endostatin, and TIMP-1 in patients with NSCLC may be valuable future tools for treatment planning and monitoring of treatment, however, these blood tests need to be standardized and validated in large-scale prospective clinical trials.  }, keywords = {Endostatin,matrix metalloproteinase,tissue inhibitors of metalloproteinase,non small cell lung cancer}, url = {https://ejhm.journals.ekb.eg/article_15217.html}, eprint = {https://ejhm.journals.ekb.eg/article_15217_78085f7bff4edef66f1ed37c065cafd1.pdf} } @article { author = {Al Mourgi, Majed and Hussein, Ahmad Haj and Abdel-Rahman, Tamer and Badr, Samir and Alsayali, Reem and Al-Sawat, Samah and Alsayali, Rana}, title = {Uniportal Therapeutic Video-Assisted Thoracoscopic Surgery: A Single Hospital Experience, Taif Saudi Arabia}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {63}, number = {1}, pages = {210-212}, year = {2018}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.12816/0023847}, abstract = {Background and aim of the work: Therapeutic uniportal video-assisted thoracic surgery (VATS) has less postoperative pain, shorter hospital stay, and less operative time. In this study we will present our experience in therapeutic VATS at King Abdul Aziz Specialist Hospital, Taif Saudi Arabia.  Patients and methods: This retrospective study was conducted in King Abdul Aziz Specialist Hospital, Taif, Saudi Arabia, from July 2012 to January 2016 and included 162 patients who were admitted to the hospital in this period and therapeutic uniportal VATS was conducted for them. Results: The 162 patients were 102 males (63%) and 60 females with mean age of 45.1±6.8years. Bilateral sympathectomy was performed for palmar hyperhidrosis in 36% of cases, VATS stapled blebectomy with apical pleurectomy were performed for primary spontaneous pneumothorax in 32% of cases, wedge resections in 23.5%, adhesiolysis was performed in 5%, and in3.7% anatomical segment resections was done. Mean operative time was 25.5±5.5 minutes. The mean hospital stay was 5.3±1.2 days. No operative or early postoperative mortality was recorded.  Conclusion: Uniportal VATS was proved to be safe and effective and can replace the multiportal approach in the management of various disorders which require thoracic surgery.  }, keywords = {Video-assisted thoracic surgery (VATS),uniportal VATS,uniportal sympathectomy,uniportal blebectomy,uniportal pleurodesis,Taif,Saudi Arabia}, url = {https://ejhm.journals.ekb.eg/article_15218.html}, eprint = {https://ejhm.journals.ekb.eg/article_15218_a055738eec39485cd7332ee358ef6f90.pdf} } @article { author = {Nassar, Ahmed Ibrahim and Hanna, Hany Fouad and Mohamed, Haytham Galal and Andrawes, Amir Wadie and Ragy, Hany Ibrahim}, title = {Routine Early Coronary Angioplasty versus Ischaemia-Guided Coronary Angioplasty after Successful Thrombolysis in Patients with Acute Anterior STEMI}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {63}, number = {1}, pages = {213-216}, year = {2018}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.12816/0023849}, abstract = {Background: the potential benefits of routine early intervention after thrombolysis include prevention of re-infarction, recurrent ischemia, and reduction of the infarct size and mortality. Aim of the work: the purpose of this study is to compare routine early coronary angioplasty in patients with acute anterior STEMI after successful thrombolysis versus ischaemia-guided coronary angioplastyas regards the occurrence of MACCE. Study design: a total number of 100 patients with acute anterior STEMI received thrombolytic therapy and then were randomly assigned to either routine invasive strategy or ischemia based strategy based on risk stratification by stress myocardial perfusion scan done within 30 days of the onset of AMI with subsequent CA after demonstration of residual myocardial ischemia and or good viability. Results: the cumulative incidence of MACCE including recurrent ischemia, stroke, MI, HF or mortality was significantly lower in theroutine early invasive strategy. Conclusion: STEMI patients who cannot undergo timely primary PCI should receive prompt fibrinolysis followed by early routine invasive strategy.  }, keywords = {Pharmaco-invasive PCI}, url = {https://ejhm.journals.ekb.eg/article_15219.html}, eprint = {https://ejhm.journals.ekb.eg/article_15219_beaec6ce5c0179f3f7fc0d72912625c6.pdf} } @article { author = {H, Abu Gabal and M, Al Waely}, title = {Role of Astaxanthin in Improving the Physiological and Teratolgical Changes of Aspartame in the Pregnant Albino rats and Their Fetuses}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {63}, number = {1}, pages = {217-228}, year = {2018}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.12816/0023850}, abstract = {Aim of the work: the present work was done to investigate the role of astaxanthin in ameliorating the physiological and teratological effects of aspartame on the pregnant rats and their fetuses. Materials and methods: in this study 70 virgin mature female albino rats (Wistar wistar) were used and 35 males (for mating); pregnancy was ascertained by vaginal smearing. The pregnant rats were injected on days7, 9, 11 and 13 of gestation (organogenesis period). The animals were divided into the following groups: animals of the first group which were intraperitoneally injected with 0.5ml saline (solvent of aspartame); animals of the second were intraperitoneally injected with 0.5 ml olive oil (solvent of astaxanthin). The third group was divided into 2 subgroups, the pregnant rats of the first subgroup were intraperitoneally injected with aspartame (20mg./kg. body weight), the pregnant rats of the second subgroup were intraperitoneally injected with aspartame (40 mg./kg. body weight). Pregnant rats of the 4th group were intraperitoneally injected with astaxanthin (50mg.\kg. body weight) 2 hours after aspartame injection by its 2 doses. Results: aspartame at the dose of  40 mg./kg.body weight induced pre- term ( early delivery); however the 2 doses of aspartame resulted in very highly significant decrease in the mean maternal body weight , unequal horns of the uteri and unequal distribution of the fetuses between them , abnormal amount of fats surrounding the 2 horns of the uterus, regions of hemorrhage were present on the external membrane of the uteri ,very highly significant uterine weight decrease , cases of abortion were noticed as well as highly significant increased resorption of the fetuses. Intraperitoneal injection with aspartame at the 2 doses resulted in fetal mortality, very highly significant fetal body weight and length decrease with a significant decrease in fetal tail length. Moreover, aspartame induced fetal morphological changes such as body diminution, exencephaly, cognition of the blood vessels in the head region and cleft lips. The skin seemed thin and fragile in the head region as well as the fore and hind regions; hematoma was obvious beside edema, clubbed fore and hind limbs, kyphosis was obvious beside hernias on some regions of the skin with hypertrophy of some fetuses and protrusion of the viscera outside the body. Aspartame exposure at the 2 doses induced highly significant increase in mean of maternal serum AST activity, very highly significant increase in mean serum GGT and serum creatinine activity. Conclusion-Treatment with astaxanthin induced obvious improvement in all of the physiological and morphological changes caused by aspartame in the pregnant rats and their fetuses.  }, keywords = {Aspartame- Astaxanthin,Pregnant albino rats,fetuses,physiology,Teratology}, url = {https://ejhm.journals.ekb.eg/article_15220.html}, eprint = {https://ejhm.journals.ekb.eg/article_15220_389921ccf052101470919f37c0624d7c.pdf} } @article { author = {Helal, Eman G. E. and Gewily, Doaa I. and Al Jalaud, Nora Abdulaziz and Elnemr, Gamal M.}, title = {Effects of Recovery Period and Stem Cell Enhancer on Bisphenol A Treated Female Albino Rats}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {63}, number = {1}, pages = {238-247}, year = {2018}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.12816/0023852}, abstract = {Background: Bisphenol A (BPA) is a worldwide used endocrine disruptor that is incorporated in many plastic industries. Exposure of humans to such substance starts early during the fetal life, postnatal life, and extends throughout the life of the individual. Many agencies raised warnings against excessive use of such substance. Aim of the work: This study aimed to investigate effects of the recovery period (RP) and stem cell enhancer (SCE) on the female albino rats which received BPA. Materials and Methods: This study was performed on forty female albino rats with an average body weight of 140-160 grams. Animals were divided into four groups (10 rats per cage); group I (control untreated for 30 days), group II (BPA treated for 15 days, and then sacrificed), group III (BPA treated first for 15 days, then left for another 15 days without any treatment “RP”), and group IV (BPA treated first for 15 days, then treated with SCE for another 15 days). The following biochemical analyses were done to all groups; ALT (alanine amino-transferase), AST (aspartate amino-transferase), GGT (gamma glutamyl-transferase), total proteins, albumin, globulins, A/G ratio [i.e., liver function tests], creatinine, A/C (albumin/creatinine) ratio, uric acid [i.e., renal function tests], total lipids, total cholesterol, LDL-C (low density lipoprotein cholesterol), HDL-C (high density lipoprotein cholesterol), and triglycerides [i.e., lipids profile]. Results: In the BPA treated rats (group II) the biochemical results showed highly significant increases (P<0.01) in the enzymatic activities of ALT, AST, GGT, creatinine, uric acid, total lipids, total cholesterol, LDL-C, and triglycerides levels, with only a significant increase (P<0.05) in globulins levels when compared to the control group. On the other hand, there was highly significant decreases (P<0.01) in total proteins, albumin, A/G ratio, A/C ratio, and HDL-C levels when compared to the control group. These results turned back to about the normal control values after stopping the use of BPA and either taking a RP (group III) or receiving the SCE (group IV). Conclusions and Recommendations: It could be concluded that BPA has dangerous toxic effects on the liver and kidney functions as well as on the lipids profile. So, we recommend minimizing utilization of this compound (BPA) as possible to protect people from these hazardous effects. Moreover, the RP (i.e., 15 days without treatment) is better than the use of SCE which has no more benefit against the antitoxic effects of BPA.  }, keywords = {BPA,bisphenol A, RP,recovery period, SCE,Stem Cell Enhancer}, url = {https://ejhm.journals.ekb.eg/article_15222.html}, eprint = {https://ejhm.journals.ekb.eg/article_15222_cedef3b99ed9a8df63d6ddd8cde7cb55.pdf} } @article { author = {Helal, Eman G. E. and El sayed, Rasha A. A. and Abu-Taleb, Hoda M.}, title = {The Potential Protective Effect of Stem Cell Enhancer on Chronic Bisphenol-A Treated Female Albino Rats}, journal = {The Egyptian Journal of Hospital Medicine}, volume = {63}, number = {1}, pages = {248-257}, year = {2018}, publisher = {Pan Arab League of Continuous Medical Education}, issn = {1687-2002}, eissn = {2090-7125}, doi = {10.12816/0023853}, abstract = {Background: The xenoestrogen, bisphenol-A (BPA), is a worldwide food contaminant with endocrine disruptor activity that is incorporated in many plastic industries. The exposure of humans to such substances starts early during the fetal life, postnatal life and extends throughout the life of the individual. Many agencies raised warnings against the excessive use of these substances. Aim of the work: The present study was designed to determine if the usage of stem cell enhancer (SE) moderates the physiological changes occasioned by exposure to BPA in the female albino rats. Materials and Methods: This study was performed on thirty female albino rats with an average 100-120 g body weight. The animals were divided into three groups; Group I (Control untreated-group), Group II (bisphenol–A treated group) and Group III (treated group orally supplied with bisphenol –A then treated with stem cell Enhancer (SE)). Serum was separated and used for estimation of hormonal levels [estradiol, progesterone, prolactin (PRL), follicle-stimulating hormone (FSH) and luteinizing hormone (LH)], some biochemical parameters (liver enzymes, kidney function, glucose and lipid profile) and CA-125 and CA 15-3 tumor markers. Results: The biochemical results showed marked significant increase (P<0.01) in the enzyme activities [aspartate aminotransferase (ASAT), alanine aminotransferase (ALAT) and alkaline phosphatase (ALP)],urea and creatinine in bisphenol–A  treated group when compared to the control group. These parameters were significantly reduced in the group treated with stem cell enhancer as compared to bisphenol –A treated group . Decline in the concentration of lipid profile with increase in high density lipoprotein cholesterol (HDL- C) levels in the stem cell treated group as compared to bisphenol-A group were observed. There was a significant elevation in prolactin, FSH and tumor marker levels concomitant with a significant reduction in LH levels in bisphenol-A treated group compared to the control group. These results were changed to values very close to control by using the stem cell enhancer. Conclusion: It could be concluded that bisphenol-A has dangerous effects on liver and kidney functions as well as on lipid profile, female hormones and tumor markers level. So, we recommended minimizing the utililizing of this compound and the use of some protective materials as stem cell enhancer to protect people from its hazardous effects.    }, keywords = {BPA ( bisphenol- A),Stem Cell Enhancer,tumor markers,kidney and liver function tests}, url = {https://ejhm.journals.ekb.eg/article_15223.html}, eprint = {https://ejhm.journals.ekb.eg/article_15223_27e5cc3f7d91dfb788aa265a9c2bfb5a.pdf} }