Non-Polio Enteroviruses Aseptic Meningitis:Embaba Fever Hospital Admissions 2010-2011
Raafat A.
Abdel-Twab
Microbiology Department,faculty of medicine,al-Azhar university
author
Kouka S.
Abdel-Wahab
Microbiology Department,faculty of medicine,al-Azhar university
author
Ahmed O.
El-Kafrawi
Microbiology Department,faculty of medicine,al-Azhar university
author
Moustafa A.
Aly
Microbiology Department,faculty of medicine,al-Azhar university
author
Laila A.
EL-Bassiony
Microbiology Department,faculty of medicine,al-Azhar university
author
May
EL-Maamoun
Microbiology Department,faculty of medicine,al-Azhar university
author
Caroline
Fayez
Microbiology Department,faculty of medicine,al-Azhar university
author
text
article
2013
eng
Human enteroviruses (EV) cause a wide spectrum of both common and uncommon illnesses among all age groups. Enterically transmitted. The objective of this study was to identify non-poliovirus EV as a cause of viral aseptic meningitis (VAM) by two methods (cell culture and Real time PCR). From October 2010 to August 2011 cerebrospinal fluid (CSF) samples were collected from 85 patients Embaba fever hospital admitted with symptoms of aseptic meningitis of any age and both sexes. The 85 CSF samples were inoculated into RD (human rhabdomyosarcoma) cell line in three blind passages to amplify isolates producing EV-like CPE. A total of 14 (16.5%) out of 85 CSF samples showed EV-like CPE. By Real time PCR 11 out of the 14 culture positive samples and 5 out of the 14 source of virus isolation original CSF were non polio EV positive. The frequency of non-polio EV meningitis hospital admissions was in the summer season (50%), spring (25%), late autumn (16.6%) and least frequency in winter (8.4%). non-polio EV meningitis was detected in 6 out of 41 male patients (14.5%) and in 6 out of 44 female patients (13.5%). Also non-polio EV meningitis was detected in all ages with marked increase of incidence in young children (41.6%) and old age (50%) and less in adult (8.4%).
.
In conclusion
Our data showed that the non-polioviruses EV was associated with the majority of VAM during 2010 – 2011 at the Embaba fever hospital which serves Embaba, Shoubra Elkheema, Qualyba and neighbors localities in Egypt. Rapid detection of non-polio EV meningitis is essential for making decisions about patient management and treatment.
The Egyptian Journal of Hospital Medicine
Pan Arab League of Continuous Medical Education
1687-2002
52
v.
1
no.
2013
486
492
https://ejhm.journals.ekb.eg/article_15910_c45c418dd49df5cbd367d289d49352c9.pdf
dx.doi.org/10.12816/0000585
Assessment of Nutritional Status among Preparatory School Girls in Talkha City
Abd El-Rahman
S. I
Community health nursing faculty of nursing zagazig university-Egypt
author
Aly Hassan
S. A
Community health nursing faculty of nursing zagazig university-Egypt
author
EL-Bastawesy
S.I
Community health nursing faculty of nursing zagazig university-Egypt
author
text
article
2013
eng
Background: Adolescence is the period of transition from childhood to adulthood, and it occupies a crucial position in the human life. Nutrition for adolescents is important in which there was found changes in growth and hormones, activity, and food intake.
The objective of the work: was to assess the nutritional status of preparatory school girls in Talkha city.
Patients and methods: a descriptive cross- sectional study on a group of 500 students from the second and third year of the preparatory school girls at Talkha City in Dakahlia governorate , the tools used : 1- A self-administered questionnaire for assessing socio-demographic characteristics of students, anthropometric measurements included weight and height, nutritional health problems, assessing dietary knowledge, and eating habits.2 - An observational checklist to observe signs of malnutrition for the students.
Results: majority of students, girls aged from 13- 14 years old and their mothers were house wife (69.6% &77.3%) , Only less than half studied sample has correct knowledge about the balanced diet, the components of healthy diet, and the effect of healthy balanced diet on individual’s health (34.6 %&20%&78.4%) respectively. Majority of students prefer eating food during watching TV., eating spices and salty food, and eating much candies (76.2% &74.6%& 73.6%) respectively. The most common health problems were headache, GIT problems and dental decay respectively. Conclusion: only one quarter of the studied sample had correct and complete answers about balanced diet. The present study recommended that, health education for nutrition and healthy balanced diet should be integrated in the curriculum of preparatory school girls. Nurses and medical staff must play a significant role in screening, teaching, and guiding of adolescents about healthy balanced diet.
The Egyptian Journal of Hospital Medicine
Pan Arab League of Continuous Medical Education
1687-2002
52
v.
1
no.
2013
493
505
https://ejhm.journals.ekb.eg/article_15912_bde687cae4c9f0e70fcfb7a091a69ef6.pdf
dx.doi.org/10.12816/0000586
Role of Diffusion Weighted Magnetic Resonance Imaging in Evaluation of Suspicious Breast Lesions
Marwa E
Abdelrahman
Departments of Radiodiagnosis Ain Shams University
author
Aida M
Elshibiny
Departments of Radiodiagnosis Ain Shams University.
author
Marwa I
Fahmy
Departments of Radiodiagnosis Ain Shams University.
author
Ahmed F
Abdelghany
Departments of Radiodiagnosis Ain Shams University.
author
Mohamed
Elshinawy
General Surgery, Ain Shams University
author
text
article
2013
eng
Introduction: Diffusion weighted Imaging“DWI”is a specific modality to produce images of tissues weighted with the local microstructural characteristics of water diffusion. DWI can give information as regards cellularity of breast lesions and it can be used for distinguishing between benign and malignant breast lesions, differentiating surgical scar from recurrence and monitoring therapies in locally advanced breast cancer
Aim of the work: To assess the diagnostic value of diffusion weighted imaging as an adjuvant to breast magnetic resonance imaging for detection and differentiation of suspicious breast lesions and correlation with histopathologic findings, available clinical data or follow up.
Methods: The studied group included 50 female patients referred for MRI breast for workup of a suspicious clinical, mammographic, or sonographic abnormality. Diffusion weighted imaging (DWI) was added to the routine study. Results of the contrast enhanced bilateral breast MRI and DWI of the 50 patients were all reported and compared with the histo-pathological results of surgery or biopsy and with the results of follow up of lesions that were not surgically removed or biopsied.
Results: there was a highly significant relation between DWI and histopathological/ Follow Up results with p value = 0.000. The sensitivity, specificity, positive and negative predictive values of DWI for characterization of suspicious breast lesions in patients included in the study, were 89.5%, 100%, 100%, and 93.94% respectively.
Conclusion: DWI is a short unenhanced scan that can be inserted easily into standard clinical breast MRI protocols as a potential adjunct that can be added routinely to conventional breast MRI, and can accurately differentiate benign from malignant breast lesions with high sensitivity and specificity.
The Egyptian Journal of Hospital Medicine
Pan Arab League of Continuous Medical Education
1687-2002
52
v.
1
no.
2013
506
514
https://ejhm.journals.ekb.eg/article_15915_64732feebb107b730bfa2610a5196583.pdf
dx.doi.org/10.12816/0000587
Role of Peritoneal Ports for Treatment of Intractable Ascites
Haytham M
Nasser
Departments of Radiodiagnosis andOncology, Faculty of Medicine, Ain Shams University
author
Maha M
Abd El Raoof
Departments of Radiodiagnosis andOncology, Faculty of Medicine, Ain Shams University
author
Maha K
Abd El Ghafar
Departments of Radiodiagnosis andOncology, Faculty of Medicine, Ain Shams University
author
Mohamed Y
Mostafa
Departments of Radiodiagnosis andOncology, Faculty of Medicine, Ain Shams University
author
Mohamed Sobhi
Hassan
Departments of Radiodiagnosis andOncology, Faculty of Medicine, Ain Shams University
author
text
article
2013
eng
Introduction: Ascites is a common complication of advanced malignancies and cirrhosis. Symptoms of marked abdominal distention, shortness of breath, diminished appetite, fatigue, and lower-extremity edema can significantly compromise a patient’s everyday life. Treatment options for intractable ascites include serial paracentesis, peritoneovenous shunting, transjugular intrahepatic portosystemic shunt (TIPS) creation, and tunneled peritoneal catheters that may be external or, more recently, attached to subcutaneous ports. It is therefore appropriate to evaluate a port specifically designed for peritoneal access as a mean of controlling intractable ascites. We present a minimally invasive treatment for palliative drainage of symptomatic ascites in patients with advanced malignancy.
Aim of the work: The aim of this work is to evaluate the percutaneous implantable access system specifically designed for peritoneal access as a method to control intractable ascites as regards complications and patency.
Methods: This is a prospective intervention study will be conducted on 40 patients with intractable ascites referred from the oncology clinic to the diagnostic imaging department for percutaneous placement of peritoneal portcath as a palliative treatment for the patient.
Results: Good technical success rate (100%) in insertion was found with removal of ascites gradually. Immediate relief of symptoms (100%). There were no major complications. There was one minor complication(2.5%), a leakage at the port placement site in a patient with pancreatic carcinoma. The leakage stopped spontaneous with removal of ascites and the patient underwent conservative management.
Conclusion: peritoneal port systems for treatment intractable ascites is efficient way to avoid ascites related morbidity with increases patient compliance, satisfaction by decreased hospital visits as the drainage and patients monitor can be done in their homes. Port aspiration can be performed in some cases by patients or family members without nursing assistance. In comparison with tunneled peritoneal catheters with external components, the complication rate appears to be minimal.
The Egyptian Journal of Hospital Medicine
Pan Arab League of Continuous Medical Education
1687-2002
52
v.
1
no.
2013
515
521
https://ejhm.journals.ekb.eg/article_15917_92314d3d25a97663ef9ff0f7d80aaaf2.pdf
dx.doi.org/10.12816/0000588
Role of Multidetector Computed Tomography In The Diagnosis Of Congenital Thoracic Vascular Anomalies
Sahar M
El Fiky
Department of Radio-diagnosis, Faculty of Medicine, Ain shams University
author
Hanan M
Hanafy
Department of Radio-diagnosis, Faculty of Medicine, Ain shams University
author
Mohammed S
Hassan
Department of Radio-diagnosis, Faculty of Medicine, Ain shams University
author
Mostafa M
Mansour
Department of Radio-diagnosis, Faculty of Medicine, Ain shams University
author
text
article
2013
eng
Introduction & purpose: Congenital vascular anomalies of the thorax represent an important group of entities that can occur either in isolation or in association with different forms of congenital heart diseases. CT scan is a non invasive & rapid technique used for evaluation of the pediatric vascular disease as an alternative to conventional angiography. Purpose: To assess the role of MDCT scan in evaluation and its ability to diagnose congenital thoracic vascular anomalies as well as to recognize these anomalies early for proper treatment and post operative follow up.
Subjective & Methods: The studied group included 80 patients, who underwent MDCT angiography and had diagnosed of congenital thoracic vascular anomalies, post operative follow up or asymptomatic (incidentally discovered) were included in this study.
Results: CT angiography can diagnosis about 13% (n=6) of cases not seen very well by echocardiography (inconclusive) and 26% (n=12) of cases appear as different findings by CT scan than echocardiography. Three dimensions (3D) images allow excellent display of vascular anomalies that can be used as a vascular road map by surgeons.
Conclusion: MDCT provides reliable diagnostic information on the normal anatomy of the aorta, pulmonary & vena cava as well as congenital anomalies in pediatric and adult patients. MPR and 3D VR images have increased the diagnostic value of CT. Furthermore, coronal and sagittal views of the vessels facilitate the orientation of a surgeon, and thus aid in planning surgery.
The Egyptian Journal of Hospital Medicine
Pan Arab League of Continuous Medical Education
1687-2002
52
v.
1
no.
2013
522
533
https://ejhm.journals.ekb.eg/article_15918_9467e80aea0e6f944c20e3e8f8eed474.pdf
dx.doi.org/10.12816/0000589
Role Guided Intraperitoneal Port-A-Cath Insertion in The Managment of Cancer Ovary of Fluoroscopic
Ahmed H
Soliman
Departments of Radiodiagnosis , Gynecological Oncology Ain Shams University
author
Saad Ali
Abd-Rabou
Departments of Radiodiagnosis , Gynecological Oncology Ain Shams University
author
Maged
Abou Seada
Departments of Radiodiagnosis , Gynecological Oncology Ain Shams University
author
Hesham Ahmed
El-Ghazaly
Departments of Radiodiagnosis , Gynecological Oncology Ain Shams University
author
Mohamed Sobhy
Hassan
Departments of Radiodiagnosis , Gynecological Oncology Ain Shams University
author
Amr Mahmoud
Abdel-Samad
Departments of Radiodiagnosis , Gynecological Oncology Ain Shams University
author
Mohsen Gomaa
El-Sharkawy
Oncology, Faculty of Medicine, Ain Shams University.
author
text
article
2013
eng
Abstract
Introduction :
The use of intraperitoneal (IP) chemotherapy as a treatment for ovarian cancer has been demonstrated to result in improved survival.
Aim of the work: The aim of this work is to evaluate the applicability and efficacy of fluoroscopic placed intraperitoneal port-A-cath and to assess the response rate to intraperitoneal chemotherapy in cases of ovarian carcinoma .
Methods: The studied group included ,22 female patients with malignant ovarian cancer whom referred from gynecological surgery and gynecological oncology units to the Vascular and Interventional Radiology Unit, Ain Shams University Hospitals, for peritoneal port-A-cath application. All the patients were known cases of either primary or recurrent ovarian cancer , underwent cytoreductive surgery and referred to us .
Results: Intraperitoneal port-A-cath with the aid of fluoroscopy showed highest technical success ( 91.9% ) and lowest complication rate on the long run compared to other methods of peritoneal access .
Patients with cancer ovary showed significant improvement of the disease process denoted by changes in the degree of ascites , peritoneal nodules and tumor marker level after receiving combined IV/ IP chemotherapy.
Conclusion: Port catheters proved to be the most safe method of long term access to the peritoneal cavity with the lowest complication rate compared to other methods of access to the peritoneal cavity.
The Egyptian Journal of Hospital Medicine
Pan Arab League of Continuous Medical Education
1687-2002
52
v.
1
no.
2013
534
543
https://ejhm.journals.ekb.eg/article_15919_d6e61bfc6a825ad539d8d55c7350408f.pdf
dx.doi.org/10.12816/0000590
Role of Multislice Dental CT in Assessment of Dental Implants
Safa A
Elaty
Department of Radiodiagnosis: Faculty of Medicine, Ain Shams University
author
Ahmed M
Monib
Department of Radiodiagnosis: Faculty of Medicine, Ain Shams University
author
Yasser A
Mohamed
Department of Radiodiagnosis: Faculty of Medicine, Ain Shams University
author
Ahmed F
Abd elghany
Department of Radiodiagnosis: Faculty of Medicine, Ain Shams University
author
text
article
2013
eng
Introduction: The use of dental implants to restore missing teeth has become increasingly widespread over the past two decades. Dental MSCT plays an important role in the preoperative planning of dental implants because it provides accurate measurement of the width and depth of the edentulous ridge as well as the bone density. And postoperatively, dental MSCT images can show the failure of an endosseous implant to osseointegrate, improper placement of an implant, and violation of important structures.
Aim of the work: Is to determine the success of dental implants following pre-operative multi-slice dental CT planning and for early detection of post-operative complications.
Methods: The study included 25 patients that were divided in to 2 groups, Group I included 14 partially edentulous patients who underwent pre and post- operative dental MSCT, while group II included 11patients that already have dental implants and underwent post-operative dental MSCT using16-slice helical CT scanner.
Results: There is highly significant (P < 0.001) relation between preoperative dental MSCT assessment and postoperative results and dental MSCT was very accurate in the evaluation of osseointegration and very sensitive in the detection of postoperative complications.
Conclusion: Dental MSCT is a promising method that can be used as an imaging tool in the preoperative planning and postoperative assessment of dental implants.
The Egyptian Journal of Hospital Medicine
Pan Arab League of Continuous Medical Education
1687-2002
52
v.
1
no.
2013
544
554
https://ejhm.journals.ekb.eg/article_15920_ad5a233f822a27bac169fe96c19a0578.pdf
dx.doi.org/10.12816/0000591
Clinical Significance of TGF Alpha, TGF Beta1 and VEGF in Sera of Egyptian Patients with Breast Cancer
Motawa E.
El Husseini
Cancer Biology Department, National Cancer Institute, Cairo University
author
Fatmaelzahraa Hussein
Elewa
Faculty of Science, Zoology Department, Mansoura University
author
Abdelghani
M.
Surgical Oncology Department, National Cancer Institute, Cairo University
author
Basma Abdelghany
M
Faculty of Science, Zoology Department, Cairo University, Egypt
author
text
article
2013
eng
Background: breast cancer (BC) is the most prevalent cancer among women and affects approximately one million women worldwide each year and it is the most prevalent cancer among Egyptian women and constitutes 29% of National Cancer Institute cases. This study was designed to determine the crucial role of TGF-α, TGF-β1 and VEGF in patients with Breast carcinoma. Patients & method: serum level of TGF-α, TGF-β1 and VEGF were determined by ELISA in 51 patients with preoperative & postoperative primary (BC), as well as 30 healthy female persons. Results: this study showed that the TGF-α, TGF-β1 and VEGF levels were significantly high (p = 0.001) in patients with primary breast cancer compared to control healthy female group. Meanwhile the levels of these growth factors did show significant decrease after treatment. Conclusion: this study revealed that serum levels of TGF-α, TGF-β1 and VEGF in patients with breast cancer could be useful biomarkers for prognosis of such type of malignancy.
The Egyptian Journal of Hospital Medicine
Pan Arab League of Continuous Medical Education
1687-2002
52
v.
1
no.
2013
555
565
https://ejhm.journals.ekb.eg/article_15921_4abdc8d2b76d33bb5a4b57d3a07033d7.pdf
dx.doi.org/10.12816/0000592
Relation Between Frailty and Common Geriatric Problems in Elderly
Moatassem S
Amer
Geriatrics and Gerontology department, Faculty of Medicine, Ain shams university, Cairo, Egypt,
author
Sarah A
Hamza
Geriatrics and Gerontology department, Faculty of Medicine, Ain shams university, Cairo, Egypt,
author
Tamer M
Farid
Geriatrics and Gerontology department, Faculty of Medicine, Ain shams university, Cairo, Egypt,
author
Samia A
AbdelRahman
Geriatrics and Gerontology department, Faculty of Medicine, Ain shams university, Cairo, Egypt,
author
Hoda M
Farid
Geriatrics and Gerontology department, Faculty of Medicine, Ain shams university, Cairo, Egypt,
author
Heba G
Saber
Geriatrics and Gerontology department, Faculty of Medicine, Ain shams university, Cairo, Egypt,
author
Enas R
Mohamed
Geriatrics and Gerontology department, Faculty of Medicine, Ain shams university, Cairo, Egypt,
author
Randa A
Mabrouk
Clinical Pathology department, Faculty of Medicine, Ain shams university, Cairo, Egypt
author
text
article
2013
eng
Background: There is a high prevalence of common geriatric problems (falls, urinary incontinence, visual and hearing impairment) among frail elderly leading to more disability and functional impairment.
Objectives: The aim of this study is to compare the prevalence of common geriatric problems between frail and non-frail elderly.
Design: A Case control study. Participants: 90 participants aged 60 years and above. They were selected from Ain Shams University Hospital from inpatient wards and outpatient clinics. The studied sample was divided into 2 groups: Group A (30 frail elderly females and 30 frail elderly males) and Group B (30 healthy elderly subjects; 15 males and 15 females).Measurements: Comprehensive geriatric assessment, including detailed history of common geriatric problems as mentioned above, physical examination, and also assessment of frailty using modified Fried criteria ].
Results: Hearing impairment, incontinence and falls were more prevalent in frail elderly with a highly difference between the two groups, with p values< (0.001,0.009,0.006) consequently, visual impairment was statistically significant in cases more than controls with p value (0.012).
Conclusion: There is a significant positive relationship and high prevalence of common geriatric problems especially falls, urinary incontinence, visual and hearing impairment among frail elderly.
The Egyptian Journal of Hospital Medicine
Pan Arab League of Continuous Medical Education
1687-2002
52
v.
1
no.
2013
566
572
https://ejhm.journals.ekb.eg/article_15923_990da06ed0977633882fc3cf8f4f054a.pdf
dx.doi.org/10.12816/0000593
Mobile Phone Radiation Induced Plasma Protein Alterations And Eye Pathology In Newly Born Mice
F.
Eid
Zoology Department, Faculty of Science for Girls, Al-Azhar University, Cairo, Egypt
author
A.
El-Dahshan
Zoology Department, Faculty of Science for Girls, Al-Azhar University, Cairo, Egypt
author
M.
Abou Zeid
Zoology Department, Faculty of Science, Al-Azhar University, Cairo, Egypt.
author
N
Hanafi
Radiation Biology Department, National Centre for Radiation Research and Technology (NCRRT), Atomic Energy Authority (AEA), Cairo, Egypt.
author
text
article
2013
eng
Abstract: The hazardous health effect of the exposure to 900-1800 MHz radiofrequency electromagnetic fields (RF-EMF) which emitted from mobile phones was investigated on the plasma protein and eye of newly born mice. Twenty one newly born mice were divided into 3 groups, the 1st group served as control, the 2nd group exposed to mobile phone radiation daily for one month (45 min/day) and the 3rd group remained one month following the end of exposure. The results showed deleterious changes in the plasma protein pattern by electrophoretic analysis. Also, the microscopic examination demonstrated numerous histopathological and histochemical changes in the eye mainly represented by degenerated, hemorrhagic areas and detachment in some layers of the eye with alteration in collagen, polysaccharides, total protein and marked increase in amyloid beta (β) protein contents of newly born mice exposed to RF-EMF from mobile phone (45 min/day) for one month as well as after one month following the end of exposure. It was concluded that the exposure to mobile phone radiation causes plasma proteins alterations and eye pathology in newly born mice.
The Egyptian Journal of Hospital Medicine
Pan Arab League of Continuous Medical Education
1687-2002
52
v.
1
no.
2013
573
593
https://ejhm.journals.ekb.eg/article_15924_5f30ee0ac9764a643c6aa8f828d40be8.pdf
dx.doi.org/10.12816/0000594
Fixation of Undisplaced Fractures of the Neck of Femur with Multiple Cannulated Screws.
Abdullah Ali
Al-Zahrany
Department of Orthopedics, Taif University, Saudi Arabia
author
text
article
2013
eng
Background and aim of the work: Treatment of fracture neck of the femur varies according to patient’s age and the pattern of the fracture. Multiple cannulated screws (MCS) have been commonly used to treat femoral neck fractures. In this retrospective study we evaluated the outcome of the use of this technique in the treatment of undisplaced fracture neck of femur.
Material and method: In this retrospective chart review study, we revised the files and medical records of the cases of stable fracture neck of femur which had been treated by MCS in patients who were admitted to King Abdul Aziz Specialist Hospital and King Faisal Hospital, Al Taif, Saudi Arabia from January 2007 to December 2011.
Results: Sixteen patients with impacted and undisplaced fracture of the neck of femur were treated with multiple cannulated screws. The mean follow up was 26 months; mean age was 38 years (range 14-58 years). Thirteen/16 patients (81.25%) were satisfied with the excellent results of the treatment. Two patients (12.5%) showed non- union and valgus osteotomy, compression of the fracture and rigid internal fixation were used to promote union. One case developed avascular necrosis and treated by total hip Arthroplasty.
Conclusion: Fixation with cannulated screws usually is adequate for most femoral neck fractures specially the undisplaced type with acceptably low incidence of complications.
The Egyptian Journal of Hospital Medicine
Pan Arab League of Continuous Medical Education
1687-2002
52
v.
1
no.
2013
594
598
https://ejhm.journals.ekb.eg/article_15925_575cbf1d2e06ae86da8ef45bed208f75.pdf
dx.doi.org/10.12816/0000595
The Protective Value of Hesperidin in Mitigating the Biochemical Perturbations and Trace Element alterations induced by Acrylonitrile in Rats.
N. M.
Abdallah
Department of Biochemistry, Faculty of Science, Ain Shams University
author
M. R.
Mohamed
Department of Biochemistry, Faculty of Science, Ain Shams University
author
N. E.
Amien
Department of Drug Radiation Research, National Center for Radiation Research and Technology, Atomic Energy Authority.
author
A. S.
Nada
Department of Drug Radiation Research, National Center for Radiation Research and Technology, Atomic Energy Authority.
author
M. A.
Mohamed
Department of Drug Radiation Research, National Center for Radiation Research and Technology, Atomic Energy Authority.
author
text
article
2013
eng
Objective: Acrylonitrile (a chemical pollutant) has been reported to induce harmful effects in humans. Therefore, this study was designed to evaluate the protective effects of hesperidin, a natural bioflavonoid, against the toxicity induced by acrylonitrile (AN) in rats. Material&Methods: This study includes determination of serum total scavenger capacity “TSC”, liver enzymes (aspartate transaminase “ASAT”, alanine transaminase “ALAT” and alkaline phosphatase “ALP”), total proteins, albumin, glucose, creatinine, urea and lipid profile. Moreover, liver and kidney homogenate glutathione content “GSH”, catalase, superoxide dismutase “SOD”, glutathione peroxidase “GPx”, malondialdehyde “MDA” and some minerals were estimated.
Results: revealed that administration of AN (orally 50mg/ kg b.wt.) induced alterations in TSC level as well as liver, kidney and lipid profiles. In addition, a decrease in GSH-content and catalase, SOD and GPx activities was observed with an increase in MDA levels in both liver and kidney. There was disturbance in certain minerals such as Cu, Zn, Fe, Se, Ca, Mg and Mn. Conclusion: particularly, Hesperidin administration (orally 200 mg/kg b.wt.) ameliorates the oxidative stress induced by AN, consistent with the reported antioxidant activity of hesperidin.
The Egyptian Journal of Hospital Medicine
Pan Arab League of Continuous Medical Education
1687-2002
52
v.
1
no.
2013
599
607
https://ejhm.journals.ekb.eg/article_15926_cc42a921b42824f60ff2da4394ccdaef.pdf
dx.doi.org/10.12816/0000596
Uric Acid Metabolism in a Sample of Egyptian Hypertensive Patients With Normal Kidney Function
Adel
Afifi
Nephrology department, Ain Shams University
author
Iman
Sarhan
Nephrology department, Ain Shams University
author
Magdy
El Sharkawy
Nephrology department, Ain Shams University
author
Mostafa
Kamel
Nephrology department, Ain Shams University
author
Waleed
Anwar
Nephrology department, Ain Shams University
author
Nermine
Helmy
Clinical and Chemical pathology department, Ain Shams University
author
Shereen
Omar
Electricity hospital
author
text
article
2013
eng
Background: Hyperuricemia is commonly associated with hypertension. Also, it is well known to coincide with the metabolic syndrome but is still not recognized as a risk factor. So, we aimed to evaluate hyperuricemia among a sample of hypertensive Egyptians with normal renal function.
Methods: this study was performed on 303 hypertensive patients aged 30-69 years. Patients were divided into 2 groups according to the level of uric acid: group 1 composed of 168 hypertensive hyperuricemic patient sand group2 composed of 135 hypertensive normouricemic patients. All patients were subjected to complete medical history and detailed clinical examination including body mass index (BMI), complete blood count (CBC), serum creatinine, BUN, FBS, cholesterol, triglycerides, uric acid, sodium, potassium, urinary uric acid, urinary creatinine, urinary uric acid to creatinine ratio and fractional excretion of uric acid(FEUA).
Results: The overall prevalence of hyperuricemia was 55.4%. Uric acid correlated significantly with age (p<0.05). BMI was significantly higher in group1 than in group 2(p<0.05), and there was a significant positive correlation between serum uric acid and BMI (p<0.01).Serum triglycerides and cholesterol were significantly higher in group 1than in group 2 (p<0.05for both) denoting risky metabolic effects. Serum uric acid correlated significantly with systolic blood pressure (p<0.05), but not with diastolic blood pressure. No significant difference found between group 1 and group 2 as regards SBP, DBP or blood pressure control(all p values>0.05). Serum uric acid found to correlate significantly (p<0.001) with urinary uric acid, urinary creatinine and negatively with FEUA denoting early tubular defect of the kidney. Also, Urinary uric acid, urinary creatinine and urinary uric acid/creatinine ratio were higher in group 1than in group 2 (p values were<0.001, <0.001 and <0.05 respectively). FEUA was found to be significantly lower in group 1 than in group 2 (p<0.01). We found, also, that serum sodium level was significantly higher in the hyperuricemic group than in the normouricemic group (p<0.001) denoting the role of Na+ in the development of hypertension and defective renal excretion of uric acid.
Conclusion: We conclude that the incidence hyperuricemia in our sample of Egyptian hypertensive patients was (55.4%). Impaired renal clearance of uric acid occurs before deterioration of GFR. Serum uric acid should be measured in all cases of hypertension together with BMI, total cholesterol, triglycerides and should be treated to avoid consequent metabolic complications. Hypertensive patients with hyperuricemia should be warned strictly of high sodium diet.
The Egyptian Journal of Hospital Medicine
Pan Arab League of Continuous Medical Education
1687-2002
52
v.
1
no.
2013
608
614
https://ejhm.journals.ekb.eg/article_15927_53d62560021aea57858040c71fb4ee35.pdf
dx.doi.org/10.12816/0000597
Lipid Profile and Some Hormonal Disorders in Serum of High-Fat Diet Fed Rats
Hany Nady
Yousef
Department of Biological and Geological Sciences, Fac. of Education, Ain Shams University
author
Afaf Abbass
Saleh
Zoology department, Women's college, Ain Shams University
author
text
article
2013
eng
Background: Chronic consumption of high-fat diet (HFD) induces obesity. The purpose of the current study was to evaluate the impact of high-fat diet-induced obesity on lipid profile and levels of certain hormones in male albino rats.
Material and Methods: A total of forty two 12-week old male albino rats were divided into three groups: control group fed a normal diet, obese group I fed 25% HFD and obese group II fed 50% HFD. Each group was divided into two subgroups (seven rats for each) feeding on the corresponding diet for four and eight weeks. Serum total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-Chol), low density lipoprotein cholesterol (LDL-Chol), free Triiodothyronine (FT3), free Thyroxine (FT4), Insulin, Leptin and Adiponectin were assessed at the end of 4th and 8th weeks. Also LDL/HDL-cholesterol ratios of control and obese groups were calculated at the same time intervals.
Results: The obtained results indicated significant increase in all parameters of serum lipid profiles in addition to elevation of the LDL/HDL-cholesterol ratios of obese rats compared to those of the controls. In response to HFD, marked increase was recorded in the levels of insulin and leptin while values of FT3 and adiponectin were reduced significantly. On the other hand, HFD did not change the levels of FT4. Most of the recorded changes were more obvious by increasing either the percentage of fats or the feeding period.
Conclusion: In conclusion, HFD induces some hormonal disorders accompanied by disturbance of the lipid profile.
The Egyptian Journal of Hospital Medicine
Pan Arab League of Continuous Medical Education
1687-2002
52
v.
1
no.
2013
615
623
https://ejhm.journals.ekb.eg/article_15928_48a987c8fd166dd15ae44bc5ecaf3519.pdf
dx.doi.org/10.12816/0000598
Impact of Hyperuricemia on Cardiovascular System in ESRD Patients
Mostafa
Kamel
Internal medicine& Nephrology department, Ain Shams University, Cairo, Egypt
author
Magdy
El-Sharkawy
Internal medicine& Nephrology department, Ain Shams University, Cairo, Egypt
author
Essam
Afifi
Internal medicine& Nephrology department, Ain Shams University, Cairo, Egypt
author
Medhat
Ali
Internal medicine& Nephrology department, Ain Shams University, Cairo, Egypt
author
Ahmed
Ramadan
Internal medicine& Nephrology department, Ain Shams University, Cairo, Egypt
author
text
article
2013
eng
Background: Hyperuricemia was found to be associated with hypertension, coronary heart disease, metabolic syndrome and chronic kidney disease. However there are no specific data about the relationship of uric acid to cardiovascular disease and mortality in ESRD patients on chronic hemodialysis. So, we aimed to study the impact of hyperuricemia on cardiovascular system in chronic kidney disease and in ESRD patients on regular hemodialysis
Patients and methods: This study included 100 patients in Ashmoun hospital, nephrology department. Patients were chosen and divided into two groups: Group A, 50cases with chronic kidney disease and Group B, 50cases of ESRD on regular hemodialysis. All cases were subjected to full clinical examination, measurement of eGFR, laboratory tests for blood urea, serum creatinine and serum uric acid and ECG.
Results: Serum uric acid was significantly higher in dialysis group than CKD group (p<0.01). There was a highly significant correlation between uric acid and both systolic and diastolic blood pressure in Group A (all p values <0.01). Also, there was a significant correlation between serum uric acid and eGFR (p<0.05).No significant difference found between Group A and group B as regards ECG findings (p>0.05).
Conclusion: In cases of CKD uric acid is involved in the pathogenesis of renal failure and hypertension. In patients with ESRD, hyperuricemia is not a risk factor for the development of cardiac disease; but it shows reversed epidemiology and becomes a marker of good nutritious status. Further studies should be done on wider scales to evaluate the impact of hyperuricemia on cardiovascular system in hemodialysis patients.
The Egyptian Journal of Hospital Medicine
Pan Arab League of Continuous Medical Education
1687-2002
52
v.
1
no.
2013
624
629
https://ejhm.journals.ekb.eg/article_15929_f19850eab43e31393fd3d39eb22abf79.pdf
dx.doi.org/10.12816/0000599
Evaluation of the Role of CXCL8 and NOx in Pediatric Type 1Diabetes Mellitus
Ali K
Alzahrani
Department of Pediatrics, Taif University
author
Humaid
Al-Swat
Department of Pediatrics and Neonatology, King Abdul Aziz Specialist Hospital
author
Nihad A
Al Nashar
Department of Pathology, Taif University
author
Hala A
Mohamed
Department of Pathology, Taif University
author
text
article
2013
eng
Background and aim of the work: Genetic and environmental factors may play a role in the etiology of type 1diabetes (T1D) but a well-accepted view is that autoimmunity is the predominant effector.The aim of this study is to investigate the profile and the relationships between interleukin (IL, CXCL) -8 and nitric oxide metabolite (NOx) in T1D and to reveal their possible role in the development and progression of the disease and its complications.
Material and method:Twenty children with Type 1 diabetes (T1D) were enrolled for the study and compared to twenty healthy age and gender matched non-diabetic controls.
Results:The data revealed that children with T1D established high glycated hemoglobin (HbA1c %) values versus the control group (P<0.0001). Significantly higher serum CXCL-8 concentration (23.54±11.92pg/ml) was detected in T1D children versus the control group(5.69±1.67pg/ml). 0n the other hand, serum nitric acid metabolite (NOx) showed a significant reduction in the T1D children (2.38±1.14 mmol/l) compared to the control group (4.63±1.2 mmol/l). Correlation analysis showed positive correlation between CXCL-8 with duration of the diabetes and with HbA1c.
Conclusion: It could be concluded that CXCL-8 and NO may play important roles in the pathophysiology and progression of T1D with increased possibility to develop premature atherosclerosis which should be considered in the development of new strategies for monitoring the disease as well as for developing effective preventive and therapeutic interventions.
The Egyptian Journal of Hospital Medicine
Pan Arab League of Continuous Medical Education
1687-2002
52
v.
1
no.
2013
630
636
https://ejhm.journals.ekb.eg/article_15930_eb3e89957e0b929847f58710f5f15733.pdf
dx.doi.org/10.12816/0000600
Endoscopic Thoracic Sympathectomy: A Comparative Study of Resection And Electro-diathermy Ablation in the Treatment of Primary Palmar Hyperhidrosis, Taif Experience
Mohammed
Al Saeed
Department of Surgery AL Taif University, Saudi Arabia
author
Mohamed
Hatem
Department of Surgery AL Taif University, Saudi Arabia
author
Majed
Al Mourgi
Department of Surgery Al Hada Armed Forces Hospital, Saudi Arabia
author
text
article
2013
eng
Background and aim of the work: Palmar Hyperhidrosis is an excessive and unpleasant sweating and it is under control of the thoracic sympathetic chain. At present, endoscopic upper thoracic Sympathectomy (ETS) offers a safe and durable solution of the condition. The operation includes excision, electro diathermy ablation or application of surgical clips on the thoracic sympathetic ganglia T2 and T3. The present study was done to compare the results achieved by excision and electro-diathermy ablation.
Patients and methods: This prospective randomized study was conducted in King Abdul Aziz Specialist Hospital and Al-Hada Armed Forces Hospital, Taif- Saudi Arabia, from January 2007 to August 2010 and included sixteen patients with primary palmar hyperhidrosis. They were randomized into 2 groups; each of 8 patients. In one group; the sympathetic chains with T2 and T3 ganglia were excised on both sides and in the other group, the sympathetic chains and ganglia were ablated bilaterally using electro-coagulation diathermy hook.
Results: There were 10 women and six men. The mean age of the ablation group was 23.6±7.6 years and in the resection group it was 22.5±8.4years. The mean operating time for bilateral Sympathectomy in the resection group was 74±18.6minutes; whilst in the thermal ablation group it was 32±7.8 minutes. The mean postoperative hospital stay in the excision group was 48±12 hours and in the ablation group, it was24±6 hours. No deaths occurred and all patients are discharged with dry hands. The mean follow up was 24±18 months. Intraoperative intercostal venous bleeding occurred in 18.75% of sympathectomies in the excision group but not in the ablation group. Neuralgic pain of the chest wall developed in 31.25% of sympathectomies of the excision group and 6.25% of the sympathectomies of the ablation group. Horner's syndrome developed in 6.25% per cent of the sympathectomies in both groups. Compensatory hyperhidrosis of trunk and thighs occurred in 37.5% of both groups. Recurrence developed in 6.25% of ablation group but no recurrence in the excision group.
Conclusion: The rate of recurrence after endoscopic thoracic sympathectomy for treatment of primary palmar hyperhydrosis, if ablation is used, may be higher than resection, however; it is practically accepted as the procedure is easier, has shorter operating time with less liability to develop neuralgic pain and intercostal venous bleeding.
The Egyptian Journal of Hospital Medicine
Pan Arab League of Continuous Medical Education
1687-2002
52
v.
1
no.
2013
637
641
https://ejhm.journals.ekb.eg/article_15931_5d8daf81251307c4677f037f966507b8.pdf
dx.doi.org/10.12816/0000601
Prevalence, Pattern of Presentation, Risk Factors and Outcome of Acute Mesenteric Venous Thrombosis in Taif Province, Saudi Arabia, A Single Center Study
Mohamed
Al Saeed
Department of Surgery, Taif University
author
Mohamed
Hatem
Department of Surgery, Taif University
author
Aseel
Abu Duruk
Department of Surgery, Taif University
author
Hala A
Mohamed
Department of Pathology, Taif University
author
Nihad
Al Nashar
Department of Pathology, Taif University
author
Mohamed
Ahmed
Department of Radiology, Jazan University
author
Nesreen
Al Margoushi
Department of Medicine, Taif University
author
text
article
2013
eng
Background and aim of the study: Mesenteric venous thrombosis has a global incidence of 10-15% of all cases of mesenteric ischemia; however reports from high altitude provinces of Saudi Arabia as Taif and Aseer recorded an incidence above 60%. The aim of this study is to record the incidence, pattern of presentation, risk factors; diagnostic tools and outcome of treatment in a single center (King Abdul Aziz Specialist Hospital) Taif, Saudi Arabia.
Material and method: In this retrospective chart review study, we reviewed the records and data of all patients presented to King Abdul Aziz Specialist Hospital, Taif, Saudi Arabia from January 2009 to January 2013 and their final diagnosis were proved to be acute mesenteric venous thrombosis. Traumatic, postoperative and non occlusive cases were excluded from the study.
Results:Sixteen patients with final diagnosis of acute mesenteric venous thrombosis were included in this study, out of 26 patients (61.5%) presented and diagnosed as acute occlusive mesenteric ischemia. Males were more affected than females. The mean age of the patients was 55±13.4 years. The mean duration of symptoms was 4.9±1.4 days.The most common presenting symptoms were; abdominal pain followed by nausea, vomiting, anorexia, bloody diarrhea and fever. The most prevalent physical findings was tachycardia followed by ileus, 5 patients presented by marked peritoneal signs 3 of them were shocked. Multiple risk factors were detected in all patients. Laboratory findings were not conclusive and diagnosis was established by CT angiography in most of the patients. During operation, all patients were found to have a segment of infarction of the small intestine and in one of them the cecum was involved. Resection of the gangrenous parts was done for all patients. Second look operation was performed in 25% of patients. The total mortality was 18.75%.
Conclusion: Acute mesenteric venous thrombosis is the most common cause of acute occlusive mesenteric ischemia in Taif province and this may be related to multiple risk factors. Being familiar with this disease is essential in making the correct diagnosis to be followed by prompt resuscitation with heparinization to be continued postoperatively to prevent recurrent thrombosis. Laparotomy should be performed as soon as metabolic and hemodynamic correction is done with resection of any infracted segment. A second look operation may be required. If these steps are followed strictly and without delay, the prognosis of mesenteric venous thrombosis is often favorable.
The Egyptian Journal of Hospital Medicine
Pan Arab League of Continuous Medical Education
1687-2002
52
v.
1
no.
2013
642
649
https://ejhm.journals.ekb.eg/article_15932_f1a341132f82473608db897cc49c04cf.pdf
dx.doi.org/10.12816/0000602
Characteristics of pregnant Women admitted with 2009 H1N1 Influenza in a referral maternity hospital at Al-Madinah, Saudi Arabia
Inass
Taha
Department of Medicine, College of Medicine, Taibah University, Madinah, Saudi Arabia
author
text
article
2013
eng
Background: To date there has been no study done in Saudi Arabia to identify the risk factors for poor outcome of H1N1 infection in pregnancy.
Objectives: we aimed to evaluate the epidemiological data, clinical course, treatment modalities, and maternal and fetal outcomes of 33 pregnant women diagnosed with H1N1 Influenza A in a referral maternity and children hospital at Al- Madinah Saudi Arabia on the period from June 2009 till February 2010.
Methods: This retrospective cohort study reported 33 pregnant women (9.1% primigravida) aged 27.7±5.6 years who were laboratory-confirmed cases diagnosed with H1N1 Influenza A in a referral maternity and children hospital at Al- Madinah Saudi Arabia on the period from June 2009 till February 2010. Their mean gestation age was 23.5±10.9 weeks with history of bronchial asthma in 45.5%.
Results: The mean duration between symptoms’ onset and hospital presentation was 5.0±2.2 days with late presentation in 10 cases (30,3%). Large number of cases presented with fever more than 39 (24 (72.7%), sore-throat (24 (72.7%) and cough (29 (87.9%) while 19 patients presented with dyspnea (57.6%). Pregnant patients with H1N1 received Tamiflu (oseltamivir)) from 2 to 7 days with a mean of 4.7±1.3 days. They stayed at hospital for variable periods from 2 to 28 days with a mean of 7.9±6.6 days (Table 4). Most patients (31(93.9%)) received antibiotics. Maternal poor outcome included hypoxia in 6 patients (18.2%), ICU admission for 2-3 days with mechanical ventilation in 4(12.1%)). The main fetal poor outcome was intrauterine fetal death in 2 (6.1%) babies .
Conclusion:
The main presentation of H1N1 among pregnant women was typical influenza-like illness. Considerable percentage of patients presented late (30.3%). The duration of hospital admission is variable up to 28 days. Bronchial asthma was prevalent (45.5%) among pregnant women with H1N1 infection. The main poor outcomes were maternal respiratory failure (18.2%) and intrauterine fetal death (6.1%). There is increased risk of intrauterine fetal mortality (6.1%) rather than materanl mortality (0%) .
The Egyptian Journal of Hospital Medicine
Pan Arab League of Continuous Medical Education
1687-2002
52
v.
1
no.
2013
650
657
https://ejhm.journals.ekb.eg/article_15933_eb6bcc43357f050936408c72d539be64.pdf
dx.doi.org/10.12816/0000603
Assessment of Iron Status in Anemic Children with Chronic Kidney Disease
Ali K
Alzahrani
Department of Pediatrics, Taif University, Taif, Saudi Arabia
author
Abdrahman
Alzahrani
Pediatrics' Hospital, Taif, 4Department of Pathology, Taif University
author
Nihad A
Al Nashar
Department of Pathology, Taif University
author
Hala A
Mohamed
Department of Pathology, Taif University
author
text
article
2013
eng
Background: Iron deficiency is the commonest cause of resistance to erythropoiesis stimulating agents (ESAs) in dialyzed children treated from anemia of chronic kidney disease (CKD).
Aim of the work: This study was conducted in order to evaluate the significance of different biomarkers in assessment of iron status during management of anemic children with CKD.
Patients and method: Twenty five children with diagnosis of anemia of chronic kidney disease were enrolled for the study. They were classified into two groups according to their stage of the kidney disease. Group I; included 15 children with anemia of CKD and their Glomerular Filtration Rate (GFR) was 15.5 – 29.6 ml/min/1.73m2 (stages; III & IV CKD) and they were managed conservatively. Group II; It included 10 anemic children with end stage renal disease (Stage V CKD, GFR was 6.1 – 13.7 ml/min/1.73m2) and they were under regular hemodialysis. Another 10 healthy children with matched age and gender served as control group (group III).
Results: The study showed that the hypochromic cell percentage was significantly higher in both groups I and II before treatment when compared to controls (p <0.0001). Serum ferritin showed very high significant elevation in all the studied groups as compared to controls, also group II was highly significant when compared with group I before treatment. Improvement of iron mobilization and metabolism after 8 weeks of therapy with intravenous iron and erythropoietin was evidenced by significant increase in hemoglobin (Hb) level, RBCs and HCT % when comparing the group II patients before and after treatment. Also significant decrease in hypochromic cell percentage and increase in serum ferritin were proved. The sTfR and sTfR/ F indices showed elevation in the post-treatment group.
Conclusion: No single biomarker is reliable alone in the assessment and monitoring the iron status in anemic patients with CKD under ESAs therapy. Measurement of hypochromic cell percentage may be simple and reliable method, and sTfR represents a valuable quantitative assay of marrow erythropoietic activity as well as a marker of tissue iron deficiency. However, the sTfR / Ferritin index is considered to be more efficient in anemic patients with CKD for early prediction of functional iron deficiency and is a sensitive tool for follow up of iron status during ESAs therapy.
The Egyptian Journal of Hospital Medicine
Pan Arab League of Continuous Medical Education
1687-2002
52
v.
1
no.
2013
658
669
https://ejhm.journals.ekb.eg/article_15934_9dbad0cd2bd4ab71c314e1b982b6f85d.pdf
dx.doi.org/10.12816/0000604
Diagnostic and Screening Utility of Biochemical Markers for Osteoporosis and Osteopenia in Saudi Women
Abdullah Ali
Al-Zahrany
Department of Orthopedics Taif University, Saudi Arabia
author
Nihad A.
El-Nashar
Department of Pathology
Taif University, Saudi Arabia
author
Hala A.
Mohamed
Department of Pathology
Taif University, Saudi Arabia
author
text
article
2013
eng
Background and aim of the work: Postmenopausal osteoporosis is a major health problem worldwide and in Saudi Arabia as it leads to bone fragility and increased liability for fragile fractures, particularly in neck of femur and vertebrae. The present study was designed to determine the value of different screening tests to find out the most sensitive serum and urinary markers of osteoporosis among Saudi women and to clarify the relationship between E2 deficiency and these markers in peri-menopause, early or postmenopausal women without hormonal replacement therapy.
Material and methods: This study included 37 Saudi women aged 40 to 60 years. They were categorized into 3 groups according to their bone mineral density (BMD): Group I: 15 Normal control (T-score up to -1.5), Group II: 12 Osteopenic women ( T-score between –1.5 to –2.5)and Group III:10 Osteoporotic women ( T-score below –2.5). For all subjects, dual energy X-ray absorptiometry (DEXA) was performed. Osteocalcin (OC), alkaline phosphatase (ALP), free galactosyl hydroxylysine (Gal-Hyl), calcium (Ca), inorganic phosphorus (P) and estradiol (E2) were measured in serum, whereas, deoxypyridinoline (Dpd) and creatinine levels were measured in urine.
Results: Simultaneously both osteopenic and osteoporotic groups showed significant decreases in BMD when compared to the controls. Osteocalcin, ALP and Gal-Hyl showed significant increase (p<0.0001) among the osteopenic and osteoporotic groups versus the control group. Significant decrease in E2 levels were obvious among the osteopenic (p<0.0001) and osteoporotic (p<0.0001) women when judged against the controls. Urinary Dpd was significantly increased in the osteopenic and osteoporotic groups (p<0.001). In osteoporotic group, significant negative correlations were observed between OC and BMD. Positive correlations were detected among the osteoporotic group between OC and ALP and between OC and Gal-Hyl. High significant negative correlations were confirmed between E2 and OC among both the osteopenic and the osteoporotic groups. Also, a significant negative correlation was established between E2 and Dpd in the osteoporotic group. In comparing between osteopenic and osteoporotic groups, significant decrease was recognized in BMD and significant increase was predicted regarding ALP, (p<0.05), Gal-Hyl (p<0.0001) and Dpd (p< 0.001).
Conclusion: Urinary Dpd may be a simple indicator for osteoporosis in postmenopausal women; however, screening should include the measurement of serum estradiol, galactosyl hydroxylysine, alkaline phosphatase and Osteocalcin to increase the sensitivity and specificity of primary screening to identify the groups at higher risk of osteoporosis which is the keystone in prevention of disabling fragility fractures.
The Egyptian Journal of Hospital Medicine
Pan Arab League of Continuous Medical Education
1687-2002
52
v.
1
no.
2013
670
677
https://ejhm.journals.ekb.eg/article_15935_343758abe59e6a13f3882890bda7563f.pdf
dx.doi.org/10.12816/0000605
Prevalence of Cervical Cellular Abnormalities by Liquid Based Cytology in Taif Province: A Hospital Based Study
Dalal M
Nemenqani
Department of Pathology, Taif University
author
Hala
Al Nashar
Department of Pathology, Taif University
author
Moemen M
Hafez
Department of Pathology King Abdul Aziz Specialist Hospital, Taif
author
Mohamed
Hatem
Department of Surgery, Taif University
author
Samia, H
Al Malki
College of Medicine, Taif University, KSA
author
Afnan, H
Al Salmi
College of Medicine, Taif University, KSA
author
Sawsan, S
Al Khammash
College of Medicine, Taif University, KSA
author
text
article
2013
eng
Aim of the work: The aim of this study was to determine the prevalence of the cervical cellular Abnormalities using liquid based thin-layer preparations as screening test for women who attended the gynaecology outpatient clinic at King Abdul Aziz Specialist Hospital, Taif, Saudi Arabia.
Material and method: In this retrospective chart review study, we reviewed the records and data of all women for whom liquid base cytological studies were performed as screening test to detect the cervical cellular abnormalities at King Abdul Aziz Specialist Hospital, Taif, Saudi Arabia from June 2010 to June 2012.
Results:The total number of women for whom liquid base, thin-layer cytological studies were performedwas 2168 patients 79.9% of them were symptomatic. The mean age was 38.6 years. Liquid based thin-layer preparations were used for all patients. Cervical abnormality was seen in 25.6% of the patients, of which 6.5% were malignant or premalignant and 19.1% were of benign nature.
Conclusion: Liquid-based, thin-layer cytology reduces sampling and preparation errors of the conventional smear; however, screening should include human papilloma virus (HPV), DNA testing to increase the sensitivity and specificity of primary screening.
The Egyptian Journal of Hospital Medicine
Pan Arab League of Continuous Medical Education
1687-2002
52
v.
1
no.
2013
678
684
https://ejhm.journals.ekb.eg/article_15936_e15d25d2118c7cfe881a7a71a56983eb.pdf
dx.doi.org/10.12816/0000606
Hypoglycemic Effect of the Aqueous Extracts of Lupinus albus, Medicago sativa (Seeds) and Their Mixture on Diabetic Rats
Eman G. E.
Helal
Departments of Zoology – College of Science - Al-Azhar University (Physiology)
author
Samia M.
Abd-Elwahab
Departments of Zoology – College of Science - Al-Azhar University (Histology )
author
Tarek A.
Atia
Applied Medical Sciences - Salman Bin Abdul-Aziz University, KSA
author
Anwaar Alkamel
Mohammad
Department of Medical Science - College of dentistry - Sinai University
author
text
article
2013
eng
Objectives: The number of people suffering diabetes mellitus is increasing worldwide at an alarming rate. A huge number of populations in the world are entirely dependent on traditional medications. This practice may be due to their safety, effectiveness, and availability as well as their fewer side effects when compared to the synthetic hypoglycemic agents. The present study was carried out to investigate and compare the activity of Lupinus albus (seeds), Medicago sativa (seeds) and the mixture of both plants seeds on some biochemical, hematological and histological parameters in alloxan-induced diabetic rats.
Material and method: Twenty-five male adult albino rats were divided into two groups: group 1: control group (five animals) and group 2: alloxan induced diabetic rats. Diabetic rats were further divided into four subgroups, five animals each. Subgroup1: diabetic untreated rats; subgroup 2: diabetic rates treated with aqueous extract of Lupinus albus seeds; subgroup 3: diabetic rats treated with aqueous extract of Medicago sativa seeds; and finally subgroup4: diabetic rats treated with aqueous extract of the mixture of Lupinus albus and Medicago sativa seeds. After thirty days of treatment all rats were sacrificed, blood sample were collected to estimate some biochemical and hematological parameters. Liver samples were collected to determine their glycogen content and pancreatic samples were obtained and processed for microscopic and quantitative evaluation.
Results: In diabetic group, there was reduction in body weight's, hyperglycemia, hypoinsulinemia, significant increase in some parameters of liver and kidney functions as well as significant changes in lipids profile and proteins level with significant decreased liver glycogen content. All treated groups restored most of the mentioned parameters to their normal values. Moreover, these treatments recorded partial improvement in the histopathological changes produced by alloxan.
Conclusion: The aqueous extract of Lupinus albus or Medicago sativa (seeds) or by their mixture has hypoglycemic and hypolipidemic effects by increasing insulin level and decreasing insulin resistance. In addition, they ameliorate most complications of diabetes.
The Egyptian Journal of Hospital Medicine
Pan Arab League of Continuous Medical Education
1687-2002
52
v.
1
no.
2013
685
698
https://ejhm.journals.ekb.eg/article_15937_a59655efe6927e4ee9f1ccc571a572f6.pdf
dx.doi.org/:10.12816/0000607
Role of Multisclice And Virtual Cystoscopy Versus Ultrasound and Color Doppler Study in Evaluation of Urinary Bladder Neoplasms
Hanaa Abdel Kader
Abdel Hamed
Radiodiagnosis Faculty of medicineAin Shams University
author
Rania Aly
Maarouf
Radiodiagnosis Faculty of medicineAin Shams University
author
Togan Taha
Abdel Azez
Radiodiagnosis Faculty of medicineAin Shams University
author
Sameen Shoukry
Sobhey
Radiodiagnosis police authority hospital
author
text
article
2013
eng
Introduction: the virtual cystoscopy and the color Doppler examinations are good modalities in assessment of the urinary bladder neoplasms. This study is done to assess the accuracy of CTVC and color Doppler ultrasound in detection of the urinary bladder neoplasms.
Patients and methods: The examination was done between June 2010 and December 2012 on 60 patients known or suspected to have urinary bladder neoplasm. They were examined using CTVC and color Doppler ultrasound. Bladder scanned using multislice CT at a slice thickness of 1 mm. The data were transferred to a workstation for interactive navigation. Findings obtained from CTVC and ultrasound were compared with results from conventional cystoscopy and with pathological findings.
Results:
By the conventional cystoscopy; the 43 patients in the group A showed 53 lesions. There were (35/43 patients) with single lesion while there were (8/43 patients) more than one lesion. While the other 17 patients in group B showed 11 patient with no focal lesions and 6 patients with 6 focal lesions.
By virtual cystoscopy; 56 lesions were detected in both groups; 51 plus 5 lesions in group A and B respectively. There were 3 false negative lesions with a failure rate of 3/56.
By ultrasound; 56 lesions were detected in both groups; 53 plus 3 lesions respectively.
So in virtual cystoscopy and ultrasound the results were as follows: positive predictive values: 100%; negative predictive value: 78.6 %; sensitivity: 94.9%; specificity: 100%
Conclusion: Although the definitive diagnosis of some suspected urinary bladder tumors is only possible with conventional cystoscopy and biopsy, CTVC and color Doppler ultrasound are a minimally or non-invasive techniques which provide beneficial information about urinary bladder lesions.
The Egyptian Journal of Hospital Medicine
Pan Arab League of Continuous Medical Education
1687-2002
52
v.
1
no.
2013
699
707
https://ejhm.journals.ekb.eg/article_15938_923709ec598f007d7d12183b8f6e5526.pdf
dx.doi.org/10.12816/0000608
The Role of Pre-Operative Magnetic Resonance Mammography In Obese Women With Suspected Breast Cancer
Darine HA
Saad
Radiodiagnosis department, Faculty of Medicine, Ain Shams University
author
Hana H
Nassef
Radiodiagnosis department, Faculty of Medicine, Ain Shams University
author
Sherine K
Amine
Radiodiagnosis department, Faculty of Medicine, Ain Shams University
author
Salwa R
El-Batrawy
Radiodiagnosis department, Faculty of Medicine, Ain Shams University
author
text
article
2013
eng
OBJECTIVE: To high-lighten the role of MR mammography as a pilot pre-operative modality in the staging of breast cancer and its impact on surgical planning and management; aiming to decrease morbidity and mortality of this increasingly spreading cancer. In addition, to clarify the assessment of the relationship between the types of obesity and staging breast cancer. Moreover, to evaluate the diagnostic validity of breast MRI in discriminating benign from malignant lesions in women with suspected breast cancer histopathologic findings used as the golden standard.
PATIENTS AND METHODS: Contrast-enhanced bilateral breast MRI was performed on 60 women with suspected breast cancer with indeterminate imaging findings by mammography and/or ultrasonography. Lesions detected by MRI that could represent potential malignancies in both breasts were evaluated. Morphologic assessment and kinetic analysis (contrast enhancement) were performed on each lesion using dedicated postprocessing and display software. Functional MR tools were used in few cases (6 cases) to help in the differential diagnosis between malignant and benign of suspicious lesions detected at conventional MRI. All patients underwent clinical and radiological evaluation followed by Contrast-enhanced bilateral breast MRI using 1.5-tesla superconductive Philips scanner and General Electric Medical Systems. The diagnostic images were evaluated as regard lesion morphology (size, shape, margin type, enhancement pattern), signal intensity parameters (time to peak enhancement, maximum slope of enhancement curve, washout), and the BIRADS categories. Results of the contrast enhanced bilateral breast MRI of the 60 patients were all reported and compared with the histopathalogical biopsy.
RESULTS: A total of 60 patients presented with suspected breast cancer were included in the study with age ranging from 38 to 75 years old. 22 of the studied population had benign findings, while 38 of the patients were diagnosed as malignant. (18 patients IDC, 6 patients Invasive Lobular Carcinoma, 3 patient Mucinous carcinoma, no patients Medullary carcinoma and 4 patients Insitu cancer). In this study population the sensitivity, specificity, positive and negative predictive values of mammography were found to be 51.6%, 88.4%, 66.7%, and 80.3% respectively. Overall accuracy of mammography was 77%. Among the 38 cases diagnosed by sonomammography as malignant or with irregular densities, 16 turned out to be benign by histopathological evaluation (false +ve), while among the 22 cases diagnosed by sonomammography to be benign lesions or non-conclusive studies (dense), 7 were proved to be malignant by histopathological evaluation (false –ve). The sensitivity, specificity, positive and negative predictive values of MRI for occult breast lesions in high risk patients included in the study, were found to be 100%, 93%, 86%, and 100% respectively. Overall accuracy of MRI breast was 95%. Among the 38 cases diagnosed by MRI as malignant, there was no false +ve, while among the 22 cases diagnosed by MRI to be benign lesions, 7 cases were proved to be malignant by histopathological evaluation (false –ve). Therefore breast MRI had higher sensitivity than specificity but general speaking it is considered highly valid with high specificity also. Due to the limited number of cases in this study, there was a trend in relation of obesity (BMI) to breast cancer, malignancy rate 55.3% in obese women and 44.7% in non-obese women.
CONCLUSION: From our study, we conclude that MR imaging of the breast in obese women , is a rapidly evolving modality of excellent sensitivity in detection of breast cancer. The basic drawback of this modality was its low specificity for breast malignancy. However, multiple studies including this study have shown that with the improvement in equipment and technique there is gradual increase in specificity.
The Egyptian Journal of Hospital Medicine
Pan Arab League of Continuous Medical Education
1687-2002
52
v.
1
no.
2013
708
724
https://ejhm.journals.ekb.eg/article_15939_ad1f284f1734249b885487e10e09d343.pdf
dx.doi.org/10.12816/0000609
Antidiabetic and Antihyperlipidemic Effect of Balanites aegyptiaca Seeds (Aqueous Extract) on Diabetic Rats
Eman G. E.
Helal
Department of Zoology–Faculty of Science Al-Azhar University, Department of Medical Science
author
Samia M.
Abd El-Wahab
Department of Zoology–Faculty of Science Al-Azhar University, Department of Medical Science
author
Hesham
El Refaey
department of pharmacology-Faculty of pharmacy- Al-Azhar University, Department of Medical Science
author
Anwaar Alkamel
Mohammad
Faculty of Dentistry - Sinai University
author
text
article
2013
eng
Objectives: Type II diabetes mellitus is increasing health problems that negatively affect health care systems worldwide. There is a constant urge to develop new therapies with better effects, lower side effects at lower prices to treat this disease. Therefore, the present study carried out to investigate whether Balanites aegyptiaca (seeds) could treat the hyperglycemic, dislipidemic, liver, and kidney toxicity and the pancreatic damage in diabetic rats.
Material and method: fifteen adult male albino rats were divided into two groups; group 1: control group, group 2: alloxan induced diabetic rats that divided into two subgroups; subgroup1: diabetic untreated rats, subgroup2: diabetic treated with aqueous extract of B. aegyptiaca (seeds). After thirty days of treatment, all rats were sacrificed. Blood sample were collected to estimate some hematological and biochemical parameters. Liver samples were collected to determine their glycogen content and pancreatic samples were obtained and processed for microscopic and quantitative evaluation of α, β & δ-cells number.
Results: diabetic group recorded reduction in body weight's gained, hyperglycemia, hypoinsulinemia, significant increase in some parameters of liver and kidney functions, dislipidemia, changes in proteins level and decreased liver glycogen content. While, treatment with B. aegyptiaca (seeds) was ameliorated most of the toxic effects of alloxan and showed partially improvement in histological changes produced by alloxan.
Conclusion: The aqueous extract of B. aegyptiaca (seeds) has hypoglycemic, hypolipidemic effects, increasing insulin level, and decreasing insulin resistance. Moreover, ameliorate the most complication associated with diabetes mellitus.
The Egyptian Journal of Hospital Medicine
Pan Arab League of Continuous Medical Education
1687-2002
52
v.
1
no.
2013
725
739
https://ejhm.journals.ekb.eg/article_15940_147bd50faa007162f1f8de931c0f2885.pdf
dx.doi.org/10.12816/0000610
Effects of Anti-Tuberculous Drugs on Liver Function Profile in Libyan Patients with Tuberculosis
Mokhtar
Hadida
Department of Family & Community Medicine, Faculty of Medicine, Tripoli University, 13662 Tripoli – Libya
author
Amal
Abo-Smhadana
Division of Zoology, Department of Biological Sciences, School of Basic Sciences, Academy of Graduate Studies, 72331, Janzour, Libya
author
Marwan
Draid
Department of Pharmacology, Toxicology & Forensic Medicine, Faculty of Veterinary Medicine, Tripoli University, 13662 Tripoli, Libya.
author
text
article
2013
eng
The present prospective study was designed to conduct a local survey on patients under anti-tuberculosis therapy hospitalized in Abo-Seta hospital, Tripoli, Libya from the safety point of view. The study was carried out on 75 inpatients. The effects of the used drugs on some hematological parameters and liver function biomarkers were monitored for six-month period of treatment. Our survey showed that tuberculosis affects people with low and medium levels of education and withno job. The frequency of adverse effects related to treatment with Abo-Seta hospital regimen were decreases in WBCs count (-38.7%), RBCs count (-32.1%), platelets count (-33%) and hemoglobin concentration (-35.5%). However, in most of the cases, it was not necessary to modify the treatment regimen because of such side effects. Some parameters showed spontaneous recovery as RBCs count (+22.1%) and hemoglobin level (+20.1%). Combined therapy of ethambutol, isoniazid, pyrazinamide, and rifampicin has been used in Abo-Seta hospital, as a regimen for tuberculosis infection, may be associated with a high risk of hepatic toxicity during first month of treatment. However, during the remaining five months there was a good recovery of liver enzymes profile. Upon the data obtained from the present study, it could be concluded that TB patient after 6 month of treatment didn't develop multi-drug resistant tuberculosis (MDR-TB)
The Egyptian Journal of Hospital Medicine
Pan Arab League of Continuous Medical Education
1687-2002
52
v.
1
no.
2013
740
751
https://ejhm.journals.ekb.eg/article_15941_052ae18f44fef1447d1f5e1c9facd802.pdf
dx.doi.org/10.12816/0000611